5AYX

Crystal structure of Human Quinolinate Phosphoribosyltransferase

Replaces:  3LAR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0009435	biological_process	NAD+ biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0019674	biological_process	NAD+ metabolic process
A	0034213	biological_process	quinolinate catabolic process
A	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
A	0042802	molecular_function	identical protein binding
A	0070062	cellular_component	extracellular exosome
A	1902494	cellular_component	catalytic complex
B	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0009435	biological_process	NAD+ biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0019363	biological_process	pyridine nucleotide biosynthetic process
B	0019674	biological_process	NAD+ metabolic process
B	0034213	biological_process	quinolinate catabolic process
B	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
B	0042802	molecular_function	identical protein binding
B	0070062	cellular_component	extracellular exosome
B	1902494	cellular_component	catalytic complex
C	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0009435	biological_process	NAD+ biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0019363	biological_process	pyridine nucleotide biosynthetic process
C	0019674	biological_process	NAD+ metabolic process
C	0034213	biological_process	quinolinate catabolic process
C	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
C	0042802	molecular_function	identical protein binding
C	0070062	cellular_component	extracellular exosome
C	1902494	cellular_component	catalytic complex
D	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0009435	biological_process	NAD+ biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0019363	biological_process	pyridine nucleotide biosynthetic process
D	0019674	biological_process	NAD+ metabolic process
D	0034213	biological_process	quinolinate catabolic process
D	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
D	0042802	molecular_function	identical protein binding
D	0070062	cellular_component	extracellular exosome
D	1902494	cellular_component	catalytic complex
E	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0009435	biological_process	NAD+ biosynthetic process
E	0016740	molecular_function	transferase activity
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
E	0019363	biological_process	pyridine nucleotide biosynthetic process
E	0019674	biological_process	NAD+ metabolic process
E	0034213	biological_process	quinolinate catabolic process
E	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
E	0042802	molecular_function	identical protein binding
E	0070062	cellular_component	extracellular exosome
E	1902494	cellular_component	catalytic complex
F	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0009435	biological_process	NAD+ biosynthetic process
F	0016740	molecular_function	transferase activity
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
F	0019363	biological_process	pyridine nucleotide biosynthetic process
F	0019674	biological_process	NAD+ metabolic process
F	0034213	biological_process	quinolinate catabolic process
F	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
F	0042802	molecular_function	identical protein binding
F	0070062	cellular_component	extracellular exosome
F	1902494	cellular_component	catalytic complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Region: {"description":"Important for hexamer formation","evidences":[{"source":"PubMed","id":"26805589","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26805589","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17868694","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24038671","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2JBM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AYY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26805589","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17868694","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24038671","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2JBM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AYY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AYZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26805589","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24038671","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2JBM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AYY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AYZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26805589","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5AYZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---