Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5AYX

Crystal structure of Human Quinolinate Phosphoribosyltransferase

Replaces: 3LAR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0009435	biological_process	NAD biosynthetic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0019674	biological_process	NAD metabolic process
A	0034213	biological_process	quinolinate catabolic process
A	0042802	molecular_function	identical protein binding
A	0070062	cellular_component	extracellular exosome
A	1902494	cellular_component	catalytic complex
B	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0009435	biological_process	NAD biosynthetic process
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0019363	biological_process	pyridine nucleotide biosynthetic process
B	0019674	biological_process	NAD metabolic process
B	0034213	biological_process	quinolinate catabolic process
B	0042802	molecular_function	identical protein binding
B	0070062	cellular_component	extracellular exosome
B	1902494	cellular_component	catalytic complex
C	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0009435	biological_process	NAD biosynthetic process
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0019363	biological_process	pyridine nucleotide biosynthetic process
C	0019674	biological_process	NAD metabolic process
C	0034213	biological_process	quinolinate catabolic process
C	0042802	molecular_function	identical protein binding
C	0070062	cellular_component	extracellular exosome
C	1902494	cellular_component	catalytic complex
D	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0009435	biological_process	NAD biosynthetic process
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0019363	biological_process	pyridine nucleotide biosynthetic process
D	0019674	biological_process	NAD metabolic process
D	0034213	biological_process	quinolinate catabolic process
D	0042802	molecular_function	identical protein binding
D	0070062	cellular_component	extracellular exosome
D	1902494	cellular_component	catalytic complex
E	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0009435	biological_process	NAD biosynthetic process
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
E	0019363	biological_process	pyridine nucleotide biosynthetic process
E	0019674	biological_process	NAD metabolic process
E	0034213	biological_process	quinolinate catabolic process
E	0042802	molecular_function	identical protein binding
E	0070062	cellular_component	extracellular exosome
E	1902494	cellular_component	catalytic complex
F	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0009435	biological_process	NAD biosynthetic process
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
F	0019363	biological_process	pyridine nucleotide biosynthetic process
F	0019674	biological_process	NAD metabolic process
F	0034213	biological_process	quinolinate catabolic process
F	0042802	molecular_function	identical protein binding
F	0070062	cellular_component	extracellular exosome
F	1902494	cellular_component	catalytic complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:26805589, ECO:0000305\|PubMed:17868694, ECO:0000305\|PubMed:24038671, ECO:0007744\|PDB:2JBM, ECO:0007744\|PDB:4KWW, ECO:0007744\|PDB:5AYY

Chain	Residue	Details
A	ARG102
B	ARG102
C	ARG102
D	ARG102
E	ARG102
F	ARG102

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:26805589, ECO:0000305\|PubMed:17868694, ECO:0000305\|PubMed:24038671, ECO:0007744\|PDB:2JBM, ECO:0007744\|PDB:4KWW, ECO:0007744\|PDB:5AYY, ECO:0007744\|PDB:5AYZ

Chain	Residue	Details
A	ARG138
E	HIS160
F	ARG138
F	HIS160
A	HIS160
B	ARG138
B	HIS160
C	ARG138
C	HIS160
D	ARG138
D	HIS160
E	ARG138

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:26805589, ECO:0000305\|PubMed:24038671, ECO:0007744\|PDB:2JBM, ECO:0007744\|PDB:4KWW, ECO:0007744\|PDB:5AYY, ECO:0007744\|PDB:5AYZ

Chain	Residue	Details
A	LYS171
B	LYS171
C	LYS171
D	LYS171
E	LYS171
F	LYS171

site_id	SWS_FT_FI4
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269\|PubMed:26805589, ECO:0007744\|PDB:5AYZ

Chain	Residue	Details
A	GLU201
C	ASP222
C	SER248
C	GLY270
D	GLU201
D	ASP222
D	SER248
D	GLY270
E	GLU201
E	ASP222
E	SER248
A	ASP222
E	GLY270
F	GLU201
F	ASP222
F	SER248
F	GLY270
A	SER248
A	GLY270
B	GLU201
B	ASP222
B	SER248
B	GLY270
C	GLU201

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)