5BO3
Bianthranilate-like inhibitor with 5 atom "line" and phosphonate "hook" fishing for hydrogen bond donors in Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000162 | biological_process | tryptophan biosynthetic process |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0004048 | molecular_function | anthranilate phosphoribosyltransferase activity |
A | 0005829 | cellular_component | cytosol |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0016763 | molecular_function | pentosyltransferase activity |
A | 0046872 | molecular_function | metal ion binding |
B | 0000162 | biological_process | tryptophan biosynthetic process |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0004048 | molecular_function | anthranilate phosphoribosyltransferase activity |
B | 0005829 | cellular_component | cytosol |
B | 0016757 | molecular_function | glycosyltransferase activity |
B | 0016763 | molecular_function | pentosyltransferase activity |
B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 22 |
Details | binding site for residue 7P2 A 400 |
Chain | Residue |
A | MET86 |
A | ARG187 |
A | ALA190 |
A | ARG193 |
A | ARG194 |
A | GLY206 |
A | HOH504 |
A | HOH510 |
A | HOH516 |
A | HOH522 |
A | HOH571 |
A | HIS91 |
A | HOH591 |
A | HOH617 |
A | HOH640 |
A | ASN138 |
A | ALA179 |
A | PRO180 |
A | ARG181 |
A | HIS183 |
A | PRO184 |
A | TYR186 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue IMD A 401 |
Chain | Residue |
A | ASP159 |
A | ASP159 |
A | ARG181 |
A | ARG181 |
A | HOH531 |
A | HOH531 |
site_id | AC3 |
Number of Residues | 13 |
Details | binding site for residue 7P2 B 400 |
Chain | Residue |
A | THR256 |
A | THR257 |
A | ARG283 |
B | ASN138 |
B | ALA179 |
B | PRO180 |
B | HIS183 |
B | PRO184 |
B | TYR186 |
B | ARG187 |
B | ALA190 |
B | ARG193 |
B | ARG194 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue IMD B 401 |
Chain | Residue |
B | TRP47 |
B | ASP50 |
B | GLU342 |
B | ARG346 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 22 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00211 |
Chain | Residue | Details |
A | THR115 | |
A | ASN117 | |
A | SER119 | |
A | LYS135 | |
A | ASN138 | |
A | GLY147 | |
A | ARG193 | |
A | ASP251 | |
A | GLU252 | |
B | GLY107 | |
B | GLY110 | |
B | THR115 | |
B | ASN117 | |
B | SER119 | |
B | LYS135 | |
B | ASN138 | |
B | GLY147 | |
B | ARG193 | |
B | ASP251 | |
B | GLU252 | |
A | GLY107 | |
A | GLY110 |