Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051607 | biological_process | defense response to virus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1701 |
| Chain | Residue |
| A | CYS460 |
| A | CYS657 |
| A | CYS814 |
| A | CYS817 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 1702 |
| Chain | Residue |
| A | HOH2338 |
| A | PHE647 |
| A | ASP649 |
| A | HOH1850 |
| A | HOH2200 |
| A | HOH2206 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 1703 |
| Chain | Residue |
| A | ASN1248 |
| A | HOH1975 |
| A | HOH2003 |
| A | HOH2323 |
| A | HOH2369 |
| B | HOH534 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 1704 |
| Chain | Residue |
| A | LYS564 |
| A | PHE602 |
| A | HOH2267 |
| A | HOH2334 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 1705 |
| Chain | Residue |
| A | LYS366 |
| A | LYS370 |
| A | TRP395 |
| A | GLU399 |
| A | HOH2079 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 1706 |
| Chain | Residue |
| A | ASP11 |
| A | GLU903 |
| A | HIS1162 |
| A | HOH1851 |
| A | HOH1870 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 1707 |
| Chain | Residue |
| A | ASP66 |
| A | HOH1931 |
| B | A60 |
| B | HOH318 |
| B | HOH458 |
| B | HOH479 |
| B | HOH493 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 1708 |
| Chain | Residue |
| A | HOH1804 |
| A | HOH2088 |
| A | HOH2335 |
| A | HOH2342 |
| C | HOH111 |
| C | HOH117 |
| C | HOH157 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue CA A 1709 |
| Chain | Residue |
| A | ASP66 |
| A | HOH1808 |
| B | HOH267 |
| B | HOH288 |
| B | HOH368 |
| B | HOH398 |
| B | HOH458 |
| B | HOH520 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 1710 |
| Chain | Residue |
| A | VAL402 |
| A | HOH2283 |
| A | HOH2299 |
| B | U83 |
| B | HOH335 |
| B | HOH503 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 1711 |
| Chain | Residue |
| A | HOH1901 |
| A | HOH1906 |
| A | HOH2387 |
| B | HOH218 |
| B | HOH257 |
| B | HOH490 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 1712 |
| Chain | Residue |
| A | SER507 |
| A | HOH2286 |
| A | HOH2327 |
| B | HOH336 |
| B | HOH440 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 1713 |
| Chain | Residue |
| A | LYS1415 |
| A | ASP1417 |
| A | HOH1902 |
| A | HOH2332 |
| A | HOH2336 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 1714 |
| Chain | Residue |
| A | HOH1948 |
| A | HOH2059 |
| A | HOH2242 |
| B | HOH282 |
| B | HOH506 |
| C | HOH103 |
| C | HOH152 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 1715 |
| Chain | Residue |
| A | GLU1231 |
| A | ASN1234 |
| A | ASP1498 |
| A | SER1499 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1716 |
| Chain | Residue |
| A | LYS45 |
| A | TYR48 |
| A | LEU50 |
| A | LEU51 |
| A | VAL911 |
| A | HOH2153 |
| site_id | AD8 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 1717 |
| Chain | Residue |
| A | ASP90 |
| A | THR91 |
| A | TYR332 |
| A | ASN335 |
| A | PHE336 |
| A | TYR345 |
| A | HOH1914 |
| A | HOH2279 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1718 |
| Chain | Residue |
| A | HIS394 |
| A | LEU397 |
| A | GLY398 |
| A | HOH2016 |
| B | HOH226 |
| B | HOH370 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 1719 |
| Chain | Residue |
| A | LEU626 |
| A | TYR627 |
| A | ILE628 |
| A | TYR656 |
| A | ARG1093 |
| A | GLU1097 |
| A | HOH1990 |
| A | HOH2099 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1720 |
| Chain | Residue |
| A | ARG625 |
| A | TYR627 |
| A | SER1118 |
| A | PHE1119 |
| A | HOH1972 |
| A | HOH2165 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1721 |
| Chain | Residue |
| A | LYS459 |
| A | GLY645 |
| A | PHE647 |
| A | ASN658 |
| A | HOH1806 |
| A | HOH2080 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1722 |
| Chain | Residue |
| A | PRO1251 |
| A | TYR1265 |
| A | TYR1329 |
| B | EDO110 |
| B | EDO116 |
| B | HOH379 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1723 |
| Chain | Residue |
| A | ASN1089 |
| A | GLY1090 |
| A | HOH1892 |
| C | DC21 |
| C | DT22 |
| site_id | AE6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 1724 |
| Chain | Residue |
| A | SER105 |
| A | ILE107 |
| A | ASP406 |
| A | PRO447 |
| A | PRO448 |
| A | HOH2048 |
| A | HOH2066 |
| site_id | AE7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 1725 |
| Chain | Residue |
| A | LEU6 |
| A | SER21 |
| A | ALA22 |
| A | PHE23 |
| A | ASN37 |
| A | ASN877 |
| A | ASN880 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1726 |
| Chain | Residue |
| A | GLN478 |
| A | TYR530 |
| A | LYS531 |
| A | ASP534 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1727 |
| Chain | Residue |
| A | SER899 |
| A | ALA901 |
| A | PHE904 |
| A | ASN1089 |
| site_id | AF1 |
| Number of Residues | 8 |
| Details | binding site for residue ACT A 1728 |
| Chain | Residue |
| A | ASN1248 |
| A | SER1368 |
| A | ARG1370 |
| A | PHE1398 |
| A | HOH1977 |
| A | HOH2003 |
| B | C44 |
| B | HOH228 |
| site_id | AF2 |
| Number of Residues | 8 |
| Details | binding site for residue ACT A 1729 |
| Chain | Residue |
| A | GLN92 |
| A | THR1458 |
| A | TRP1459 |
| A | ASP1460 |
| A | ASN1462 |
| A | HOH1968 |
| A | HOH2195 |
| B | A50 |
| site_id | AF3 |
| Number of Residues | 7 |
| Details | binding site for residue NA B 101 |
| Chain | Residue |
| B | G28 |
| B | U30 |
| B | U45 |
| B | NA102 |
| B | HOH334 |
| B | HOH475 |
| B | HOH515 |
| site_id | AF4 |
| Number of Residues | 7 |
| Details | binding site for residue NA B 102 |
| Chain | Residue |
| B | U45 |
| B | NA101 |
| B | HOH260 |
| B | HOH279 |
| B | HOH474 |
| B | HOH475 |
| B | HOH514 |
| site_id | AF5 |
| Number of Residues | 7 |
| Details | binding site for residue CA B 103 |
| Chain | Residue |
| B | HOH210 |
| B | HOH236 |
| B | HOH262 |
| B | HOH269 |
| B | HOH307 |
| B | HOH366 |
| B | HOH504 |
| site_id | AF6 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 104 |
| Chain | Residue |
| A | HOH2356 |
| B | U93 |
| B | HOH455 |
| B | HOH461 |
| B | HOH481 |
| B | HOH529 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 105 |
| Chain | Residue |
| B | G74 |
| B | HOH283 |
| B | HOH343 |
| B | HOH390 |
| B | HOH399 |
| B | HOH501 |
| site_id | AF8 |
| Number of Residues | 7 |
| Details | binding site for residue CA B 106 |
| Chain | Residue |
| A | HOH2322 |
| B | HOH211 |
| B | HOH255 |
| B | HOH344 |
| B | HOH357 |
| B | HOH422 |
| B | HOH531 |
| site_id | AF9 |
| Number of Residues | 7 |
| Details | binding site for residue CA B 107 |
| Chain | Residue |
| A | HOH2021 |
| A | HOH2204 |
| A | HOH2385 |
| B | HOH222 |
| B | HOH361 |
| B | HOH485 |
| B | HOH513 |
| site_id | AG1 |
| Number of Residues | 8 |
| Details | binding site for residue CA B 108 |
| Chain | Residue |
| A | HOH2351 |
| A | HOH2379 |
| B | G20 |
| B | HOH206 |
| B | HOH221 |
| B | HOH403 |
| B | HOH425 |
| B | HOH533 |
| site_id | AG2 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 109 |
| Chain | Residue |
| B | U12 |
| B | G13 |
| B | HOH204 |
| B | HOH502 |
| C | HOH123 |
| site_id | AG3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 110 |
| Chain | Residue |
| A | TYR1265 |
| A | EDO1722 |
| B | C42 |
| B | G43 |
| B | HOH258 |
| B | HOH300 |
| site_id | AG4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 111 |
| Chain | Residue |
| A | ARG1404 |
| A | HOH2038 |
| B | G31 |
| B | C44 |
| B | U45 |
| B | HOH275 |
| site_id | AG5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 112 |
| Chain | Residue |
| A | ARG59 |
| A | ARG62 |
| A | HOH1931 |
| B | A61 |
| B | G62 |
| site_id | AG6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 113 |
| Chain | Residue |
| A | SER105 |
| A | TYR449 |
| B | U17 |
| B | HOH245 |
| B | HOH264 |
| B | HOH384 |
| site_id | AG7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 114 |
| Chain | Residue |
| A | GLY309 |
| B | G19 |
| B | G20 |
| B | HOH230 |
| B | HOH295 |
| B | HOH298 |
| C | HOH118 |
| site_id | AG8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 115 |
| Chain | Residue |
| A | ARG369 |
| B | G73 |
| B | C89 |
| B | HOH243 |
| B | HOH244 |
| B | HOH308 |
| B | HOH391 |
| site_id | AG9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 116 |
| Chain | Residue |
| A | TYR1329 |
| A | EDO1722 |
| B | C34 |
| B | C35 |
| B | G41 |
| B | HOH300 |
| site_id | AH1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 117 |
| Chain | Residue |
| A | MET52 |
| A | ARG55 |
| B | G69 |
| B | A70 |
| B | HOH248 |
| B | HOH394 |
| site_id | AH2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 118 |
| Chain | Residue |
| B | G28 |
| B | HOH202 |
| B | HOH260 |
| B | HOH279 |
| B | HOH475 |
| site_id | AH3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 119 |
| Chain | Residue |
| B | C32 |
| B | G33 |
| B | C34 |
| B | HOH281 |
| B | HOH310 |
| site_id | AH4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 120 |
| Chain | Residue |
| B | A71 |
| B | G94 |
| B | HOH223 |
| site_id | AH5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 121 |
| Chain | Residue |
| A | ARG455 |
| A | LYS456 |
| B | A71 |
| B | C89 |
| B | HOH244 |
| B | HOH262 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 50 |
| Details | Region: {"description":"RuvC-I","evidences":[{"source":"PubMed","id":"26875867","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Region: {"description":"ARM","evidences":[{"source":"PubMed","id":"23584588","evidenceCode":"ECO:0000303"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 41 |
| Details | Region: {"description":"RuvC-II","evidences":[{"source":"PubMed","id":"26875867","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Motif: {"description":"PAM-binding","evidences":[{"source":"PubMed","id":"26875867","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For RuvC-like nuclease domain","evidences":[{"source":"PubMed","id":"26875867","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q99ZW2","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17550600","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26875867","evidenceCode":"ECO:0000269"}]} |
