5A43
Crystal structure of a dual topology fluoride ion channel.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0062054 | molecular_function | fluoride channel activity |
| A | 0140114 | biological_process | cellular detoxification of fluoride |
| A | 1903424 | biological_process | fluoride transmembrane transport |
| A | 1903425 | molecular_function | fluoride transmembrane transporter activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0062054 | molecular_function | fluoride channel activity |
| B | 0140114 | biological_process | cellular detoxification of fluoride |
| B | 1903424 | biological_process | fluoride transmembrane transport |
| B | 1903425 | molecular_function | fluoride transmembrane transporter activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 1127 |
| Chain | Residue |
| A | GLY75 |
| A | SER78 |
| A | THR79 |
| B | GLY75 |
| B | SER78 |
| B | THR79 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE F B 1128 |
| Chain | Residue |
| B | PHE80 |
| B | SER81 |
| A | ASN41 |
| A | GLY45 |
| A | SER110 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE F A 1126 |
| Chain | Residue |
| A | SER81 |
| B | ASN41 |
| B | GLY45 |
| B | SER110 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE DMU B 1129 |
| Chain | Residue |
| A | ALA115 |
| A | PHE119 |
| B | PHE88 |
| B | LEU91 |
| B | GLN92 |
| B | GLY94 |
| B | TYR96 |
| C | PRO52 |
| C | SER54 |
| C | DMU1097 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMU A 1127 |
| Chain | Residue |
| A | LEU91 |
| A | GLN92 |
| A | GLY94 |
| A | TYR96 |
| B | PHE119 |
| D | PRO52 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMU C 1097 |
| Chain | Residue |
| B | DMU1129 |
| C | HIS32 |
| C | THR50 |
| C | PRO52 |
Functional Information from PROSITE/UniProt
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. GETGGNSP |
| Chain | Residue | Details |
| C | GLY38-PRO45 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 46 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"26344196","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5A43","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26344196","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5A43","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
