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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4ZVZ

Co-crystal structures of PP5 in complex with 5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016787	molecular_function	hydrolase activity
B	0016787	molecular_function	hydrolase activity
C	0016787	molecular_function	hydrolase activity
D	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MN A 501

Chain	Residue
A	ASP242
A	HIS244
A	ASP271
A	MN502
A	4TF503

site_id	AC2
Number of Residues	6
Details	binding site for residue MN A 502

Chain	Residue
A	MN501
A	4TF503
A	ASP271
A	ASN303
A	HIS352
A	HIS427

site_id	AC3
Number of Residues	15
Details	binding site for residue 4TF A 503

Chain	Residue
A	ASP242
A	HIS244
A	ASP271
A	ARG275
A	ASN303
A	HIS304
A	ARG400
A	HIS427
A	GLU428
A	VAL429
A	PHE446
A	TYR451
A	MN501
A	MN502
C	GLN454

site_id	AC4
Number of Residues	5
Details	binding site for residue MN B 501

Chain	Residue
B	ASP242
B	HIS244
B	ASP271
B	MN502
B	4TF503

site_id	AC5
Number of Residues	6
Details	binding site for residue MN B 502

Chain	Residue
B	ASP271
B	ASN303
B	HIS352
B	HIS427
B	MN501
B	4TF503

site_id	AC6
Number of Residues	16
Details	binding site for residue 4TF B 503

Chain	Residue
B	ASP242
B	HIS244
B	ASP271
B	ARG275
B	ASN303
B	HIS304
B	HIS352
B	ARG400
B	HIS427
B	GLU428
B	VAL429
B	PHE446
B	TYR451
B	MN501
B	MN502
D	GLN454

site_id	AC7
Number of Residues	5
Details	binding site for residue MN C 501

Chain	Residue
C	ASP242
C	HIS244
C	ASP271
C	MN502
C	4TF503

site_id	AC8
Number of Residues	6
Details	binding site for residue MN C 502

Chain	Residue
C	ASP271
C	ASN303
C	HIS352
C	HIS427
C	MN501
C	4TF503

site_id	AC9
Number of Residues	14
Details	binding site for residue 4TF C 503

Chain	Residue
C	ASP242
C	HIS244
C	ASP271
C	ARG275
C	ASN303
C	HIS304
C	ARG400
C	HIS427
C	GLU428
C	VAL429
C	PHE446
C	TYR451
C	MN501
C	MN502

site_id	AD1
Number of Residues	3
Details	binding site for residue NA C 504

Chain	Residue
C	ASN308
C	HIS463
C	HIS474

site_id	AD2
Number of Residues	6
Details	binding site for residue PEG C 505

Chain	Residue
C	LYS236
C	ASP307
C	GLU329
C	SER332
C	GLU333
C	GLU336

site_id	AD3
Number of Residues	5
Details	binding site for residue MN D 501

Chain	Residue
D	ASP242
D	HIS244
D	ASP271
D	MN502
D	4TF503

site_id	AD4
Number of Residues	6
Details	binding site for residue MN D 502

Chain	Residue
D	ASP271
D	ASN303
D	HIS352
D	HIS427
D	MN501
D	4TF503

site_id	AD5
Number of Residues	15
Details	binding site for residue 4TF D 503

Chain	Residue
D	ASP242
D	HIS244
D	ASP271
D	ARG275
D	ASN303
D	HIS304
D	ARG400
D	HIS427
D	GLU428
D	VAL429
D	PHE446
D	TYR451
D	MN501
D	MN502
B	GLN454

site_id	AD6
Number of Residues	2
Details	binding site for residue PEG D 504

Chain	Residue
D	PHE254
D	GLU255

Functional Information from PROSITE/UniProt

site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
A	LEU300-GLU305

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor/acceptor => ECO:0000269\|PubMed:15155720

Chain	Residue	Details
A	HIS304
B	HIS304
C	HIS304
D	HIS304

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:15155720, ECO:0000269\|PubMed:15577939, ECO:0000269\|PubMed:19601647, ECO:0007744\|PDB:1S95, ECO:0007744\|PDB:1WAO, ECO:0007744\|PDB:3H60, ECO:0007744\|PDB:3H61, ECO:0007744\|PDB:3H62, ECO:0007744\|PDB:3H63, ECO:0007744\|PDB:3H64

Chain	Residue	Details
A	ASP242
C	ASP271
C	ASN303
C	HIS352
D	ASP242
D	ASP271
D	ASN303
D	HIS352
A	ASP271
A	ASN303
A	HIS352
B	ASP242
B	ASP271
B	ASN303
B	HIS352
C	ASP242

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:15155720

Chain	Residue	Details
A	HIS244
C	ARG275
C	ARG400
C	HIS427
D	HIS244
D	ARG275
D	ARG400
D	HIS427
A	ARG275
A	ARG400
A	HIS427
B	HIS244
B	ARG275
B	ARG400
B	HIS427
C	HIS244

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	10
Details	M-CSA 472

Chain	Residue	Details
A	ASP242	metal ligand
A	HIS427	activator, metal ligand
A	HIS244	metal ligand
A	ASP271	metal ligand
A	ASP274	activator, proton donor
A	ARG275	transition state stabiliser
A	ASN303	metal ligand, transition state stabiliser
A	HIS304	proton acceptor, proton donor, proton relay
A	HIS352	metal ligand
A	ARG400	transition state stabiliser

site_id	MCSA2
Number of Residues	10
Details	M-CSA 472

Chain	Residue	Details
B	ASP242	metal ligand
B	HIS427	activator, metal ligand
B	HIS244	metal ligand
B	ASP271	metal ligand
B	ASP274	activator, proton donor
B	ARG275	transition state stabiliser
B	ASN303	metal ligand, transition state stabiliser
B	HIS304	proton acceptor, proton donor, proton relay
B	HIS352	metal ligand
B	ARG400	transition state stabiliser

site_id	MCSA3
Number of Residues	10
Details	M-CSA 472

Chain	Residue	Details
C	ASP242	metal ligand
C	HIS427	activator, metal ligand
C	HIS244	metal ligand
C	ASP271	metal ligand
C	ASP274	activator, proton donor
C	ARG275	transition state stabiliser
C	ASN303	metal ligand, transition state stabiliser
C	HIS304	proton acceptor, proton donor, proton relay
C	HIS352	metal ligand
C	ARG400	transition state stabiliser

site_id	MCSA4
Number of Residues	10
Details	M-CSA 472

Chain	Residue	Details
D	ASP242	metal ligand
D	HIS427	activator, metal ligand
D	HIS244	metal ligand
D	ASP271	metal ligand
D	ASP274	activator, proton donor
D	ARG275	transition state stabiliser
D	ASN303	metal ligand, transition state stabiliser
D	HIS304	proton acceptor, proton donor, proton relay
D	HIS352	metal ligand
D	ARG400	transition state stabiliser

227344

PDB entries from 2024-11-13

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