5A8G

Crystal structure of the wild-type Staphylococcus aureus N- acetylneurminic acid lyase in complex with fluoropyruvate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0008747	molecular_function	N-acetylneuraminate lyase activity
A	0016829	molecular_function	lyase activity
A	0019262	biological_process	N-acetylneuraminate catabolic process
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0008747	molecular_function	N-acetylneuraminate lyase activity
B	0016829	molecular_function	lyase activity
B	0019262	biological_process	N-acetylneuraminate catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00666
Number of Residues	31
Details	DHDPS_2 Dihydrodipicolinate synthase signature 2. YAIPdlTgvnIsieqfselfnhek.IvGVKYT

Chain	Residue	Details
A	TYR137-THR167

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_01237

Chain	Residue	Details
A	TYR137
B	TYR137

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Schiff-base intermediate with substrate => ECO:0000255|HAMAP-Rule:MF_01237, ECO:0000269|PubMed:23418011

Chain	Residue	Details
A	KPF165
B	KPF165

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site_id	SWS_FT_FI3
Number of Residues	14
Details	BINDING: BINDING => ECO:0000305|PubMed:27943302, ECO:0007744|PDB:5KZD

Chain	Residue	Details
A	SER48
B	GLY189
B	ASP191
B	GLU192
B	SER208
B	TYR252
A	SER49
A	GLY189
A	ASP191
A	GLU192
A	SER208
A	TYR252
B	SER48
B	SER49

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