5BXU

Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n4m5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity
A	0016055	biological_process	Wnt signaling pathway
A	0032212	biological_process	positive regulation of telomere maintenance via telomerase
A	0051225	biological_process	spindle assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue CL A 701

Chain	Residue
A	ARG538
A	VAL539
A	SER540
A	VAL541
A	HOH935

---

site_id	AC2
Number of Residues	8
Details	binding site for residue 4XQ B 101

Chain	Residue
A	HOH872
B	ALA4
B	ALA8
B	GMA9
A	VAL514
A	LEU612
A	PRO618
A	LEU643

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Repeat: {"description":"ANK 10"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	32
Details	Repeat: {"description":"ANK 11"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	32
Details	Repeat: {"description":"ANK 12"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	8
Details	Region: {"description":"HIF1AN-binding","evidences":[{"source":"PubMed","id":"21251231","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"(3S)-3-hydroxyasparagine; by HIF1AN; partial","evidences":[{"source":"PubMed","id":"18936059","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"(3S)-3-hydroxyhistidine; by HIF1AN; partial","evidences":[{"source":"PubMed","id":"21251231","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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