5BV6

PKG II's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with cGMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004692	molecular_function	cGMP-dependent protein kinase activity
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue 35G A 501

Chain	Residue
A	GLN335
A	ALA368
A	ILE370
A	ASP412
A	ARG415
A	HOH608
A	HOH629
A	HOH636
A	LYS347
A	PHE355
A	GLY356
A	GLU357
A	LYS358
A	ALA359
A	ARG366
A	SER367

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site_id	AC2
Number of Residues	7
Details	binding site for residue CA A 502

Chain	Residue
A	ASP364
A	HOH610
A	HOH617
A	HOH635
A	HOH691
A	HOH695
A	HOH705

---

site_id	AC3
Number of Residues	2
Details	binding site for residue ACT A 503

Chain	Residue
A	ASP300
A	LYS418

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site_id	AC4
Number of Residues	1
Details	binding site for residue CA A 504

Chain	Residue
A	HOH702

---

site_id	AC5
Number of Residues	3
Details	binding site for residue NA A 505

Chain	Residue
A	GLU353
A	TYR354
A	TYR404

---

Functional Information from PROSITE/UniProt

site_id	PS00888
Number of Residues	17
Details	CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrEGEeGStFFILakG

Chain	Residue	Details
A	ILE313-GLY329

---

site_id	PS00889
Number of Residues	18
Details	CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEkALisddv......RSAnIiA

Chain	Residue	Details
A	PHE355-ALA372

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	130
Details	Region: {"description":"cGMP-binding, high affinity; cAMP-binding, low affinity","evidences":[{"source":"PubMed","id":"26769964","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26769964","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BV6","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26769964","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BV6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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