4ZRQ
E88 deletion mutant of CD320 in complex with TC2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006824 | biological_process | cobalt ion transport |
| A | 0009897 | cellular_component | external side of plasma membrane |
| A | 0015889 | biological_process | cobalamin transport |
| A | 0031419 | molecular_function | cobalamin binding |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0140104 | molecular_function | molecular carrier activity |
| A | 0140355 | molecular_function | cargo receptor ligand activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006824 | biological_process | cobalt ion transport |
| B | 0009897 | cellular_component | external side of plasma membrane |
| B | 0015889 | biological_process | cobalamin transport |
| B | 0031419 | molecular_function | cobalamin binding |
| B | 0043202 | cellular_component | lysosomal lumen |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0140104 | molecular_function | molecular carrier activity |
| B | 0140355 | molecular_function | cargo receptor ligand activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | binding site for residue CNC A 501 |
| Chain | Residue |
| A | GLY85 |
| A | MET270 |
| A | GLN273 |
| A | SER357 |
| A | LEU358 |
| A | SER359 |
| A | GLY360 |
| A | PRO361 |
| A | TYR362 |
| A | LEU363 |
| A | PHE376 |
| A | GLN86 |
| A | TRP377 |
| A | GLN378 |
| A | LEU379 |
| A | LEU387 |
| A | LEU388 |
| A | GLY390 |
| A | TRP409 |
| A | HOH605 |
| A | THR134 |
| A | TYR137 |
| A | GLN138 |
| A | ASP176 |
| A | ASN224 |
| A | TYR226 |
| A | SER227 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | SER174 |
| A | THR177 |
| A | TRP409 |
| A | HOH609 |
| A | HOH610 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | HIS169 |
| A | HIS172 |
| A | HIS173 |
| A | GLU211 |
| A | HOH612 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | GLY372 |
| A | GLU373 |
| A | GLU375 |
| B | GLY372 |
| B | GLU375 |
| site_id | AC5 |
| Number of Residues | 28 |
| Details | binding site for residue CNC B 501 |
| Chain | Residue |
| B | GLY85 |
| B | GLN86 |
| B | THR134 |
| B | TYR137 |
| B | GLN138 |
| B | ASP176 |
| B | ASN224 |
| B | TYR226 |
| B | SER227 |
| B | MET270 |
| B | GLN273 |
| B | SER357 |
| B | LEU358 |
| B | SER359 |
| B | GLY360 |
| B | PRO361 |
| B | TYR362 |
| B | LEU363 |
| B | PHE376 |
| B | TRP377 |
| B | GLN378 |
| B | LEU379 |
| B | LEU387 |
| B | LEU388 |
| B | GLY390 |
| B | TRP409 |
| B | HOH606 |
| B | HOH607 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| B | GLN63 |
| B | ARG102 |
| B | GLY103 |
| B | LYS105 |
| D | ASP77 |
| D | LEU78 |
| D | ASP79 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 201 |
| Chain | Residue |
| C | TRP150 |
| C | ASP153 |
| C | HIS155 |
| C | ASP157 |
| C | ASP163 |
| C | GLU164 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 202 |
| Chain | Residue |
| C | TRP72 |
| C | CYS74 |
| C | ASP75 |
| C | ASP77 |
| C | ASP79 |
| C | ASP85 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue CA D 201 |
| Chain | Residue |
| D | TRP150 |
| D | ASP153 |
| D | HIS155 |
| D | ASP157 |
| D | ASP163 |
| D | GLU164 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue CA D 202 |
| Chain | Residue |
| D | ASP85 |
| D | TRP72 |
| D | ASP75 |
| D | ASP77 |
| D | ASP79 |
Functional Information from PROSITE/UniProt
| site_id | PS00468 |
| Number of Residues | 14 |
| Details | COBALAMIN_BINDING Eukaryotic cobalamin-binding proteins signature. SVDTAAMAgLAFTC |
| Chain | Residue | Details |
| A | SER174-CYS187 |
| site_id | PS01209 |
| Number of Residues | 27 |
| Details | LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CVpltwr.CDrdlDCsdgsDEEcriepC |
| Chain | Residue | Details |
| C | CYS67-CYS94 | |
| C | CYS145-CYS167 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16537422","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27411955","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BB5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16537422","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BB5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"axial binding residue"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16537422","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 74 |
| Details | Domain: {"description":"LDL-receptor class A 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27411955","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ZRP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
