5AQC
KstR, transcriptional repressor of cholesterol degradation in Mycobacterium tuberculosis, bound to the cholesterol coenzyme A derivative, (25R)-3-oxocholest-4-en-26-oyl-CoA.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE 5JB A 230 |
| Chain | Residue |
| A | ILE96 |
| A | THR132 |
| A | ARG179 |
| A | SER182 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 5JB B 230 |
| Chain | Residue |
| B | TRP185 |
| B | HOH2064 |
| B | MET125 |
| B | TYR139 |
| B | GLU154 |
| B | ILE157 |
| B | SER182 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1217 |
| Chain | Residue |
| A | ARG61 |
| A | ASP101 |
| A | ARG102 |
| B | ARG61 |
| B | HOH2104 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MPD B 1218 |
| Chain | Residue |
| A | ARG196 |
| A | HOH2107 |
| B | VAL150 |
| B | ARG179 |
| B | SER182 |
| B | ASP183 |
| B | HOH2083 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD A 1216 |
| Chain | Residue |
| A | GLU169 |
| A | PRO170 |
| A | HOH2098 |
| B | LEU130 |
| B | TRP192 |
| B | ARG195 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1217 |
| Chain | Residue |
| B | MET125 |
| B | GLN126 |
| B | PRO129 |
| B | TRP192 |
| B | ALA199 |
| B | VAL202 |
| B | HOH2061 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 38 |
| Details | DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00335 |
| Chain | Residue | Details |
| A | GLN59-PHE78 | |
| B | GLN59-PHE78 |
