Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051607 | biological_process | defense response to virus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1701 |
| Chain | Residue |
| A | CYS460 |
| A | CYS657 |
| A | CYS814 |
| A | CYS817 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 1702 |
| Chain | Residue |
| A | HOH2368 |
| A | PHE647 |
| A | ASP649 |
| A | HOH2031 |
| A | HOH2189 |
| A | HOH2251 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 1703 |
| Chain | Residue |
| A | HOH2374 |
| B | HOH232 |
| B | HOH301 |
| B | HOH442 |
| B | HOH529 |
| B | HOH537 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 1704 |
| Chain | Residue |
| A | LYS564 |
| A | PHE602 |
| A | HOH2268 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 1705 |
| Chain | Residue |
| A | LYS366 |
| A | LYS370 |
| A | TRP395 |
| A | GLU399 |
| A | HOH2015 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 1706 |
| Chain | Residue |
| A | ASP11 |
| A | GLU903 |
| A | HIS1162 |
| A | HOH1839 |
| A | HOH1883 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 1707 |
| Chain | Residue |
| A | ASP66 |
| A | HOH2357 |
| B | A60 |
| B | HOH317 |
| B | HOH322 |
| B | HOH408 |
| B | HOH503 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 1708 |
| Chain | Residue |
| A | HOH1808 |
| A | HOH1984 |
| A | HOH2401 |
| A | HOH2409 |
| C | HOH210 |
| C | HOH229 |
| C | HOH264 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue CA A 1709 |
| Chain | Residue |
| A | ASP66 |
| A | HOH1818 |
| B | HOH284 |
| B | HOH303 |
| B | HOH338 |
| B | HOH377 |
| B | HOH408 |
| B | HOH525 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 1710 |
| Chain | Residue |
| A | VAL402 |
| A | HOH2319 |
| A | HOH2358 |
| B | U83 |
| B | HOH490 |
| B | HOH499 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 1711 |
| Chain | Residue |
| A | HOH1880 |
| A | HOH1893 |
| A | HOH2439 |
| B | HOH296 |
| B | HOH325 |
| B | HOH496 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 1712 |
| Chain | Residue |
| A | SER507 |
| A | HOH2367 |
| A | HOH2369 |
| B | HOH278 |
| B | HOH423 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 1713 |
| Chain | Residue |
| A | LYS1415 |
| A | ASP1417 |
| A | HOH2141 |
| A | HOH2379 |
| A | HOH2386 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 1714 |
| Chain | Residue |
| A | HOH1846 |
| A | HOH2045 |
| A | HOH2078 |
| A | HOH2195 |
| B | HOH250 |
| C | HOH204 |
| C | HOH258 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 1715 |
| Chain | Residue |
| A | GLU1231 |
| A | ASN1234 |
| A | ASP1498 |
| A | SER1499 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 1716 |
| Chain | Residue |
| A | HOH2160 |
| A | HOH2293 |
| A | HOH2332 |
| B | HOH283 |
| B | HOH345 |
| B | HOH481 |
| B | HOH516 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1717 |
| Chain | Residue |
| A | LYS45 |
| A | TYR48 |
| A | THR49 |
| A | LEU50 |
| A | LEU51 |
| A | VAL911 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 1718 |
| Chain | Residue |
| A | TYR332 |
| A | ASN335 |
| A | PHE336 |
| A | TYR345 |
| A | HOH1951 |
| A | ASP90 |
| A | THR91 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1719 |
| Chain | Residue |
| A | HIS394 |
| A | LEU397 |
| A | GLY398 |
| A | HOH1902 |
| A | HOH1942 |
| A | HOH2135 |
| site_id | AE2 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 1720 |
| Chain | Residue |
| A | LEU626 |
| A | TYR627 |
| A | ILE628 |
| A | TYR656 |
| A | ARG1093 |
| A | GLU1097 |
| A | HOH2090 |
| A | HOH2136 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1721 |
| Chain | Residue |
| A | ARG625 |
| A | TYR627 |
| A | SER1118 |
| A | PHE1119 |
| A | HOH1863 |
| A | HOH2101 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1722 |
| Chain | Residue |
| A | LYS459 |
| A | GLY645 |
| A | PHE647 |
| A | ASN658 |
| A | HOH1835 |
| A | HOH2274 |
| site_id | AE5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 1723 |
| Chain | Residue |
| A | PRO1251 |
| A | TYR1265 |
| A | TYR1329 |
| A | HOH1805 |
| A | HOH2085 |
| B | EDO109 |
| B | EDO115 |
| site_id | AE6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 1724 |
| Chain | Residue |
| A | SER105 |
| A | ILE107 |
| A | ASP406 |
| A | PRO447 |
| A | PRO448 |
| A | HOH1971 |
| A | HOH2077 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1725 |
| Chain | Residue |
| A | GLN478 |
| A | TYR530 |
| A | LYS531 |
| A | ASP534 |
| site_id | AE8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 1726 |
| Chain | Residue |
| A | LEU6 |
| A | SER21 |
| A | ALA22 |
| A | PHE23 |
| A | ASN37 |
| A | ASN877 |
| A | ASN880 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1727 |
| Chain | Residue |
| A | SER899 |
| A | ALA901 |
| A | PHE904 |
| A | ASN1089 |
| site_id | AF1 |
| Number of Residues | 8 |
| Details | binding site for residue ACT A 1728 |
| Chain | Residue |
| A | GLN92 |
| A | THR1458 |
| A | TRP1459 |
| A | ASP1460 |
| A | ASN1462 |
| A | HOH1974 |
| A | HOH2222 |
| B | A50 |
| site_id | AF2 |
| Number of Residues | 7 |
| Details | binding site for residue NA B 101 |
| Chain | Residue |
| B | G28 |
| B | U30 |
| B | U45 |
| B | NA102 |
| B | HOH288 |
| B | HOH510 |
| B | HOH519 |
| site_id | AF3 |
| Number of Residues | 8 |
| Details | binding site for residue NA B 102 |
| Chain | Residue |
| B | U45 |
| B | NA101 |
| B | HOH262 |
| B | HOH475 |
| B | HOH510 |
| B | HOH514 |
| B | HOH539 |
| B | HOH541 |
| site_id | AF4 |
| Number of Residues | 7 |
| Details | binding site for residue CA B 103 |
| Chain | Residue |
| B | HOH204 |
| B | HOH214 |
| B | HOH237 |
| B | HOH277 |
| B | HOH280 |
| B | HOH313 |
| B | HOH500 |
| site_id | AF5 |
| Number of Residues | 7 |
| Details | binding site for residue CA B 104 |
| Chain | Residue |
| A | HOH2381 |
| A | HOH2419 |
| B | U93 |
| B | HOH224 |
| B | HOH416 |
| B | HOH430 |
| B | HOH534 |
| site_id | AF6 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 105 |
| Chain | Residue |
| B | G74 |
| B | HOH268 |
| B | HOH354 |
| B | HOH362 |
| B | HOH444 |
| B | HOH506 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 106 |
| Chain | Residue |
| A | HOH1824 |
| B | HOH230 |
| B | HOH258 |
| B | HOH269 |
| B | HOH428 |
| B | HOH536 |
| site_id | AF8 |
| Number of Residues | 8 |
| Details | binding site for residue CA B 107 |
| Chain | Residue |
| A | HOH2398 |
| B | G20 |
| B | HOH243 |
| B | HOH246 |
| B | HOH312 |
| B | HOH395 |
| B | HOH533 |
| B | HOH535 |
| site_id | AF9 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 108 |
| Chain | Residue |
| B | U12 |
| B | G13 |
| B | HOH205 |
| B | HOH472 |
| C | HOH224 |
| site_id | AG1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 109 |
| Chain | Residue |
| A | TYR1265 |
| A | EDO1723 |
| B | C42 |
| B | G43 |
| B | HOH233 |
| B | HOH257 |
| site_id | AG2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 110 |
| Chain | Residue |
| A | ARG1404 |
| A | HOH2112 |
| B | G31 |
| B | C44 |
| B | U45 |
| B | HOH211 |
| site_id | AG3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 111 |
| Chain | Residue |
| A | ARG59 |
| A | ARG62 |
| B | A61 |
| B | G62 |
| B | HOH317 |
| site_id | AG4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 112 |
| Chain | Residue |
| A | SER105 |
| A | TYR449 |
| B | U17 |
| B | HOH248 |
| B | HOH302 |
| B | HOH350 |
| site_id | AG5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 113 |
| Chain | Residue |
| A | GLY309 |
| B | G19 |
| B | G20 |
| B | HOH215 |
| B | HOH221 |
| B | HOH227 |
| C | HOH218 |
| site_id | AG6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 114 |
| Chain | Residue |
| A | ARG369 |
| B | G73 |
| B | C89 |
| B | HOH222 |
| B | HOH293 |
| B | HOH352 |
| B | HOH403 |
| site_id | AG7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 115 |
| Chain | Residue |
| A | TYR1329 |
| A | EDO1723 |
| B | C34 |
| B | C35 |
| B | G41 |
| B | HOH257 |
| site_id | AG8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 116 |
| Chain | Residue |
| A | MET52 |
| A | ARG55 |
| A | LYS864 |
| A | HOH2317 |
| B | A64 |
| B | G69 |
| B | HOH279 |
| site_id | AG9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 117 |
| Chain | Residue |
| A | ARG455 |
| A | LYS456 |
| B | A71 |
| B | C72 |
| B | C89 |
| B | HOH222 |
| B | HOH280 |
| site_id | AH1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 118 |
| Chain | Residue |
| B | A71 |
| B | G94 |
| B | HOH201 |
| site_id | AH2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 119 |
| Chain | Residue |
| B | C32 |
| B | G33 |
| B | C34 |
| B | HOH297 |
| B | HOH413 |
| B | HOH464 |
| site_id | AH3 |
| Number of Residues | 8 |
| Details | binding site for residue ACT B 120 |
| Chain | Residue |
| A | ASN1248 |
| A | SER1368 |
| A | ARG1370 |
| A | PHE1398 |
| B | C44 |
| B | HOH232 |
| B | HOH247 |
| B | HOH281 |
| site_id | AH4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 101 |
| Chain | Residue |
| A | ASN1089 |
| A | GLY1090 |
| C | DC21 |
| C | DT22 |
| C | HOH208 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 50 |
| Details | Region: {"description":"RuvC-I","evidences":[{"source":"PubMed","id":"26875867","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Region: {"description":"ARM","evidences":[{"source":"PubMed","id":"23584588","evidenceCode":"ECO:0000303"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 41 |
| Details | Region: {"description":"RuvC-II","evidences":[{"source":"PubMed","id":"26875867","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Motif: {"description":"PAM-binding","evidences":[{"source":"PubMed","id":"26875867","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For RuvC-like nuclease domain","evidences":[{"source":"PubMed","id":"26875867","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q99ZW2","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17550600","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26875867","evidenceCode":"ECO:0000269"}]} |
