5A3N

Crystal structure of human PLU-1 (JARID1B) in complex with KDOAM25a

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1754

Chain	Residue
A	CYS692
A	CYS695
A	CYS715
A	HIS718

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1755

Chain	Residue
A	CYS706
A	CYS708
A	CYS723
A	CYS725

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 1756

Chain	Residue
A	ASN91
A	LEU413
A	THR416
A	GLU419
A	LEU90

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN A 1757

Chain	Residue
A	GLU678
A	ARG735
A	HOH2399

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 1758

Chain	Residue
A	HIS499
A	GLU501
A	HIS587
A	LQT1759
A	HOH2210

---

site_id	AC6
Number of Residues	18
Details	BINDING SITE FOR RESIDUE LQT A 1759

Chain	Residue
A	ARG98
A	TYR425
A	TRP486
A	TYR488
A	PHE496
A	HIS499
A	GLU501
A	LYS517
A	TRP519
A	HIS587
A	VAL600
A	ASN601
A	MN1758
A	DMS1760
A	HOH2100
A	HOH2210
A	HOH2216
A	HOH2230

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS A 1760

Chain	Residue
A	ARG98
A	TYR425
A	TYR488
A	LQT1759
A	HOH2100
A	HOH2400

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 1761

Chain	Residue
A	HIS622
A	LYS694
A	HIS718
A	HOH2300
A	HOH2304

---

site_id	AC9
Number of Residues	18
Details	BINDING SITE FOR RESIDUE EPE A 1762

Chain	Residue
A	ILE500
A	TRP504
A	GLU531
A	MET534
A	LEU541
A	PHE542
A	LEU552
A	VAL553
A	TYR586
A	HIS617
A	TYR618
A	LEU621
A	ARG623
A	HOH2203
A	HOH2204
A	HOH2209
A	HOH2253
A	HOH2401

---

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO A 1763

Chain	Residue
A	ASP688
A	GLU689
A	ARG690
A	GLN691
A	VAL693
A	GLY711
A	LEU712
A	LEU713
A	HOH2403

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1764

Chain	Residue
A	ARG670
A	VAL674
A	ILE675
A	HOH2336
A	HOH2345

---

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 1765

Chain	Residue
A	ALA386
A	ASP387
A	LYS390
A	MET491
A	CYS492
A	GLU515
A	GLY593
A	PHE594

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1766

Chain	Residue
A	PHE74
A	ALA75
A	CYS76
A	GLY435
A	SER436

---

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 1767

Chain	Residue
A	HOH2369

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1768

Chain	Residue
A	HOH2404
A	LYS639
A	GLU678
A	LYS731

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	41
Details	Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	166
Details	Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	52
Details	Zinc finger: {"description":"C5HC2","evidences":[{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27214403","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28262558","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P29375","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27214403","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28262558","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---