5AZG
Crystal structure of LGG-1 complexed with a UNC-51 peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000045 | biological_process | autophagosome assembly |
| A | 0000407 | cellular_component | phagophore assembly site |
| A | 0000421 | cellular_component | autophagosome membrane |
| A | 0000423 | biological_process | mitophagy |
| A | 0001778 | biological_process | plasma membrane repair |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0005776 | cellular_component | autophagosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006914 | biological_process | autophagy |
| A | 0006995 | biological_process | cellular response to nitrogen starvation |
| A | 0008340 | biological_process | determination of adult lifespan |
| A | 0008429 | molecular_function | phosphatidylethanolamine binding |
| A | 0009408 | biological_process | response to heat |
| A | 0012501 | biological_process | programmed cell death |
| A | 0016236 | biological_process | macroautophagy |
| A | 0030425 | cellular_component | dendrite |
| A | 0030670 | cellular_component | phagocytic vesicle membrane |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0040024 | biological_process | dauer larval development |
| A | 0043005 | cellular_component | neuron projection |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0043204 | cellular_component | perikaryon |
| A | 0050811 | molecular_function | GABA receptor binding |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0070266 | biological_process | necroptotic process |
| A | 0097237 | biological_process | cellular response to toxic substance |
| A | 0097352 | biological_process | autophagosome maturation |
| A | 0098792 | biological_process | xenophagy |
| A | 2000786 | biological_process | positive regulation of autophagosome assembly |
| B | 0000045 | biological_process | autophagosome assembly |
| B | 0000407 | cellular_component | phagophore assembly site |
| B | 0000421 | cellular_component | autophagosome membrane |
| B | 0000423 | biological_process | mitophagy |
| B | 0001778 | biological_process | plasma membrane repair |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005741 | cellular_component | mitochondrial outer membrane |
| B | 0005776 | cellular_component | autophagosome |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006914 | biological_process | autophagy |
| B | 0006995 | biological_process | cellular response to nitrogen starvation |
| B | 0008340 | biological_process | determination of adult lifespan |
| B | 0008429 | molecular_function | phosphatidylethanolamine binding |
| B | 0009408 | biological_process | response to heat |
| B | 0012501 | biological_process | programmed cell death |
| B | 0016236 | biological_process | macroautophagy |
| B | 0030425 | cellular_component | dendrite |
| B | 0030670 | cellular_component | phagocytic vesicle membrane |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0031625 | molecular_function | ubiquitin protein ligase binding |
| B | 0040024 | biological_process | dauer larval development |
| B | 0043005 | cellular_component | neuron projection |
| B | 0043025 | cellular_component | neuronal cell body |
| B | 0043202 | cellular_component | lysosomal lumen |
| B | 0043204 | cellular_component | perikaryon |
| B | 0050811 | molecular_function | GABA receptor binding |
| B | 0050830 | biological_process | defense response to Gram-positive bacterium |
| B | 0070266 | biological_process | necroptotic process |
| B | 0097237 | biological_process | cellular response to toxic substance |
| B | 0097352 | biological_process | autophagosome maturation |
| B | 0098792 | biological_process | xenophagy |
| B | 2000786 | biological_process | positive regulation of autophagosome assembly |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue CD A 201 |
| Chain | Residue |
| A | HIS0 |
| A | GLY116 |
| B | GLY-2 |
| B | HOH313 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue CD A 202 |
| Chain | Residue |
| A | GLU17 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue CD A 203 |
| Chain | Residue |
| B | HOH351 |
| A | ASP45 |
| A | HOH301 |
| B | HIS42 |
| B | HOH320 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue CD A 204 |
| Chain | Residue |
| A | ASP97 |
| A | HOH328 |
| B | ASP19 |
| B | HOH333 |
| B | HOH345 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue CD A 205 |
| Chain | Residue |
| A | HIS98 |
| A | HOH310 |
| A | HOH336 |
| A | HOH338 |
| A | HOH339 |
| A | HOH341 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue CD A 206 |
| Chain | Residue |
| A | ASP27 |
| B | ASP54 |
| B | HOH327 |
| B | HOH335 |
| B | HOH344 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue CD A 207 |
| Chain | Residue |
| A | HOH303 |
| B | HOH324 |
| B | HOH337 |
| B | HOH346 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue CD A 208 |
| Chain | Residue |
| A | ASP54 |
| B | ASP27 |
| B | HOH331 |
| B | HOH343 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue CD B 201 |
| Chain | Residue |
| A | GLY-2 |
| B | HIS0 |
| B | GLY116 |
| B | HOH313 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue CD B 202 |
| Chain | Residue |
| A | HIS99 |
| A | HOH311 |
| A | HOH335 |
| B | HIS99 |
| B | HOH340 |
| B | HOH347 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue CD B 203 |
| Chain | Residue |
| B | GLU17 |
| D | HOH406 |
| site_id | AD3 |
| Number of Residues | 1 |
| Details | binding site for residue CD B 204 |
| Chain | Residue |
| B | ASP111 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue CD B 205 |
| Chain | Residue |
| B | HIS98 |
| B | HOH302 |
| B | HOH311 |
| B | HOH338 |
| B | HOH349 |
| B | HOH354 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue CD B 206 |
| Chain | Residue |
| A | HIS42 |
| A | GLN69 |
| A | HOH302 |
| A | HOH340 |
| B | ASP45 |
| B | HOH321 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Site: {"description":"Required for the interaction with unc-51","evidences":[{"source":"PubMed","id":"26687600","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Site: {"description":"Required for interaction with sqst-1","evidences":[{"source":"PubMed","id":"26687600","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Lipidation: {"description":"Phosphatidylethanolamine amidated glycine","evidences":[{"source":"PubMed","id":"22767594","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20550938","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21802374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Motif: {"description":"LIR","evidences":[{"source":"PubMed","id":"26687600","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Required for interaction with lgg-1","evidences":[{"source":"PubMed","id":"26687600","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
