5AH2

The sliding clamp of Mycobacterium smegmatis in complex with a natural product.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005737	cellular_component	cytoplasm
A	0006260	biological_process	DNA replication
A	0006271	biological_process	DNA strand elongation involved in DNA replication
A	0008408	molecular_function	3'-5' exonuclease activity
A	0009360	cellular_component	DNA polymerase III complex
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0042802	molecular_function	identical protein binding
A	0046677	biological_process	response to antibiotic
A	0071897	biological_process	DNA biosynthetic process
B	0003677	molecular_function	DNA binding
B	0003887	molecular_function	DNA-directed DNA polymerase activity
B	0005737	cellular_component	cytoplasm
B	0006260	biological_process	DNA replication
B	0006271	biological_process	DNA strand elongation involved in DNA replication
B	0008408	molecular_function	3'-5' exonuclease activity
B	0009360	cellular_component	DNA polymerase III complex
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0042802	molecular_function	identical protein binding
B	0046677	biological_process	response to antibiotic
B	0071897	biological_process	DNA biosynthetic process
C	0003677	molecular_function	DNA binding
C	0003887	molecular_function	DNA-directed DNA polymerase activity
C	0005737	cellular_component	cytoplasm
C	0006260	biological_process	DNA replication
C	0006271	biological_process	DNA strand elongation involved in DNA replication
C	0008408	molecular_function	3'-5' exonuclease activity
C	0009360	cellular_component	DNA polymerase III complex
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0042802	molecular_function	identical protein binding
C	0046677	biological_process	response to antibiotic
C	0071897	biological_process	DNA biosynthetic process
D	0003677	molecular_function	DNA binding
D	0003887	molecular_function	DNA-directed DNA polymerase activity
D	0005737	cellular_component	cytoplasm
D	0006260	biological_process	DNA replication
D	0006271	biological_process	DNA strand elongation involved in DNA replication
D	0008408	molecular_function	3'-5' exonuclease activity
D	0009360	cellular_component	DNA polymerase III complex
D	0016740	molecular_function	transferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0042802	molecular_function	identical protein binding
D	0046677	biological_process	response to antibiotic
D	0071897	biological_process	DNA biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 1398

Chain	Residue
A	SER307
A	ALA308
A	ARG315
A	ALA316
A	HOH2228

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA C 1398

Chain	Residue
C	HOH2183
C	LEU44
C	SER55
C	GLU64
C	HOH2020

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site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR CHAIN E OF GRISELIMYCIN

Chain	Residue
A	MET161
A	ARG181
A	PHE182
A	ARG183
A	PRO257
A	LEU262
A	MET391
A	PRO392
A	VAL393
A	ARG394
A	HOH2267
A	HOH2271
A	HOH2272
A	HOH2273
D	TYR59
D	ASP123

---

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR CHAIN F OF GRISELIMYCIN

Chain	Residue
B	MET161
B	ARG181
B	PHE182
B	ARG183
B	PRO257
B	LEU262
B	MET391
B	PRO392
B	VAL393
B	ARG394
B	HOH2188
C	ILE37
C	TYR59
C	ASP123
C	ARG250

---

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR CHAIN G OF GRISELIMYCIN

Chain	Residue
B	THR36
B	ILE37
B	PRO38
B	TYR59
B	ASP123
B	ARG250
C	ARG181
C	PHE182
C	ARG183
C	GLN261
C	LEU262
C	MET391
C	PRO392
C	VAL393
C	ARG394
C	HOH2181

---

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR CHAIN H OF GRISELIMYCIN

Chain	Residue
A	THR36
A	ILE37
A	TYR59
A	ASP123
A	ARG250
D	MET161
D	ARG181
D	PHE182
D	ARG183
D	LEU262
D	MET391
D	PRO392
D	VAL393
D	ARG394
D	HOH2121
D	HOH2124

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