4ZT5
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (2S)-N-(3,5-dichlorobenzyl)-N'-(1H-imidazo[4,5-b]pyridin-2-yl)-2-methylpropane-1,3-diamine (Chem 1655)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
A | 0004825 | molecular_function | methionine-tRNA ligase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
A | 0006431 | biological_process | methionyl-tRNA aminoacylation |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
B | 0004825 | molecular_function | methionine-tRNA ligase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
B | 0006431 | biological_process | methionyl-tRNA aminoacylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 10 |
Details | binding site for residue MET A 801 |
Chain | Residue |
A | ILE248 |
A | HOH922 |
A | TYR250 |
A | ASP287 |
A | TRP474 |
A | ALA477 |
A | TYR481 |
A | ILE519 |
A | HIS523 |
A | LYS550 |
site_id | AC2 |
Number of Residues | 2 |
Details | binding site for residue GOL A 802 |
Chain | Residue |
A | ARG583 |
A | ARG601 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue DMS A 803 |
Chain | Residue |
A | LYS521 |
A | ILE525 |
A | DMS804 |
A | DMS806 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue DMS A 804 |
Chain | Residue |
A | LYS517 |
A | ASP518 |
A | LEU520 |
A | LYS521 |
A | DMS803 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue DMS A 805 |
Chain | Residue |
A | TRP345 |
A | GLU349 |
A | PRO464 |
site_id | AC6 |
Number of Residues | 2 |
Details | binding site for residue DMS A 806 |
Chain | Residue |
A | LEU444 |
A | DMS803 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue GOL B 801 |
Chain | Residue |
B | ARG583 |
B | ARG601 |
B | HOH954 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue GOL B 802 |
Chain | Residue |
B | GLU239 |
B | ARG279 |
B | LYS442 |
B | GLY443 |
B | PRO445 |
B | GLU506 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue DMS B 803 |
Chain | Residue |
B | PHE319 |
B | TYR324 |
B | ILE326 |
B | HOH1072 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue DMS B 804 |
Chain | Residue |
B | GLY573 |
B | TYR574 |
B | ASP575 |
B | HOH948 |
site_id | AD2 |
Number of Residues | 4 |
Details | binding site for residue SO4 B 805 |
Chain | Residue |
B | ARG271 |
B | VAL275 |
B | SER714 |
B | PRO718 |
site_id | AD3 |
Number of Residues | 14 |
Details | binding site for residue 4RN B 806 |
Chain | Residue |
B | ILE248 |
B | TYR250 |
B | ASP287 |
B | HIS289 |
B | GLY290 |
B | VAL471 |
B | VAL473 |
B | TRP474 |
B | ASP476 |
B | TYR481 |
B | ILE519 |
B | HOH918 |
B | HOH922 |
B | HOH931 |