5BKF
Cyro-EM structure of human Glycine Receptor alpha2-beta heteromer, Glycine bound, desensitized state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016594 | molecular_function | glycine binding |
| A | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016594 | molecular_function | glycine binding |
| B | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0016594 | molecular_function | glycine binding |
| C | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0016594 | molecular_function | glycine binding |
| D | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0006091 | biological_process | generation of precursor metabolites and energy |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0008218 | biological_process | bioluminescence |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS00236 |
| Number of Residues | 15 |
| Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpMdLknFPmDvqtC |
| Chain | Residue | Details |
| A | CYS145-CYS159 | |
| E | CYS161-CYS175 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:34473954, ECO:0007744|PDB:5BKF |
| Chain | Residue | Details |
| E | TYR247-TRP267 | |
| D | LYS1-TYR229 | |
| D | ARG278-LYS288 | |
| D | LYS415-LYS425 | |
| A | ARG278-LYS288 | |
| A | LYS415-LYS425 | |
| B | LYS1-TYR229 | |
| B | ARG278-LYS288 | |
| B | LYS415-LYS425 | |
| C | LYS1-TYR229 | |
| C | ARG278-LYS288 | |
| C | LYS415-LYS425 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:34473954, ECO:0007744|PDB:5BKF |
| Chain | Residue | Details |
| E | ILE268-ALA272 | |
| B | TYR230-ILE251 | |
| C | TYR230-ILE251 | |
| D | TYR230-ILE251 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:34473954, ECO:0007744|PDB:5BKF |
| Chain | Residue | Details |
| E | SER273-THR293 | |
| B | ASN252-ALA256 | |
| C | ASN252-ALA256 | |
| D | ASN252-ALA256 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 11 |
| Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:34473954, ECO:0007744|PDB:5BKF |
| Chain | Residue | Details |
| E | LEU294-LYS305 | |
| B | PRO257-SER277 | |
| C | PRO257-SER277 | |
| D | PRO257-SER277 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:34473954, ECO:0007744|PDB:5BKF |
| Chain | Residue | Details |
| E | ALA306-VAL327 | |
| B | ALA289-ALA309 | |
| C | ALA289-ALA309 | |
| D | ALA289-ALA309 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:34473954, ECO:0007744|PDB:5BKF |
| Chain | Residue | Details |
| E | ILE451-TYR474 | |
| B | ILE394-TYR414 | |
| C | ILE394-TYR414 | |
| D | ILE394-TYR414 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34473954, ECO:0000269|PubMed:37821459, ECO:0007744|PDB:5BKF, ECO:0007744|PDB:8DN5 |
| Chain | Residue | Details |
| E | ARG86 | |
| E | SER152 | |
| C | ARG72 | |
| D | ARG72 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34473954, ECO:0007744|PDB:5BKF |
| Chain | Residue | Details |
| E | THR228 | |
| A | THR211 | |
| B | SER136 | |
| B | THR211 | |
| C | SER136 | |
| C | THR211 | |
| D | SER136 | |
| D | THR211 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | SITE: Important for obstruction of the ion pore in the closed conformation => ECO:0000250|UniProtKB:P23415 |
| Chain | Residue | Details |
| E | LEU285 | |
| D | GLU199 | |
| D | GLU201 | |
| D | HIS222 | |
| A | GLU201 | |
| A | HIS222 | |
| B | GLU199 | |
| B | GLU201 | |
| B | HIS222 | |
| C | GLU199 | |
| C | GLU201 | |
| C | HIS222 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:34473954 |
| Chain | Residue | Details |
| E | ASN32 | |
| E | ASN220 | |
| C | LEU268 | |
| D | LEU268 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: (Z)-2,3-didehydrotyrosine => ECO:0000269|PubMed:8448132 |
| Chain | Residue | Details |
| E | TYR335 | |
| A | ASN76 | |
| B | ASN45 | |
| B | ASN76 | |
| C | ASN45 | |
| C | ASN76 | |
| D | ASN45 | |
| D | ASN76 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CROSSLNK: 5-imidazolinone (Ser-Gly) => ECO:0000269|PubMed:8448132 |
| Chain | Residue | Details |
| E | THR335 | |
| E | GLY335 |
