5A3P

Crystal structure of the catalytic domain of human PLU1 (JARID1B).

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1755

Chain	Residue
A	CYS692
A	CYS695
A	CYS715
A	HIS718

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1756

Chain	Residue
A	CYS706
A	CYS708
A	CYS723
A	CYS725

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 1757

Chain	Residue
A	ASN91
A	LEU413
A	THR416
A	GLU419
A	HOH2129
A	LEU90

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 1758

Chain	Residue
A	HIS499
A	GLU501
A	HIS587
A	HOH2285
A	HOH2286
A	HOH2291

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MN A 1759

Chain	Residue
A	HIS622
A	HOH2499

---

site_id	AC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE EPE A 1760

Chain	Residue
A	ILE500
A	TRP504
A	GLU531
A	MET534
A	LEU541
A	PHE542
A	LEU552
A	TYR586
A	HIS617
A	TYR618
A	ARG623
A	HOH2281
A	HOH2290
A	HOH2332
A	HOH2367
A	HOH2404
A	HOH2532

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1761

Chain	Residue
A	TRP486
A	TYR488
A	ALA599
A	VAL600
A	HOH2286

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1762

Chain	Residue
A	ASP630
A	CYS699
A	PHE700
A	MET701
A	SER702
A	HOH2412

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1763

Chain	Residue
A	GLY426
A	ALA427
A	ASP428
A	PHE434
A	LEU487
A	VAL489
A	HOH2209

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1764

Chain	Residue
A	ARG666
A	LEU732
A	TYR734
A	THR737
A	HOH2515
A	HOH2534

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1765

Chain	Residue
A	ARG612
A	ASP630
A	MET658
A	GLU662
A	LEU665
A	HOH2401

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1766

Chain	Residue
A	PRO30
A	VAL568

---

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 1767

Chain	Residue
A	ASP688
A	GLU689
A	ARG690
A	GLN691
A	VAL693
A	GLY711
A	LEU713
A	HOH2538

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1768

Chain	Residue
A	GLY524
A	TYR525
A	ARG584
A	HOH2320
A	HOH2539

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1769

Chain	Residue
A	VAL674
A	ILE675
A	HOH2201
A	HOH2438

---

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1770

Chain	Residue
A	TYR425
A	SER494
A	SER495
A	ASN591
A	HOH2208
A	HOH2316
A	HOH2540

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1771

Chain	Residue
A	TRP39
A	TRP70
A	SER457
A	HOH2049

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	41
Details	Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	166
Details	Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	52
Details	Zinc finger: {"description":"C5HC2","evidences":[{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27214403","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28262558","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P29375","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27214403","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28262558","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---