5A5Q

Crystal structure of human ATAD2 bromodomain in complex with 3-methyl- 8-piperidin-4-ylamino-1,2-dihydro-1,7-naphthyridin-2-one hydrochloride

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006325	biological_process	chromatin organization
A	0006355	biological_process	regulation of transcription, DNA-templated
A	0016887	molecular_function	ATP hydrolysis activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 2109

Chain	Residue
A	HIS998
A	GLU1091
A	GLU1092
A	LEU1093
A	ASP1094
A	HOH3203
A	HOH3207
A	HOH3230

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 2110

Chain	Residue
A	GLU1092
A	LEU1093
A	ASP1094
A	PHE1097
A	HOH3229
A	HOH3231
A	HOH3232
A	GLU988

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 6XC A 2111

Chain	Residue
A	VAL1008
A	VAL1013
A	GLU1017
A	ASN1064
A	ASP1071
A	ILE1074
A	HOH3110
A	HOH3114

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 2112

Chain	Residue
A	LEU1073
A	ARG1077
A	HOH3185
A	HOH3217

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 2113

Chain	Residue
A	ARG987
A	ARG990
A	ARG994
A	ARG1067
A	ARG1072
A	HOH3067
A	HOH3074
A	HOH3174

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