5BR4
E. coli lactaldehyde reductase (FucO) M185C mutant
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
A | 0005829 | cellular_component | cytosol |
A | 0006004 | biological_process | fucose metabolic process |
A | 0008198 | molecular_function | ferrous iron binding |
A | 0008912 | molecular_function | lactaldehyde reductase activity |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0019301 | biological_process | rhamnose catabolic process |
A | 0019317 | biological_process | fucose catabolic process |
A | 0042355 | biological_process | L-fucose catabolic process |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0042846 | biological_process | glycol catabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0051143 | biological_process | propanediol metabolic process |
A | 0052660 | molecular_function | R-lactaldehyde reductase activity |
A | 0052661 | molecular_function | S-lactaldehyde reductase activity |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
B | 0005829 | cellular_component | cytosol |
B | 0006004 | biological_process | fucose metabolic process |
B | 0008198 | molecular_function | ferrous iron binding |
B | 0008912 | molecular_function | lactaldehyde reductase activity |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0019301 | biological_process | rhamnose catabolic process |
B | 0019317 | biological_process | fucose catabolic process |
B | 0042355 | biological_process | L-fucose catabolic process |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0042846 | biological_process | glycol catabolic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0051143 | biological_process | propanediol metabolic process |
B | 0052660 | molecular_function | R-lactaldehyde reductase activity |
B | 0052661 | molecular_function | S-lactaldehyde reductase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 401 |
Chain | Residue |
A | ASP196 |
A | HIS200 |
A | HIS263 |
A | HIS277 |
site_id | AC2 |
Number of Residues | 36 |
Details | binding site for residue NAD A 402 |
Chain | Residue |
A | GLY97 |
A | GLY98 |
A | SER99 |
A | PRO100 |
A | ASP102 |
A | THR140 |
A | THR141 |
A | THR144 |
A | ALA146 |
A | THR149 |
A | ASN151 |
A | VAL153 |
A | LYS162 |
A | MET181 |
A | GLY184 |
A | CYS185 |
A | LEU189 |
A | HIS277 |
A | GOL403 |
A | CL405 |
A | HOH523 |
A | HOH559 |
A | HOH569 |
A | HOH623 |
A | HOH672 |
A | HOH703 |
A | HOH734 |
A | HOH770 |
A | HOH799 |
A | HOH824 |
A | HOH837 |
A | ASP39 |
A | THR41 |
A | LEU42 |
A | PRO70 |
A | ASN71 |
site_id | AC3 |
Number of Residues | 10 |
Details | binding site for residue GOL A 403 |
Chain | Residue |
A | ASN151 |
A | VAL153 |
A | PHE254 |
A | LEU259 |
A | HIS267 |
A | CYS362 |
A | NAD402 |
A | CL405 |
A | HOH618 |
A | HOH719 |
site_id | AC4 |
Number of Residues | 7 |
Details | binding site for residue GOL A 404 |
Chain | Residue |
A | HIS339 |
A | ASP342 |
A | LEU384 |
A | HOH540 |
A | HOH567 |
B | ARG332 |
B | ASP333 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue CL A 405 |
Chain | Residue |
A | VAL153 |
A | HIS267 |
A | HIS277 |
A | NAD402 |
A | GOL403 |
site_id | AC6 |
Number of Residues | 3 |
Details | binding site for residue CL A 406 |
Chain | Residue |
A | LYS162 |
A | HIS267 |
A | HIS277 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue ZN B 401 |
Chain | Residue |
B | ASP196 |
B | HIS200 |
B | HIS263 |
B | HIS277 |
site_id | AC8 |
Number of Residues | 36 |
Details | binding site for residue NAD B 402 |
Chain | Residue |
B | HOH699 |
B | HOH715 |
B | HOH720 |
B | HOH761 |
B | HOH779 |
B | HOH786 |
B | ASP39 |
B | THR41 |
B | LEU42 |
B | PRO70 |
B | ASN71 |
B | GLY97 |
B | GLY98 |
B | SER99 |
B | PRO100 |
B | ASP102 |
B | THR140 |
B | THR141 |
B | THR144 |
B | ALA146 |
B | THR149 |
B | ASN151 |
B | VAL153 |
B | LYS162 |
B | MET181 |
B | GLY184 |
B | CYS185 |
B | LEU189 |
B | HIS277 |
B | GOL403 |
B | CL405 |
B | HOH520 |
B | HOH561 |
B | HOH578 |
B | HOH634 |
B | HOH649 |
site_id | AC9 |
Number of Residues | 10 |
Details | binding site for residue GOL B 403 |
Chain | Residue |
B | ASN151 |
B | VAL153 |
B | PHE254 |
B | LEU259 |
B | HIS267 |
B | CYS362 |
B | NAD402 |
B | CL405 |
B | HOH574 |
B | HOH741 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue CL B 404 |
Chain | Residue |
B | LYS162 |
B | ALA266 |
B | HIS267 |
B | HIS277 |
B | HOH515 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue CL B 405 |
Chain | Residue |
B | VAL153 |
B | HIS267 |
B | HIS277 |
B | NAD402 |
B | GOL403 |
Functional Information from PROSITE/UniProt
site_id | PS00060 |
Number of Residues | 21 |
Details | ADH_IRON_2 Iron-containing alcohol dehydrogenases signature 2. GlVHgmAHpLGAfynTpHGvA |
Chain | Residue | Details |
A | GLY260-ALA280 |
site_id | PS00913 |
Number of Residues | 29 |
Details | ADH_IRON_1 Iron-containing alcohol dehydrogenases signature 1. AFiDadmmdgcPpalkAaTgvDALthaiE |
Chain | Residue | Details |
A | ALA175-GLU203 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0007744|PDB:2BI4, ECO:0007744|PDB:2BL4, ECO:0007744|PDB:5BR4 |
Chain | Residue | Details |
A | ASP39 | |
B | LYS162 | |
B | MET181 | |
B | HIS277 | |
A | GLY98 | |
A | THR140 | |
A | LYS162 | |
A | MET181 | |
A | HIS277 | |
B | ASP39 | |
B | GLY98 | |
B | THR140 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0007744|PDB:2BI4, ECO:0007744|PDB:2BL4 |
Chain | Residue | Details |
A | ASN71 | |
B | ASN71 | |
A | ASP342 | |
B | ASP342 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | ASN151 | |
B | ASN151 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0007744|PDB:1RRM, ECO:0007744|PDB:2BI4, ECO:0007744|PDB:2BL4, ECO:0007744|PDB:5BR4 |
Chain | Residue | Details |
A | ASP196 | |
A | HIS200 | |
A | HIS263 | |
B | ASP196 | |
B | HIS200 | |
B | HIS263 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0007744|PDB:2BL4, ECO:0007744|PDB:5BR4 |
Chain | Residue | Details |
A | THR149 | |
B | THR149 |