5BXQ

Structure of the NTF2:RanGDP complex

Replaces:  1A2K

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005637	cellular_component	nuclear inner membrane
A	0005640	cellular_component	nuclear outer membrane
A	0005643	cellular_component	nuclear pore
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006606	biological_process	protein import into nucleus
A	0006611	biological_process	protein export from nucleus
A	0006913	biological_process	nucleocytoplasmic transport
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0017056	molecular_function	structural constituent of nuclear pore
A	0031267	molecular_function	small GTPase binding
A	0031965	cellular_component	nuclear membrane
A	0042307	biological_process	positive regulation of protein import into nucleus
A	0042802	molecular_function	identical protein binding
A	0044613	cellular_component	nuclear pore central transport channel
A	0051028	biological_process	mRNA transport
A	0061608	molecular_function	nuclear import signal receptor activity
A	0090204	biological_process	protein localization to nuclear pore
A	1904046	biological_process	negative regulation of vascular endothelial growth factor production
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005637	cellular_component	nuclear inner membrane
B	0005640	cellular_component	nuclear outer membrane
B	0005643	cellular_component	nuclear pore
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006606	biological_process	protein import into nucleus
B	0006611	biological_process	protein export from nucleus
B	0006913	biological_process	nucleocytoplasmic transport
B	0015031	biological_process	protein transport
B	0016020	cellular_component	membrane
B	0017056	molecular_function	structural constituent of nuclear pore
B	0031267	molecular_function	small GTPase binding
B	0031965	cellular_component	nuclear membrane
B	0042307	biological_process	positive regulation of protein import into nucleus
B	0042802	molecular_function	identical protein binding
B	0044613	cellular_component	nuclear pore central transport channel
B	0051028	biological_process	mRNA transport
B	0061608	molecular_function	nuclear import signal receptor activity
B	0090204	biological_process	protein localization to nuclear pore
B	1904046	biological_process	negative regulation of vascular endothelial growth factor production
C	0000054	biological_process	ribosomal subunit export from nucleus
C	0000070	biological_process	mitotic sister chromatid segregation
C	0000287	molecular_function	magnesium ion binding
C	0003924	molecular_function	GTPase activity
C	0005049	molecular_function	nuclear export signal receptor activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005635	cellular_component	nuclear envelope
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006606	biological_process	protein import into nucleus
C	0006611	biological_process	protein export from nucleus
C	0006913	biological_process	nucleocytoplasmic transport
C	0015031	biological_process	protein transport
C	0016442	cellular_component	RISC complex
C	0016787	molecular_function	hydrolase activity
C	0032991	cellular_component	protein-containing complex
C	0035281	biological_process	pre-miRNA export from nucleus
C	0042470	cellular_component	melanosome
C	0046039	biological_process	GTP metabolic process
C	0046827	biological_process	positive regulation of protein export from nucleus
C	0046872	molecular_function	metal ion binding
C	0051301	biological_process	cell division
C	0061015	biological_process	snRNA import into nucleus
C	0070883	molecular_function	pre-miRNA binding
C	1905172	molecular_function	RISC complex binding
D	0000054	biological_process	ribosomal subunit export from nucleus
D	0000070	biological_process	mitotic sister chromatid segregation
D	0000287	molecular_function	magnesium ion binding
D	0003924	molecular_function	GTPase activity
D	0005049	molecular_function	nuclear export signal receptor activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005634	cellular_component	nucleus
D	0005635	cellular_component	nuclear envelope
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006606	biological_process	protein import into nucleus
D	0006611	biological_process	protein export from nucleus
D	0006913	biological_process	nucleocytoplasmic transport
D	0015031	biological_process	protein transport
D	0016442	cellular_component	RISC complex
D	0016787	molecular_function	hydrolase activity
D	0032991	cellular_component	protein-containing complex
D	0035281	biological_process	pre-miRNA export from nucleus
D	0042470	cellular_component	melanosome
D	0046039	biological_process	GTP metabolic process
D	0046827	biological_process	positive regulation of protein export from nucleus
D	0046872	molecular_function	metal ion binding
D	0051301	biological_process	cell division
D	0061015	biological_process	snRNA import into nucleus
D	0070883	molecular_function	pre-miRNA binding
D	1905172	molecular_function	RISC complex binding
E	0000054	biological_process	ribosomal subunit export from nucleus
E	0000070	biological_process	mitotic sister chromatid segregation
E	0000287	molecular_function	magnesium ion binding
E	0003924	molecular_function	GTPase activity
E	0005049	molecular_function	nuclear export signal receptor activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005635	cellular_component	nuclear envelope
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006606	biological_process	protein import into nucleus
E	0006611	biological_process	protein export from nucleus
E	0006913	biological_process	nucleocytoplasmic transport
E	0015031	biological_process	protein transport
E	0016442	cellular_component	RISC complex
E	0016787	molecular_function	hydrolase activity
E	0032991	cellular_component	protein-containing complex
E	0035281	biological_process	pre-miRNA export from nucleus
E	0042470	cellular_component	melanosome
E	0046039	biological_process	GTP metabolic process
E	0046827	biological_process	positive regulation of protein export from nucleus
E	0046872	molecular_function	metal ion binding
E	0051301	biological_process	cell division
E	0061015	biological_process	snRNA import into nucleus
E	0070883	molecular_function	pre-miRNA binding
E	1905172	molecular_function	RISC complex binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue GDP C 301

Chain	Residue
C	GLY20
C	ASP125
C	ILE126
C	SER150
C	ALA151
C	LYS152
C	MG302
C	HOH418
C	HOH428
C	HOH433
C	HOH435
C	THR21
C	GLY22
C	LYS23
C	THR24
C	THR25
C	GLU70
C	ASN122
C	LYS123

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG C 302

Chain	Residue
C	THR24
C	GDP301
C	HOH418
C	HOH424
C	HOH428
C	HOH435

---

site_id	AC3
Number of Residues	18
Details	binding site for residue GDP D 301

Chain	Residue
D	GLY19
D	GLY20
D	THR21
D	GLY22
D	LYS23
D	THR24
D	THR25
D	ASN122
D	LYS123
D	ASP125
D	ILE126
D	SER150
D	ALA151
D	LYS152
D	MG302
D	HOH412
D	HOH416
D	HOH434

---

site_id	AC4
Number of Residues	6
Details	binding site for residue MG D 302

Chain	Residue
D	THR24
D	GDP301
D	HOH412
D	HOH425
D	HOH427
D	HOH434

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MG E 301

Chain	Residue
E	THR24
E	GDP303
E	HOH401
E	HOH412
E	HOH421
E	HOH427

---

site_id	AC6
Number of Residues	11
Details	binding site for residue SO4 E 302

Chain	Residue
D	THR32
D	PRO180
D	ALA181
D	HOH452
E	THR32
E	PRO180
E	ALA181
E	HOH417
E	HOH420
E	HOH449
E	HOH450

---

site_id	AC7
Number of Residues	18
Details	binding site for residue GDP E 303

Chain	Residue
E	GLY20
E	THR21
E	GLY22
E	LYS23
E	THR24
E	THR25
E	GLU70
E	ASN122
E	LYS123
E	ASP125
E	ILE126
E	ALA151
E	LYS152
E	MG301
E	HOH401
E	HOH415
E	HOH421
E	HOH457

---

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LGAIyiDaSCLTWEG

Chain	Residue	Details
A	LEU29-GLY43

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:15602554, ECO:0000269|PubMed:15864302, ECO:0000269|PubMed:19965479, ECO:0000269|PubMed:9533885, ECO:0000269|PubMed:9878368, ECO:0007744|PDB:1BYU, ECO:0007744|PDB:1WA5, ECO:0007744|PDB:2BKU, ECO:0007744|PDB:3A6P, ECO:0007744|PDB:3RAN, ECO:0007744|PDB:3W3Z, ECO:0007744|PDB:5BXQ

Chain	Residue	Details
C	ASP18
C	ASN122
C	SER150
D	ASP18
D	ASN122
D	SER150
E	ASP18
E	ASN122
E	SER150

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:15602554, ECO:0000269|PubMed:15864302, ECO:0000269|PubMed:19965479, ECO:0007744|PDB:1WA5, ECO:0007744|PDB:2BKU, ECO:0007744|PDB:3A6P, ECO:0007744|PDB:3W3Z

Chain	Residue	Details
C	GLU36
D	GLU36
E	GLU36

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:15602554, ECO:0000269|PubMed:15864302, ECO:0000269|PubMed:19965479, ECO:0007744|PDB:1WA5, ECO:0007744|PDB:2BKU, ECO:0007744|PDB:3W3Z

Chain	Residue	Details
C	GLY68
D	GLY68
E	GLY68

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	SITE: Essential for GTP hydrolysis => ECO:0000250|UniProtKB:P62826

Chain	Residue	Details
C	GLN69
D	GLN69
E	GLN69

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P62826

Chain	Residue	Details
C	ALA2
D	ALA2
E	ALA2

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62826

Chain	Residue	Details
C	THR24
D	THR24
E	THR24

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P62826

Chain	Residue	Details
C	LYS37
E	LYS60
E	LYS99
E	LYS134
C	LYS60
C	LYS99
C	LYS134
D	LYS37
D	LYS60
D	LYS99
D	LYS134
E	LYS37

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P62826

Chain	Residue	Details
C	LYS71
D	LYS71
E	LYS71

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62827

Chain	Residue	Details
C	LYS159
D	LYS159
E	LYS159

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62826

Chain	Residue	Details
C	LYS71
D	LYS71
E	LYS71

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:P62826

Chain	Residue	Details
C	LYS152
D	LYS152
E	LYS152

---