5BTI

Crystal structure of a topoisomerase II complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006259	biological_process	DNA metabolic process
A	0006265	biological_process	DNA topological change
B	0003677	molecular_function	DNA binding
B	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
B	0005524	molecular_function	ATP binding
B	0006265	biological_process	DNA topological change
C	0003677	molecular_function	DNA binding
C	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
C	0005524	molecular_function	ATP binding
C	0006259	biological_process	DNA metabolic process
C	0006265	biological_process	DNA topological change
D	0003677	molecular_function	DNA binding
D	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
D	0005524	molecular_function	ATP binding
D	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MG B 701

Chain	Residue
B	ASP532
B	ASP534
B	HOH804
B	HOH808
B	HOH809
G	HOH102

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG C 601

Chain	Residue
F	HOH204
F	HOH210
C	HOH723
F	LFX101
F	HOH202

---

site_id	AC3
Number of Residues	7
Details	binding site for residue MG D 701

Chain	Residue
D	GLU459
D	ASP532
D	ASP534
D	HOH805
D	HOH807
D	HOH809
D	HOH829

---

site_id	AC4
Number of Residues	15
Details	binding site for residue LFX E 101

Chain	Residue
A	SER90
A	HOH626
B	THR500
E	DT10
E	DG11
E	MG102
E	HOH201
E	HOH204
E	HOH205
F	DC14
F	DA15
G	DT10
G	DA11
H	DT14
H	DA15

---

site_id	AC5
Number of Residues	7
Details	binding site for residue MG E 102

Chain	Residue
A	SER90
A	HOH626
E	DT10
E	LFX101
E	HOH201
E	HOH204
E	HOH210

---

site_id	AC6
Number of Residues	16
Details	binding site for residue LFX F 101

Chain	Residue
C	SER90
C	MG601
C	HOH723
D	ARG482
E	DT14
E	DA15
F	DT10
F	DA11
F	HOH202
F	HOH204
F	HOH208
F	HOH210
G	DC14
G	DA15
H	DT10
H	DG11

---

Functional Information from PROSITE/UniProt

site_id	PS00177
Number of Residues	9
Details	TOPOISOMERASE_II DNA topoisomerase II signature. VVEGDSAGG

Chain	Residue	Details
B	VAL457-GLY465

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01897","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	228
Details	Domain: {"description":"Toprim","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Interaction with DNA","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---