Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004518 | molecular_function | nuclease activity |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0004520 | molecular_function | DNA endonuclease activity |
| B | 0004527 | molecular_function | exonuclease activity |
| B | 0008408 | molecular_function | 3'-5' exonuclease activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0043571 | biological_process | maintenance of CRISPR repeat elements |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051607 | biological_process | defense response to virus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue K A 101 |
| Chain | Residue |
| A | A65 |
| A | U66 |
| A | HOH206 |
| A | HOH310 |
| A | HOH337 |
| B | THR1102 |
| B | HOH1740 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue K A 102 |
| Chain | Residue |
| A | HOH287 |
| B | GLN1350 |
| B | HOH1794 |
| A | A68 |
| A | HOH286 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue K A 103 |
| Chain | Residue |
| A | G21 |
| A | HOH263 |
| A | HOH285 |
| A | HOH312 |
| A | HOH370 |
| A | HOH379 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 104 |
| Chain | Residue |
| A | U50 |
| A | HOH234 |
| A | HOH235 |
| A | HOH255 |
| A | HOH260 |
| A | HOH351 |
| B | HOH1769 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 105 |
| Chain | Residue |
| A | G21 |
| A | HOH245 |
| A | HOH332 |
| A | HOH370 |
| B | HOH1879 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 106 |
| Chain | Residue |
| A | G18 |
| A | G19 |
| A | HOH217 |
| A | HOH327 |
| A | HOH373 |
| B | ARG71 |
| B | HOH1873 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 107 |
| Chain | Residue |
| A | G62 |
| A | U63 |
| A | U64 |
| A | HOH204 |
| A | HOH272 |
| A | HOH323 |
| B | ARG461 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue ACT A 108 |
| Chain | Residue |
| A | U66 |
| A | C67 |
| B | ARG1171 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue K B 1401 |
| Chain | Residue |
| B | LEU623 |
| B | THR624 |
| B | PHE626 |
| B | TYR656 |
| C | HOH127 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue K B 1402 |
| Chain | Residue |
| B | GLY361 |
| B | TYR362 |
| B | GLY365 |
| B | ALA367 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue K B 1403 |
| Chain | Residue |
| A | U22 |
| B | ASP364 |
| B | GLY365 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue K B 1404 |
| Chain | Residue |
| A | HOH206 |
| B | GLU57 |
| B | HOH1656 |
| B | HOH1773 |
| B | HOH1848 |
| B | HOH1862 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue K B 1405 |
| Chain | Residue |
| B | GLU108 |
| B | GLU109 |
| B | LYS111 |
| B | HOH1850 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue K B 1406 |
| Chain | Residue |
| B | ILE226 |
| B | LEU229 |
| B | GLU232 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue K B 1407 |
| Chain | Residue |
| B | GLU584 |
| B | ARG586 |
| B | ASN588 |
| B | HOH1852 |
| site_id | AD7 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 1408 |
| Chain | Residue |
| A | A52 |
| B | PHE1105 |
| B | ILE1168 |
| B | MET1169 |
| B | ARG1171 |
| B | SER1172 |
| B | HOH1575 |
| B | HOH1690 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1409 |
| Chain | Residue |
| B | SER1277 |
| B | LYS1278 |
| B | LEU1282 |
| B | ALA1283 |
| B | ASP1284 |
| B | LEU1287 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 1410 |
| Chain | Residue |
| B | VAL1139 |
| B | GLY1165 |
| B | ARG1218 |
| B | HOH1734 |
| D | HOH103 |
| site_id | AE1 |
| Number of Residues | 9 |
| Details | binding site for residue EDO B 1411 |
| Chain | Residue |
| B | HIS160 |
| B | ASN407 |
| B | ILE410 |
| B | HIS415 |
| B | HOH1550 |
| A | C20 |
| A | HOH281 |
| B | TYR136 |
| B | ARG139 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 17 |
| Details | Region: {"description":"ARM","evidences":[{"source":"PubMed","id":"24505130","evidenceCode":"ECO:0000303"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 47 |
| Details | Region: {"description":"RuvC-II","evidences":[{"source":"PubMed","id":"24505130","evidenceCode":"ECO:0000303"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Motif: {"description":"PAM substrate-binding","evidences":[{"source":"PubMed","id":"25079318","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For RuvC-like nuclease domain","evidences":[{"source":"PubMed","id":"24529477","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor for HNH nuclease domain","evidences":[{"source":"PubMed","id":"24529477","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24505130","evidenceCode":"ECO:0000269"}]} |
