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5A3P

Crystal structure of the catalytic domain of human PLU1 (JARID1B).

Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 1755
ChainResidue
ACYS692
ACYS695
ACYS715
AHIS718

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 1756
ChainResidue
ACYS706
ACYS708
ACYS723
ACYS725

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN A 1757
ChainResidue
AASN91
ALEU413
ATHR416
AGLU419
AHOH2129
ALEU90

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN A 1758
ChainResidue
AHIS499
AGLU501
AHIS587
AHOH2285
AHOH2286
AHOH2291

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MN A 1759
ChainResidue
AHIS622
AHOH2499

site_idAC6
Number of Residues17
DetailsBINDING SITE FOR RESIDUE EPE A 1760
ChainResidue
AILE500
ATRP504
AGLU531
AMET534
ALEU541
APHE542
ALEU552
ATYR586
AHIS617
ATYR618
AARG623
AHOH2281
AHOH2290
AHOH2332
AHOH2367
AHOH2404
AHOH2532

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 1761
ChainResidue
ATRP486
ATYR488
AALA599
AVAL600
AHOH2286

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 1762
ChainResidue
AASP630
ACYS699
APHE700
AMET701
ASER702
AHOH2412

site_idAC9
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO A 1763
ChainResidue
AGLY426
AALA427
AASP428
APHE434
ALEU487
AVAL489
AHOH2209

site_idBC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 1764
ChainResidue
AARG666
ALEU732
ATYR734
ATHR737
AHOH2515
AHOH2534

site_idBC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 1765
ChainResidue
AARG612
AASP630
AMET658
AGLU662
ALEU665
AHOH2401

site_idBC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE EDO A 1766
ChainResidue
APRO30
AVAL568

site_idBC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE EDO A 1767
ChainResidue
AASP688
AGLU689
AARG690
AGLN691
AVAL693
AGLY711
ALEU713
AHOH2538

site_idBC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 1768
ChainResidue
AGLY524
ATYR525
AARG584
AHOH2320
AHOH2539

site_idBC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 1769
ChainResidue
AVAL674
AILE675
AHOH2201
AHOH2438

site_idBC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO A 1770
ChainResidue
ATYR425
ASER494
ASER495
AASN591
AHOH2208
AHOH2316
AHOH2540

site_idBC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 1771
ChainResidue
ATRP39
ATRP70
ASER457
AHOH2049

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues52
DetailsZN_FING: C5HC2 => ECO:0000269|PubMed:26741168, ECO:0000269|PubMed:27214403, ECO:0000269|PubMed:28262558
ChainResidueDetails
ACYS692-MET744

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P29375
ChainResidueDetails
ATYR425
ASER507
AASN509
ALYS517

site_idSWS_FT_FI3
Number of Residues3
DetailsBINDING: BINDING => ECO:0000305|PubMed:26741168, ECO:0000305|PubMed:27214403, ECO:0000305|PubMed:28262558
ChainResidueDetails
AHIS499
AGLU501
AHIS587

site_idSWS_FT_FI4
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS769

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PDB entries from 2024-11-06

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