5BWO

Crystal Structure of Human SIRT3 in Complex with a Palmitoyl H3K9 Peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0017136	molecular_function	NAD-dependent histone deacetylase activity
A	0051287	molecular_function	NAD binding
A	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue PLM B 101

Chain	Residue
A	PHE157
A	PRO176
A	ILE179
A	PHE180
A	HIS248
B	LYS5
B	HOH206

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 401

Chain	Residue
A	CYS280
A	CYS283
A	CYS256
A	CYS259

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000250|UniProtKB:P68431

Chain	Residue	Details
B	GLN1

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000250|UniProtKB:P68431

Chain	Residue	Details
B	THR2
B	THR7
A	GLY319
A	ASN344

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433

Chain	Residue	Details
B	ARG4
A	CYS259
A	CYS280
A	CYS283

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P68432

Chain	Residue	Details
B	LYS5

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000250|UniProtKB:P68432

Chain	Residue	Details
B	SER6

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