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5AP4

Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE O38 A 1795
ChainResidue
AILE531
ALEU654
AILE663
AMET671
A7PE1796
AGLN541
AALA551
AILE586
ACYS604
AGLY605
AASN606
AILE607
AASP608

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE 7PE A 1796
ChainResidue
ALYS553
AVAL555
ATYR568
AGLU571
AMET600
AILE663
AASP664
AMET671
AO381795

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE 7PE A 1797
ChainResidue
ATRP622
ALYS625
ASER626
ALYS629
AVAL791
AILE793
AGLN794

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 1798
ChainResidue
AILE549
ATYR550
ATYR589
AGLU603
ACYS604

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 1799
ChainResidue
AHIS639
APRO713
AILE782
APRO783

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues23
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGGSSKVFqVlnekkqi...........YAIK
ChainResidueDetails
AILE531-LYS553

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHsDLKpaNFLI
ChainResidueDetails
AILE643-ILE655

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues9
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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