4ZYY

Human GAR transformylase in complex with GAR and (S)-2-({5-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)butyl]thiophene-3-carbonyl}amino)pentanedioic acid (AGF118)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004644	molecular_function	phosphoribosylglycinamide formyltransferase activity
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0009058	biological_process	biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue GAR A 1101

Chain	Residue
A	THR817
A	GLU980
A	3YC1102
A	HOH1201
A	HOH1207
A	HOH1232
A	HOH1236
A	HOH1253
A	HOH1273
A	HOH1279
A	GLY818
A	SER819
A	ASN820
A	GLY894
A	HIS915
A	PRO916
A	GLY924
A	LYS977

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site_id	AC2
Number of Residues	16
Details	binding site for residue 3YC A 1102

Chain	Residue
A	ARG871
A	PHE895
A	MET896
A	ARG897
A	ILE898
A	LEU899
A	VAL904
A	HIS944
A	VAL946
A	ALA947
A	GLU948
A	VAL950
A	ASP951
A	GAR1101
A	HOH1238
A	HOH1272

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Functional Information from PROSITE/UniProt

site_id	PS00373
Number of Residues	24
Details	GART Phosphoribosylglycinamide formyltransferase active site. GcTVhFVaEdVDaGqiIlqeavpV

Chain	Residue	Details
A	GLY940-VAL963

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P08179

Chain	Residue	Details
A	HIS915

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:12450384, ECO:0000269|PubMed:16026156, ECO:0007744|PDB:1MEN, ECO:0007744|PDB:1ZLY

Chain	Residue	Details
A	GLY818
A	LYS977

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305|PubMed:12755606, ECO:0007744|PDB:1NJS

Chain	Residue	Details
A	ARG871
A	ASN913

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site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:16026156, ECO:0007744|PDB:1NJS, ECO:0007744|PDB:1ZLY

Chain	Residue	Details
A	MET896
A	ALA947

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Raises pKa of active site His => ECO:0000250|UniProtKB:P08179

Chain	Residue	Details
A	ASP951

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