Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5BOZ

Ricin A chain bound to camelid nanobody (VHH9)(E1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0017148	biological_process	negative regulation of translation
A	0030598	molecular_function	rRNA N-glycosylase activity
B	0017148	biological_process	negative regulation of translation
B	0030598	molecular_function	rRNA N-glycosylase activity
C	0017148	biological_process	negative regulation of translation
C	0030598	molecular_function	rRNA N-glycosylase activity
D	0017148	biological_process	negative regulation of translation
D	0030598	molecular_function	rRNA N-glycosylase activity
E	0017148	biological_process	negative regulation of translation
E	0030598	molecular_function	rRNA N-glycosylase activity
F	0017148	biological_process	negative regulation of translation
F	0030598	molecular_function	rRNA N-glycosylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 A 301

Chain	Residue
A	PHE119
A	GLY120
A	ASN122
A	ARG125

site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 302

Chain	Residue
A	ARG125
A	GLN128
H	LYS43

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 G 201

Chain	Residue
A	GLY87
A	GLU61
A	ARG85

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 B 301

Chain	Residue
B	PHE119
B	GLY120
B	ASN122
B	ARG125

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 B 302

Chain	Residue
B	GLY142
B	ARG197
H	SER30

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 B 303

Chain	Residue
B	GLU61
B	ARG85
B	GLY87
H	GLY8

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 B 304

Chain	Residue
B	ARG189
B	THR190
B	ARG193

site_id	AC8
Number of Residues	1
Details	binding site for residue SO4 B 305

Chain	Residue
B	ARG125

site_id	AC9
Number of Residues	5
Details	binding site for residue SO4 C 301

Chain	Residue
C	PHE119
C	GLY120
C	ASN122
C	ARG125
C	HOH403

site_id	AD1
Number of Residues	1
Details	binding site for residue SO4 C 302

Chain	Residue
C	ARG125

site_id	AD2
Number of Residues	2
Details	binding site for residue SO4 C 303

Chain	Residue
C	TYR115
D	TYR115

site_id	AD3
Number of Residues	3
Details	binding site for residue SO4 I 201

Chain	Residue
D	ARG85
I	SER7
I	GLY8

site_id	AD4
Number of Residues	1
Details	binding site for residue SO4 D 301

Chain	Residue
D	ARG125

site_id	AD5
Number of Residues	1
Details	binding site for residue CL D 302

Chain	Residue
D	ARG125

site_id	AD6
Number of Residues	5
Details	binding site for residue SO4 J 201

Chain	Residue
C	ARG85
C	GLY87
J	SER7
J	GLY8
J	THR120

site_id	AD7
Number of Residues	4
Details	binding site for residue SO4 E 301

Chain	Residue
E	ARG85
E	GLY87
K	SER7
K	GLY8

site_id	AD8
Number of Residues	3
Details	binding site for residue SO4 E 302

Chain	Residue
E	GLY142
E	ARG197
K	SER30

site_id	AD9
Number of Residues	3
Details	binding site for residue SO4 E 303

Chain	Residue
E	ARG125
E	GLN128
K	LYS43

site_id	AE1
Number of Residues	2
Details	binding site for residue CL E 304

Chain	Residue
E	GLY120
E	ARG125

site_id	AE2
Number of Residues	2
Details	binding site for residue CL K 201

Chain	Residue
K	THR58
K	TYR60

site_id	AE3
Number of Residues	4
Details	binding site for residue SO4 F 301

Chain	Residue
F	PHE119
F	GLY120
F	ASN122
F	ARG125

site_id	AE4
Number of Residues	2
Details	binding site for residue SO4 F 302

Chain	Residue
F	ARG125
L	LYS43

site_id	AE5
Number of Residues	4
Details	binding site for residue SO4 L 201

Chain	Residue
F	ARG85
F	GLY87
L	SER7
L	GLY8

Functional Information from PROSITE/UniProt

site_id	PS00275
Number of Residues	17
Details	SHIGA_RICIN Shiga/ricin ribosomal inactivating toxins active site signature. IqMIsEAARFQyIEgeM

Chain	Residue	Details
A	ILE172-MET188

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	ACT_SITE: ACT_SITE => ECO:0000250\|UniProtKB:P84531

Chain	Residue	Details
A	TYR80
C	TYR123
C	GLU177
C	ARG180
D	TYR80
D	TYR123
D	GLU177
D	ARG180
E	TYR80
E	TYR123
E	GLU177
A	TYR123
E	ARG180
F	TYR80
F	TYR123
F	GLU177
F	ARG180
A	GLU177
A	ARG180
B	TYR80
B	TYR123
B	GLU177
B	ARG180
C	TYR80

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ILE8
B	ILE8
C	ILE8
D	ILE8
E	ILE8
F	ILE8

site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING:

Chain	Residue	Details
A	GLY15
C	GLY50
C	ASN141
C	ASN195
D	GLY15
D	GLY50
D	ASN141
D	ASN195
E	GLY15
E	GLY50
E	ASN141
A	GLY50
E	ASN195
F	GLY15
F	GLY50
F	ASN141
F	ASN195
A	ASN141
A	ASN195
B	GLY15
B	GLY50
B	ASN141
B	ASN195
C	GLY15

site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:8780513, ECO:0007744\|PDB:1OBT

Chain	Residue	Details
A	TYR80
E	GLY121
F	TYR80
F	GLY121
A	GLY121
B	TYR80
B	GLY121
C	TYR80
C	GLY121
D	TYR80
D	GLY121
E	TYR80

site_id	SWS_FT_FI5
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:1368517

Chain	Residue	Details
A	ASN10
B	ASN10
C	ASN10
D	ASN10
E	ASN10
F	ASN10

site_id	SWS_FT_FI6
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269\|PubMed:1368517

Chain	Residue	Details
A	ASN236
B	ASN236
C	ASN236
D	ASN236
E	ASN236
F	ASN236

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)