4ZXF

Crystal Structure of a Soluble Variant of Monoglyceride Lipase from Saccharomyces Cerevisiae in Complex with a Substrate Analog

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005811	cellular_component	lipid droplet
A	0005886	cellular_component	plasma membrane
A	0006641	biological_process	triglyceride metabolic process
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0017171	molecular_function	serine hydrolase activity
A	0019433	biological_process	triglyceride catabolic process
A	0047372	molecular_function	monoacylglycerol lipase activity
A	0071944	cellular_component	cell periphery
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005811	cellular_component	lipid droplet
B	0005886	cellular_component	plasma membrane
B	0006641	biological_process	triglyceride metabolic process
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0017171	molecular_function	serine hydrolase activity
B	0019433	biological_process	triglyceride catabolic process
B	0047372	molecular_function	monoacylglycerol lipase activity
B	0071944	cellular_component	cell periphery
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005741	cellular_component	mitochondrial outer membrane
C	0005783	cellular_component	endoplasmic reticulum
C	0005811	cellular_component	lipid droplet
C	0005886	cellular_component	plasma membrane
C	0006641	biological_process	triglyceride metabolic process
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0017171	molecular_function	serine hydrolase activity
C	0019433	biological_process	triglyceride catabolic process
C	0047372	molecular_function	monoacylglycerol lipase activity
C	0071944	cellular_component	cell periphery
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005741	cellular_component	mitochondrial outer membrane
D	0005783	cellular_component	endoplasmic reticulum
D	0005811	cellular_component	lipid droplet
D	0005886	cellular_component	plasma membrane
D	0006641	biological_process	triglyceride metabolic process
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0017171	molecular_function	serine hydrolase activity
D	0019433	biological_process	triglyceride catabolic process
D	0047372	molecular_function	monoacylglycerol lipase activity
D	0071944	cellular_component	cell periphery

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 A 401

Chain	Residue
A	LYS187
A	ARG196
A	ARG280

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site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 B 401

Chain	Residue
B	LYS187
B	LYS193
B	ARG196
B	ARG280

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site_id	AC3
Number of Residues	14
Details	binding site for residue 4S7 C 500

Chain	Residue
C	SER123
C	MET124
C	LEU151
C	MET159
C	LYS162
C	GLN165
C	ILE166
C	LEU184
C	LEU208
C	PHE218
C	HIS281
D	MET159
C	GLY48
C	PHE49

---

site_id	AC4
Number of Residues	1
Details	binding site for residue NO3 D 401

Chain	Residue
A	PHE174

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site_id	AC5
Number of Residues	2
Details	binding site for residue NO3 D 402

Chain	Residue
D	LYS193
D	ARG196

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000305|PubMed:26869448

Chain	Residue	Details
A	SER123
B	SER123
C	SER123
D	SER123

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site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: Charge relay system => ECO:0000305|PubMed:26869448

Chain	Residue	Details
A	ASP251
A	HIS281
B	ASP251
B	HIS281
C	ASP251
C	HIS281
D	ASP251
D	HIS281

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