5AXI
Crystal structure of Cbl-b TKB domain in complex with Cblin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001784 | molecular_function | phosphotyrosine residue binding |
| A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0023051 | biological_process | regulation of signaling |
| B | 0001784 | molecular_function | phosphotyrosine residue binding |
| B | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0007166 | biological_process | cell surface receptor signaling pathway |
| B | 0023051 | biological_process | regulation of signaling |
| C | 0001784 | molecular_function | phosphotyrosine residue binding |
| C | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0007166 | biological_process | cell surface receptor signaling pathway |
| C | 0023051 | biological_process | regulation of signaling |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 401 |
| Chain | Residue |
| A | ASP221 |
| A | THR223 |
| A | ASN225 |
| A | TYR227 |
| A | GLU232 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 402 |
| Chain | Residue |
| A | ARG183 |
| B | ARG183 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 403 |
| Chain | Residue |
| A | TRP243 |
| A | LYS175 |
| A | PRO242 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 404 |
| Chain | Residue |
| A | LYS189 |
| A | THR190 |
| A | ILE191 |
| A | HOH564 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 401 |
| Chain | Residue |
| B | ASP221 |
| B | THR223 |
| B | ASN225 |
| B | TYR227 |
| B | GLU232 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 402 |
| Chain | Residue |
| B | LYS175 |
| B | PRO242 |
| B | TRP243 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue CA C 401 |
| Chain | Residue |
| C | ASP221 |
| C | THR223 |
| C | ASN225 |
| C | TYR227 |
| C | GLU232 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide GLY E 2 and PTR E 3 |
| Chain | Residue |
| B | TYR266 |
| B | ARG286 |
| B | SER288 |
| B | CYS289 |
| B | THR290 |
| B | GLN308 |
| E | ASP1 |
| E | MET4 |
| E | HOH101 |
| E | HOH103 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide PTR E 3 and MET E 4 |
| Chain | Residue |
| B | TYR266 |
| B | ARG286 |
| B | SER288 |
| B | CYS289 |
| B | THR290 |
| B | GLN308 |
| B | THR309 |
| E | GLY2 |
| E | PRO5 |
| E | HOH101 |
| E | HOH103 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by INSR => ECO:0000250|UniProtKB:P35570 |
| Chain | Residue | Details |
| E | PTR3 | |
| B | GLU232 | |
| C | ASP221 | |
| C | THR223 | |
| C | ASN225 | |
| C | TYR227 | |
| C | GLU232 | |
| A | THR223 | |
| A | ASN225 | |
| A | TYR227 | |
| A | GLU232 | |
| B | ASP221 | |
| B | THR223 | |
| B | ASN225 | |
| B | TYR227 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG286 | |
| B | ARG286 | |
| C | ARG286 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine; by PKC/PRKCQ => ECO:0000250|UniProtKB:Q13191 |
| Chain | Residue | Details |
| A | SER282 | |
| B | SER282 | |
| C | SER282 |
