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5ABU

Complex of D. melanogaster eIF4E with the 4E-binding protein Mextli and cap analog

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003743molecular_functiontranslation initiation factor activity
A0005737cellular_componentcytoplasm
A0006413biological_processtranslational initiation
B0008190molecular_functioneukaryotic initiation factor 4E binding
B0045727biological_processpositive regulation of translation
Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE GTG A 1249
ChainResidue
ATRP89
AHOH2057
AHOH2058
BGLU584
BHIS585
BTYR588
BHOH2006
AMET92
AGLY121
AMET134
ATRP135
AGLU136
AARG188
ALYS193
AHOH2041

site_idAC2
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL B 1636
ChainResidue
BHIS585

Functional Information from PROSITE/UniProt
site_idPS00813
Number of Residues24
DetailsIF4E Eukaryotic initiation factor 4E signature. DYslFKknIrPmWEDaankqGGRW
ChainResidueDetails
AASP123-TRP146

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P06730
ChainResidueDetails
AASP100
ATRP146
AALA199

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PDB entries from 2024-11-06

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