5B73

Crystal structure of human ZMYND8 PHD-Bromo-PWWP domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 501

Chain	Residue
A	CYS275
A	CYS278
A	CYS294
A	HIS298

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 502

Chain	Residue
A	CYS111
A	CYS114
A	HIS131
A	CYS134

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 503

Chain	Residue
A	CYS126
A	CYS147
A	CYS150
A	CYS123

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Functional Information from PROSITE/UniProt

site_id	PS01359
Number of Residues	40
Details	ZF_PHD_1 Zinc finger PHD-type signature. CwvChregqv.......................................LcCel..Cprv.YHakClrltsepegd...................................WfCpeC

Chain	Residue	Details
A	CYS111-CYS150

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	45
Details	ZN_FING: PHD-type => ECO:0000255|PROSITE-ProRule:PRU00146

Chain	Residue	Details
A	ASP108-ILE153

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site_id	SWS_FT_FI2
Number of Residues	11
Details	BINDING: BINDING => ECO:0000269|PubMed:28966017, ECO:0007744|PDB:5Y1Z

Chain	Residue	Details
A	CYS111
A	CYS278
A	CYS294
A	CYS114
A	CYS123
A	CYS126
A	HIS131
A	CYS134
A	CYS147
A	CYS150
A	CYS275

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	THR424

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER426

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS410

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