Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5B8B

Crystal structure of reduced chimeric E.coli AhpC1-186-YFSKHN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006979	biological_process	response to oxidative stress
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0009321	cellular_component	alkyl hydroperoxide reductase complex
A	0009970	biological_process	cellular response to sulfate starvation
A	0016020	cellular_component	membrane
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
A	0019290	biological_process	siderophore biosynthetic process
A	0032843	molecular_function	hydroperoxide reductase activity
A	0033194	biological_process	response to hydroperoxide
A	0033195	biological_process	response to alkyl hydroperoxide
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0042802	molecular_function	identical protein binding
A	0045454	biological_process	cell redox homeostasis
A	0051920	molecular_function	peroxiredoxin activity
A	0098869	biological_process	cellular oxidant detoxification
A	0102039	molecular_function	NADH-dependent peroxiredoxin activity
B	0004601	molecular_function	peroxidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006979	biological_process	response to oxidative stress
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0009321	cellular_component	alkyl hydroperoxide reductase complex
B	0009970	biological_process	cellular response to sulfate starvation
B	0016020	cellular_component	membrane
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
B	0019290	biological_process	siderophore biosynthetic process
B	0032843	molecular_function	hydroperoxide reductase activity
B	0033194	biological_process	response to hydroperoxide
B	0033195	biological_process	response to alkyl hydroperoxide
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0042802	molecular_function	identical protein binding
B	0045454	biological_process	cell redox homeostasis
B	0051920	molecular_function	peroxiredoxin activity
B	0098869	biological_process	cellular oxidant detoxification
B	0102039	molecular_function	NADH-dependent peroxiredoxin activity
C	0004601	molecular_function	peroxidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006979	biological_process	response to oxidative stress
C	0008379	molecular_function	thioredoxin peroxidase activity
C	0009321	cellular_component	alkyl hydroperoxide reductase complex
C	0009970	biological_process	cellular response to sulfate starvation
C	0016020	cellular_component	membrane
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
C	0019290	biological_process	siderophore biosynthetic process
C	0032843	molecular_function	hydroperoxide reductase activity
C	0033194	biological_process	response to hydroperoxide
C	0033195	biological_process	response to alkyl hydroperoxide
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0042802	molecular_function	identical protein binding
C	0045454	biological_process	cell redox homeostasis
C	0051920	molecular_function	peroxiredoxin activity
C	0098869	biological_process	cellular oxidant detoxification
C	0102039	molecular_function	NADH-dependent peroxiredoxin activity
D	0004601	molecular_function	peroxidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006979	biological_process	response to oxidative stress
D	0008379	molecular_function	thioredoxin peroxidase activity
D	0009321	cellular_component	alkyl hydroperoxide reductase complex
D	0009970	biological_process	cellular response to sulfate starvation
D	0016020	cellular_component	membrane
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
D	0019290	biological_process	siderophore biosynthetic process
D	0032843	molecular_function	hydroperoxide reductase activity
D	0033194	biological_process	response to hydroperoxide
D	0033195	biological_process	response to alkyl hydroperoxide
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0042802	molecular_function	identical protein binding
D	0045454	biological_process	cell redox homeostasis
D	0051920	molecular_function	peroxiredoxin activity
D	0098869	biological_process	cellular oxidant detoxification
D	0102039	molecular_function	NADH-dependent peroxiredoxin activity
E	0004601	molecular_function	peroxidase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006979	biological_process	response to oxidative stress
E	0008379	molecular_function	thioredoxin peroxidase activity
E	0009321	cellular_component	alkyl hydroperoxide reductase complex
E	0009970	biological_process	cellular response to sulfate starvation
E	0016020	cellular_component	membrane
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
E	0019290	biological_process	siderophore biosynthetic process
E	0032843	molecular_function	hydroperoxide reductase activity
E	0033194	biological_process	response to hydroperoxide
E	0033195	biological_process	response to alkyl hydroperoxide
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0042802	molecular_function	identical protein binding
E	0045454	biological_process	cell redox homeostasis
E	0051920	molecular_function	peroxiredoxin activity
E	0098869	biological_process	cellular oxidant detoxification
E	0102039	molecular_function	NADH-dependent peroxiredoxin activity
F	0004601	molecular_function	peroxidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006979	biological_process	response to oxidative stress
F	0008379	molecular_function	thioredoxin peroxidase activity
F	0009321	cellular_component	alkyl hydroperoxide reductase complex
F	0009970	biological_process	cellular response to sulfate starvation
F	0016020	cellular_component	membrane
F	0016209	molecular_function	antioxidant activity
F	0016491	molecular_function	oxidoreductase activity
F	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
F	0019290	biological_process	siderophore biosynthetic process
F	0032843	molecular_function	hydroperoxide reductase activity
F	0033194	biological_process	response to hydroperoxide
F	0033195	biological_process	response to alkyl hydroperoxide
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0042802	molecular_function	identical protein binding
F	0045454	biological_process	cell redox homeostasis
F	0051920	molecular_function	peroxiredoxin activity
F	0098869	biological_process	cellular oxidant detoxification
F	0102039	molecular_function	NADH-dependent peroxiredoxin activity
G	0004601	molecular_function	peroxidase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006979	biological_process	response to oxidative stress
G	0008379	molecular_function	thioredoxin peroxidase activity
G	0009321	cellular_component	alkyl hydroperoxide reductase complex
G	0009970	biological_process	cellular response to sulfate starvation
G	0016020	cellular_component	membrane
G	0016209	molecular_function	antioxidant activity
G	0016491	molecular_function	oxidoreductase activity
G	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
G	0019290	biological_process	siderophore biosynthetic process
G	0032843	molecular_function	hydroperoxide reductase activity
G	0033194	biological_process	response to hydroperoxide
G	0033195	biological_process	response to alkyl hydroperoxide
G	0042744	biological_process	hydrogen peroxide catabolic process
G	0042802	molecular_function	identical protein binding
G	0045454	biological_process	cell redox homeostasis
G	0051920	molecular_function	peroxiredoxin activity
G	0098869	biological_process	cellular oxidant detoxification
G	0102039	molecular_function	NADH-dependent peroxiredoxin activity
H	0004601	molecular_function	peroxidase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006979	biological_process	response to oxidative stress
H	0008379	molecular_function	thioredoxin peroxidase activity
H	0009321	cellular_component	alkyl hydroperoxide reductase complex
H	0009970	biological_process	cellular response to sulfate starvation
H	0016020	cellular_component	membrane
H	0016209	molecular_function	antioxidant activity
H	0016491	molecular_function	oxidoreductase activity
H	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
H	0019290	biological_process	siderophore biosynthetic process
H	0032843	molecular_function	hydroperoxide reductase activity
H	0033194	biological_process	response to hydroperoxide
H	0033195	biological_process	response to alkyl hydroperoxide
H	0042744	biological_process	hydrogen peroxide catabolic process
H	0042802	molecular_function	identical protein binding
H	0045454	biological_process	cell redox homeostasis
H	0051920	molecular_function	peroxiredoxin activity
H	0098869	biological_process	cellular oxidant detoxification
H	0102039	molecular_function	NADH-dependent peroxiredoxin activity
I	0004601	molecular_function	peroxidase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006979	biological_process	response to oxidative stress
I	0008379	molecular_function	thioredoxin peroxidase activity
I	0009321	cellular_component	alkyl hydroperoxide reductase complex
I	0009970	biological_process	cellular response to sulfate starvation
I	0016020	cellular_component	membrane
I	0016209	molecular_function	antioxidant activity
I	0016491	molecular_function	oxidoreductase activity
I	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
I	0019290	biological_process	siderophore biosynthetic process
I	0032843	molecular_function	hydroperoxide reductase activity
I	0033194	biological_process	response to hydroperoxide
I	0033195	biological_process	response to alkyl hydroperoxide
I	0042744	biological_process	hydrogen peroxide catabolic process
I	0042802	molecular_function	identical protein binding
I	0045454	biological_process	cell redox homeostasis
I	0051920	molecular_function	peroxiredoxin activity
I	0098869	biological_process	cellular oxidant detoxification
I	0102039	molecular_function	NADH-dependent peroxiredoxin activity
J	0004601	molecular_function	peroxidase activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006979	biological_process	response to oxidative stress
J	0008379	molecular_function	thioredoxin peroxidase activity
J	0009321	cellular_component	alkyl hydroperoxide reductase complex
J	0009970	biological_process	cellular response to sulfate starvation
J	0016020	cellular_component	membrane
J	0016209	molecular_function	antioxidant activity
J	0016491	molecular_function	oxidoreductase activity
J	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
J	0019290	biological_process	siderophore biosynthetic process
J	0032843	molecular_function	hydroperoxide reductase activity
J	0033194	biological_process	response to hydroperoxide
J	0033195	biological_process	response to alkyl hydroperoxide
J	0042744	biological_process	hydrogen peroxide catabolic process
J	0042802	molecular_function	identical protein binding
J	0045454	biological_process	cell redox homeostasis
J	0051920	molecular_function	peroxiredoxin activity
J	0098869	biological_process	cellular oxidant detoxification
J	0102039	molecular_function	NADH-dependent peroxiredoxin activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 A 201

Chain	Residue
A	PRO48
A	SER86
A	GLU87
A	THR88

site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 C 201

Chain	Residue
C	ILE22
C	GLU23
C	ASP28

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 D 201

Chain	Residue
D	GLU139
E	PHE77
D	ARG112
D	GLU115

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 D 202

Chain	Residue
D	PRO10
D	GLU26
D	LYS27

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 E 201

Chain	Residue
E	SER86
E	GLU87
E	THR88

site_id	AC6
Number of Residues	1
Details	binding site for residue SO4 E 202

Chain	Residue
E	LYS153

site_id	AC7
Number of Residues	4
Details	binding site for residue SO4 E 203

Chain	Residue
E	ASP144
F	SER146
F	ASP147
F	ARG150

site_id	AC8
Number of Residues	2
Details	binding site for residue SO4 E 204

Chain	Residue
E	THR6
E	LYS7

site_id	AC9
Number of Residues	2
Details	binding site for residue SO4 E 205

Chain	Residue
E	LYS17
E	TYR69

site_id	AD1
Number of Residues	4
Details	binding site for residue SO4 G 201

Chain	Residue
G	GLY19
G	GLU20
G	PHE21
G	LYS80

site_id	AD2
Number of Residues	1
Details	binding site for residue SO4 G 202

Chain	Residue
G	GLU30

site_id	AD3
Number of Residues	3
Details	binding site for residue SO4 G 203

Chain	Residue
F	PHE77
G	PRO40
G	GLU139

site_id	AD4
Number of Residues	3
Details	binding site for residue SO4 G 204

Chain	Residue
G	SER86
G	GLU87
G	THR88

site_id	AD5
Number of Residues	4
Details	binding site for residue SO4 H 201

Chain	Residue
H	ARG112
H	LEU117
H	GLU139
I	PHE77

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1550
Details	Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	10
Details	Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"PubMed","id":"11904290","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	30
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)