Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4ZUL

Structure ALDH7A1 complexed with alpha-aminoadipate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
A	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006081	biological_process	aldehyde metabolic process
A	0007605	biological_process	sensory perception of sound
A	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0019285	biological_process	glycine betaine biosynthetic process from choline
A	0042426	biological_process	choline catabolic process
A	0042802	molecular_function	identical protein binding
A	0070062	cellular_component	extracellular exosome
B	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
B	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0006081	biological_process	aldehyde metabolic process
B	0007605	biological_process	sensory perception of sound
B	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0019285	biological_process	glycine betaine biosynthetic process from choline
B	0042426	biological_process	choline catabolic process
B	0042802	molecular_function	identical protein binding
B	0070062	cellular_component	extracellular exosome
C	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
C	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005829	cellular_component	cytosol
C	0006081	biological_process	aldehyde metabolic process
C	0007605	biological_process	sensory perception of sound
C	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0019285	biological_process	glycine betaine biosynthetic process from choline
C	0042426	biological_process	choline catabolic process
C	0042802	molecular_function	identical protein binding
C	0070062	cellular_component	extracellular exosome
D	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
D	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005829	cellular_component	cytosol
D	0006081	biological_process	aldehyde metabolic process
D	0007605	biological_process	sensory perception of sound
D	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0019285	biological_process	glycine betaine biosynthetic process from choline
D	0042426	biological_process	choline catabolic process
D	0042802	molecular_function	identical protein binding
D	0070062	cellular_component	extracellular exosome
E	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
E	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005829	cellular_component	cytosol
E	0006081	biological_process	aldehyde metabolic process
E	0007605	biological_process	sensory perception of sound
E	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
E	0016491	molecular_function	oxidoreductase activity
E	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E	0019285	biological_process	glycine betaine biosynthetic process from choline
E	0042426	biological_process	choline catabolic process
E	0042802	molecular_function	identical protein binding
E	0070062	cellular_component	extracellular exosome
F	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
F	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005829	cellular_component	cytosol
F	0006081	biological_process	aldehyde metabolic process
F	0007605	biological_process	sensory perception of sound
F	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
F	0016491	molecular_function	oxidoreductase activity
F	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F	0019285	biological_process	glycine betaine biosynthetic process from choline
F	0042426	biological_process	choline catabolic process
F	0042802	molecular_function	identical protein binding
F	0070062	cellular_component	extracellular exosome
G	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
G	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005829	cellular_component	cytosol
G	0006081	biological_process	aldehyde metabolic process
G	0007605	biological_process	sensory perception of sound
G	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
G	0016491	molecular_function	oxidoreductase activity
G	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
G	0019285	biological_process	glycine betaine biosynthetic process from choline
G	0042426	biological_process	choline catabolic process
G	0042802	molecular_function	identical protein binding
G	0070062	cellular_component	extracellular exosome
H	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
H	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0005829	cellular_component	cytosol
H	0006081	biological_process	aldehyde metabolic process
H	0007605	biological_process	sensory perception of sound
H	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
H	0016491	molecular_function	oxidoreductase activity
H	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
H	0019285	biological_process	glycine betaine biosynthetic process from choline
H	0042426	biological_process	choline catabolic process
H	0042802	molecular_function	identical protein binding
H	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue PGE A 601

Chain	Residue
A	ARG68
A	TRP71
A	GLY158
A	ASN240

site_id	AC2
Number of Residues	13
Details	binding site for residue UN1 A 602

Chain	Residue
A	CYS302
A	THR303
A	GLY461
A	ALA462
A	PHE468
A	HOH706
A	HOH768
A	HOH820
A	GLU121
A	ASN167
A	PHE168
A	TRP175
A	ARG301

site_id	AC3
Number of Residues	5
Details	binding site for residue PGE B 601

Chain	Residue
B	ARG68
B	TRP71
B	VAL157
B	GLY158
B	ASN240

site_id	AC4
Number of Residues	15
Details	binding site for residue UN1 B 602

Chain	Residue
B	GLU121
B	PHE168
B	TRP175
B	ARG301
B	CYS302
B	THR303
B	SER460
B	GLY461
B	ALA462
B	PHE468
B	HOH724
B	HOH757
B	HOH764
B	HOH789
B	HOH859

site_id	AC5
Number of Residues	5
Details	binding site for residue PGE C 601

Chain	Residue
C	ARG68
C	TRP71
C	VAL157
C	GLU237
C	ASN240

site_id	AC6
Number of Residues	15
Details	binding site for residue UN1 C 602

Chain	Residue
C	GLU121
C	PHE168
C	TRP175
C	ARG301
C	CYS302
C	THR303
C	SER460
C	GLY461
C	ALA462
C	PHE468
C	HOH724
C	HOH728
C	HOH785
C	HOH808
C	HOH866

site_id	AC7
Number of Residues	4
Details	binding site for residue PGE D 601

Chain	Residue
D	ARG68
D	TRP71
D	GLU237
D	ASN240

site_id	AC8
Number of Residues	13
Details	binding site for residue UN1 D 602

Chain	Residue
D	GLU121
D	PHE168
D	TRP175
D	ARG301
D	CYS302
D	THR303
D	SER460
D	GLY461
D	ALA462
D	PHE468
D	HOH723
D	HOH750
D	HOH801

site_id	AC9
Number of Residues	4
Details	binding site for residue PG4 E 601

Chain	Residue
E	ARG68
E	TRP71
E	ASN240
E	HOH710

site_id	AD1
Number of Residues	15
Details	binding site for residue UN1 E 602

Chain	Residue
E	GLU121
E	ASN167
E	PHE168
E	TRP175
E	ARG301
E	CYS302
E	THR303
E	GLY461
E	ALA462
E	PHE468
E	HOH714
E	HOH721
E	HOH778
E	HOH806
E	HOH807

site_id	AD2
Number of Residues	3
Details	binding site for residue PGE F 601

Chain	Residue
F	ARG68
F	TRP71
F	ASN240

site_id	AD3
Number of Residues	14
Details	binding site for residue UN1 F 602

Chain	Residue
F	ARG301
F	CYS302
F	THR303
F	GLY461
F	ALA462
F	PHE468
F	HOH710
F	HOH721
F	HOH741
F	HOH840
F	HOH863
F	GLU121
F	PHE168
F	TRP175

site_id	AD4
Number of Residues	5
Details	binding site for residue PGE G 601

Chain	Residue
G	ARG68
G	TRP71
G	VAL157
G	GLU237
G	ASN240

site_id	AD5
Number of Residues	13
Details	binding site for residue UN1 G 602

Chain	Residue
G	GLU121
G	PHE168
G	TRP175
G	ARG301
G	CYS302
G	THR303
G	GLY461
G	ALA462
G	PHE468
G	HOH714
G	HOH746
G	HOH842
G	HOH894

site_id	AD6
Number of Residues	5
Details	binding site for residue PG4 H 601

Chain	Residue
H	ARG68
H	TRP71
H	GLY158
H	GLU237
H	ASN240

site_id	AD7
Number of Residues	6
Details	binding site for residue PGE H 602

Chain	Residue
H	TYR326
H	ILE329
H	VAL331
H	TYR369
H	ARG376
H	PRO383

site_id	AD8
Number of Residues	15
Details	binding site for residue UN1 H 603

Chain	Residue
H	GLU121
H	ASN167
H	PHE168
H	TRP175
H	ARG301
H	CYS302
H	THR303
H	SER460
H	GLY461
H	ALA462
H	PHE468
H	HOH717
H	HOH761
H	HOH773
H	HOH812

Functional Information from PROSITE/UniProt

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGNNA

Chain	Residue	Details
A	LEU267-ALA274

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU10007

Chain	Residue	Details
A	GLY296
B	GLY296
C	GLY296
D	GLY296
E	GLY296
F	GLY296
G	GLY296
H	GLY296

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: Nucleophile => ECO:0000269\|PubMed:26260980

Chain	Residue	Details
A	ARG330
B	ARG330
C	ARG330
D	ARG330
E	ARG330
F	ARG330
G	ARG330
H	ARG330

site_id	SWS_FT_FI3
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269\|PubMed:20207735, ECO:0000269\|PubMed:26260980, ECO:0007744\|PDB:2J6L, ECO:0007744\|PDB:4X0T, ECO:0007744\|PDB:4ZUK, ECO:0007744\|PDB:4ZVY

Chain	Residue	Details
A	ALA192
C	ALA218
C	VAL258
C	ALA274
D	ALA192
D	ALA218
D	VAL258
D	ALA274
E	ALA192
E	ALA218
E	VAL258
A	ALA218
E	ALA274
F	ALA192
F	ALA218
F	VAL258
F	ALA274
G	ALA192
G	ALA218
G	VAL258
G	ALA274
H	ALA192
A	VAL258
H	ALA218
H	VAL258
H	ALA274
A	ALA274
B	ALA192
B	ALA218
B	VAL258
B	ALA274
C	ALA192

site_id	SWS_FT_FI4
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:20207735, ECO:0000269\|PubMed:26260980, ECO:0007744\|PDB:2J6L, ECO:0007744\|PDB:4X0T

Chain	Residue	Details
A	GLY296
E	LEU427
F	GLY296
F	LEU427
G	GLY296
G	LEU427
H	GLY296
H	LEU427
A	LEU427
B	GLY296
B	LEU427
C	GLY296
C	LEU427
D	GLY296
D	LEU427
E	GLY296

site_id	SWS_FT_FI5
Number of Residues	24
Details	BINDING: BINDING => ECO:0007744\|PDB:4ZUL

Chain	Residue	Details
A	VAL331
D	VAL331
D	MET489
D	ARG490
E	VAL331
E	MET489
E	ARG490
F	VAL331
F	MET489
F	ARG490
G	VAL331
A	MET489
G	MET489
G	ARG490
H	VAL331
H	MET489
H	ARG490
A	ARG490
B	VAL331
B	MET489
B	ARG490
C	VAL331
C	MET489
C	ARG490

site_id	SWS_FT_FI6
Number of Residues	8
Details	SITE: Transition state stabilizer => ECO:0000250

Chain	Residue	Details
A	THR195
B	THR195
C	THR195
D	THR195
E	THR195
F	THR195
G	THR195
H	THR195

site_id	SWS_FT_FI7
Number of Residues	8
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:Q9DBF1

Chain	Residue	Details
A	ARG94
B	ARG94
C	ARG94
D	ARG94
E	ARG94
F	ARG94
G	ARG94
H	ARG94

site_id	SWS_FT_FI8
Number of Residues	16
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q9DBF1

Chain	Residue	Details
A	ALA462
E	LYS500
F	ALA462
F	LYS500
G	ALA462
G	LYS500
H	ALA462
H	LYS500
A	LYS500
B	ALA462
B	LYS500
C	ALA462
C	LYS500
D	ALA462
D	LYS500
E	ALA462

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)