5AOE
Crystal structure of pneumolysin D168A mutant.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008289 | molecular_function | lipid binding |
| A | 0015485 | molecular_function | cholesterol binding |
| A | 0020002 | cellular_component | host cell plasma membrane |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0090729 | molecular_function | toxin activity |
| A | 0141060 | biological_process | disruption of anatomical structure in another organism |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008289 | molecular_function | lipid binding |
| B | 0015485 | molecular_function | cholesterol binding |
| B | 0020002 | cellular_component | host cell plasma membrane |
| B | 0031640 | biological_process | killing of cells of another organism |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0090729 | molecular_function | toxin activity |
| B | 0141060 | biological_process | disruption of anatomical structure in another organism |
Functional Information from PROSITE/UniProt
| site_id | PS00481 |
| Number of Residues | 12 |
| Details | THIOL_CYTOLYSINS Thiol-activated cytolysins signature. RECTGLaWEWWR |
| Chain | Residue | Details |
| A | ARG426-ARG437 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 86 |
| Details | Transmembrane: {"description":"Beta stranded","evidences":[{"source":"UniProtKB","id":"Q04IN8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Motif: {"description":"Conserved undecapeptide","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Motif: {"description":"Cholesterol binding","evidences":[{"source":"UniProtKB","id":"P0C2E9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
