Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5B04

Crystal structure of the eukaryotic translation initiation factor 2B from Schizosaccharomyces pombe

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002183	biological_process	cytoplasmic translational initiation
A	0003743	molecular_function	translation initiation factor activity
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0030234	molecular_function	enzyme regulator activity
A	1904262	biological_process	negative regulation of TORC1 signaling
B	0002183	biological_process	cytoplasmic translational initiation
B	0003743	molecular_function	translation initiation factor activity
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
B	0006412	biological_process	translation
B	0006413	biological_process	translational initiation
B	0030234	molecular_function	enzyme regulator activity
B	1904262	biological_process	negative regulation of TORC1 signaling
C	0002183	biological_process	cytoplasmic translational initiation
C	0003743	molecular_function	translation initiation factor activity
C	0005085	molecular_function	guanyl-nucleotide exchange factor activity
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
C	0006412	biological_process	translation
C	0006413	biological_process	translational initiation
C	0006417	biological_process	regulation of translation
C	0030234	molecular_function	enzyme regulator activity
D	0002183	biological_process	cytoplasmic translational initiation
D	0003743	molecular_function	translation initiation factor activity
D	0005085	molecular_function	guanyl-nucleotide exchange factor activity
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
D	0006412	biological_process	translation
D	0006413	biological_process	translational initiation
D	0006417	biological_process	regulation of translation
D	0030234	molecular_function	enzyme regulator activity
E	0002183	biological_process	cytoplasmic translational initiation
E	0003743	molecular_function	translation initiation factor activity
E	0005085	molecular_function	guanyl-nucleotide exchange factor activity
E	0005515	molecular_function	protein binding
E	0005829	cellular_component	cytosol
E	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
E	0006412	biological_process	translation
E	0006413	biological_process	translational initiation
E	0009058	biological_process	biosynthetic process
F	0002183	biological_process	cytoplasmic translational initiation
F	0003743	molecular_function	translation initiation factor activity
F	0005085	molecular_function	guanyl-nucleotide exchange factor activity
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
F	0006412	biological_process	translation
F	0006413	biological_process	translational initiation
F	0009058	biological_process	biosynthetic process
G	0002183	biological_process	cytoplasmic translational initiation
G	0003743	molecular_function	translation initiation factor activity
G	0005085	molecular_function	guanyl-nucleotide exchange factor activity
G	0005515	molecular_function	protein binding
G	0005829	cellular_component	cytosol
G	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
G	0006412	biological_process	translation
G	0006413	biological_process	translational initiation
H	0002183	biological_process	cytoplasmic translational initiation
H	0003743	molecular_function	translation initiation factor activity
H	0005085	molecular_function	guanyl-nucleotide exchange factor activity
H	0005515	molecular_function	protein binding
H	0005829	cellular_component	cytosol
H	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
H	0006412	biological_process	translation
H	0006413	biological_process	translational initiation
I	0002183	biological_process	cytoplasmic translational initiation
I	0003743	molecular_function	translation initiation factor activity
I	0005085	molecular_function	guanyl-nucleotide exchange factor activity
I	0005515	molecular_function	protein binding
I	0005829	cellular_component	cytosol
I	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
I	0006412	biological_process	translation
I	0006413	biological_process	translational initiation
I	0009058	biological_process	biosynthetic process
I	0031369	molecular_function	translation initiation factor binding
J	0002183	biological_process	cytoplasmic translational initiation
J	0003743	molecular_function	translation initiation factor activity
J	0005085	molecular_function	guanyl-nucleotide exchange factor activity
J	0005515	molecular_function	protein binding
J	0005829	cellular_component	cytosol
J	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
J	0006412	biological_process	translation
J	0006413	biological_process	translational initiation
J	0009058	biological_process	biosynthetic process
J	0031369	molecular_function	translation initiation factor binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue PO4 A 401

Chain	Residue
A	SER145
A	ARG146
A	GLY147
A	LYS248

site_id	AC2
Number of Residues	3
Details	binding site for residue PO4 B 401

Chain	Residue
B	SER145
B	ARG146
B	LYS248

site_id	AC3
Number of Residues	4
Details	binding site for residue PO4 C 401

Chain	Residue
C	THR213
C	LYS315
C	SER211
C	LYS212

site_id	AC4
Number of Residues	4
Details	binding site for residue PO4 D 401

Chain	Residue
D	SER211
D	LYS212
D	THR213
D	LYS315

site_id	AC5
Number of Residues	5
Details	binding site for residue PO4 G 501

Chain	Residue
G	SER160
G	ASN161
G	SER277
G	SER278
G	PO4502

site_id	AC6
Number of Residues	6
Details	binding site for residue PO4 G 502

Chain	Residue
G	GLY159
G	SER160
G	ARG163
G	HIS344
G	TYR432
G	PO4501

site_id	AC7
Number of Residues	5
Details	binding site for residue PO4 H 501

Chain	Residue
H	GLY159
H	SER160
H	SER277
H	SER278
H	PO4502

site_id	AC8
Number of Residues	5
Details	binding site for residue PO4 H 502

Chain	Residue
H	SER160
H	HIS344
H	ARG355
H	TYR432
H	PO4501

site_id	AC9
Number of Residues	4
Details	binding site for residue PO4 I 701

Chain	Residue
I	ARG30
I	ARG171
I	ARG275
I	SER276

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18257517","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)