Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5BMX

Crystal structure of T75N mutant of Triosephosphate isomerase from Plasmodium falciparum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004807	molecular_function	triose-phosphate isomerase activity
A	0005829	cellular_component	cytosol
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0016853	molecular_function	isomerase activity
A	0019563	biological_process	glycerol catabolic process
A	0042802	molecular_function	identical protein binding
A	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
B	0004807	molecular_function	triose-phosphate isomerase activity
B	0005829	cellular_component	cytosol
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0016853	molecular_function	isomerase activity
B	0019563	biological_process	glycerol catabolic process
B	0042802	molecular_function	identical protein binding
B	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
C	0004807	molecular_function	triose-phosphate isomerase activity
C	0005829	cellular_component	cytosol
C	0006094	biological_process	gluconeogenesis
C	0006096	biological_process	glycolytic process
C	0016853	molecular_function	isomerase activity
C	0019563	biological_process	glycerol catabolic process
C	0042802	molecular_function	identical protein binding
C	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
D	0004807	molecular_function	triose-phosphate isomerase activity
D	0005829	cellular_component	cytosol
D	0006094	biological_process	gluconeogenesis
D	0006096	biological_process	glycolytic process
D	0016853	molecular_function	isomerase activity
D	0019563	biological_process	glycerol catabolic process
D	0042802	molecular_function	identical protein binding
D	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue EDO A 301

Chain	Residue
A	ASN10
A	LYS12
A	HIS95
A	LEU230
A	HOH413
A	HOH444

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO A 302

Chain	Residue
A	LYS36
A	ARG3
A	LYS4
A	TYR5

site_id	AC3
Number of Residues	5
Details	binding site for residue NA A 303

Chain	Residue
A	ILE221
A	GLN223
A	ILE226
A	HOH430
A	HOH474

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 A 304

Chain	Residue
A	SER211
A	GLY232
A	ASN233
A	HOH415
A	HOH426
A	HOH547

site_id	AC5
Number of Residues	7
Details	binding site for residue EDO B 301

Chain	Residue
B	ASN65
B	HOH420
B	HOH479
B	HOH526
B	HOH557
B	HOH565
C	GLY76

site_id	AC6
Number of Residues	6
Details	binding site for residue EDO B 302

Chain	Residue
B	GLY76
B	HOH447
B	HOH460
B	HOH512
C	ASN65
C	HOH487

site_id	AC7
Number of Residues	5
Details	binding site for residue EDO B 303

Chain	Residue
B	ASN10
B	LYS12
B	HIS95
B	LEU230
B	HOH468

site_id	AC8
Number of Residues	6
Details	binding site for residue NA B 304

Chain	Residue
B	TYR5
B	ILE221
B	GLN223
B	ILE226
B	HOH506
B	HOH555

site_id	AC9
Number of Residues	7
Details	binding site for residue SO4 B 305

Chain	Residue
B	SER211
B	GLY232
B	ASN233
B	HOH402
B	HOH404
B	HOH422
B	HOH554

site_id	AD1
Number of Residues	7
Details	binding site for residue EDO C 301

Chain	Residue
C	ASN10
C	LYS12
C	HIS95
C	LEU230
C	SO4303
C	HOH411
C	HOH438

site_id	AD2
Number of Residues	6
Details	binding site for residue NA C 302

Chain	Residue
C	TYR5
C	ILE221
C	GLN223
C	ILE226
C	HOH491
C	HOH524

site_id	AD3
Number of Residues	6
Details	binding site for residue SO4 C 303

Chain	Residue
C	SER211
C	ASN233
C	EDO301
C	HOH402
C	HOH463
C	HOH561

site_id	AD4
Number of Residues	7
Details	binding site for residue EDO D 301

Chain	Residue
A	GLY76
A	HOH482
D	ASN65
D	HOH417
D	HOH457
D	HOH482
D	HOH501

site_id	AD5
Number of Residues	8
Details	binding site for residue EDO D 302

Chain	Residue
D	ASN10
D	LYS12
D	HIS95
D	LEU230
D	GLY232
D	SO4304
D	HOH416
D	HOH438

site_id	AD6
Number of Residues	6
Details	binding site for residue NA D 303

Chain	Residue
D	TYR5
D	ILE221
D	GLN223
D	ILE226
D	HOH500
D	HOH535

site_id	AD7
Number of Residues	7
Details	binding site for residue SO4 D 304

Chain	Residue
D	SER211
D	GLY232
D	ASN233
D	EDO302
D	HOH420
D	HOH433
D	HOH441

Functional Information from PROSITE/UniProt

site_id	PS00171
Number of Residues	11
Details	TIM_1 Triosephosphate isomerase active site. VYEPLWAIGTG

Chain	Residue	Details
A	VAL163-GLY173

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Electrophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10127","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10127","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12454456","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14563846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1M7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O5X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12403619","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15465054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LYX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12403619","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LYX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12454456","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14563846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15465054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1M7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O5X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12403619","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12454456","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14563846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15465054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LZO","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"1LYX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M7P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O5X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)