4ZRP

TC:CD320

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005886	cellular_component	plasma membrane
A	0006824	biological_process	cobalt ion transport
A	0009897	cellular_component	external side of plasma membrane
A	0015889	biological_process	cobalamin transport
A	0031419	molecular_function	cobalamin binding
A	0043202	cellular_component	lysosomal lumen
A	0046872	molecular_function	metal ion binding
A	0140355	molecular_function	cargo receptor ligand activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005886	cellular_component	plasma membrane
B	0006824	biological_process	cobalt ion transport
B	0009897	cellular_component	external side of plasma membrane
B	0015889	biological_process	cobalamin transport
B	0031419	molecular_function	cobalamin binding
B	0043202	cellular_component	lysosomal lumen
B	0046872	molecular_function	metal ion binding
B	0140355	molecular_function	cargo receptor ligand activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	35
Details	binding site for residue CNC A 501

Chain	Residue
A	GLY85
A	GLN273
A	SER357
A	LEU358
A	SER359
A	GLY360
A	PRO361
A	TYR362
A	LEU363
A	PHE376
A	TRP377
A	GLN86
A	GLN378
A	LEU379
A	LEU387
A	LEU388
A	GLY390
A	TRP409
A	CA503
A	GOL506
A	HOH616
A	HOH627
A	TYR137
A	HOH632
A	HOH637
A	HOH660
A	HOH666
A	HOH671
A	HOH762
A	GLN138
A	ASP176
A	ASN224
A	TYR226
A	SER227
A	MET270

---

site_id	AC2
Number of Residues	7
Details	binding site for residue CA A 502

Chain	Residue
A	GLU375
A	HOH631
A	HOH650
A	HOH799
B	GLU375
B	HOH722
B	HOH780

---

site_id	AC3
Number of Residues	6
Details	binding site for residue CA A 503

Chain	Residue
A	TYR226
A	ALA264
A	GLN266
A	ASN267
A	GLN389
A	CNC501

---

site_id	AC4
Number of Residues	3
Details	binding site for residue GOL A 504

Chain	Residue
A	ASP290
A	LEU292
B	ARG152

---

site_id	AC5
Number of Residues	5
Details	binding site for residue GOL A 505

Chain	Residue
A	ARG381
A	ASP382
A	ASN384
A	THR401
A	GLU403

---

site_id	AC6
Number of Residues	5
Details	binding site for residue GOL A 506

Chain	Residue
A	SER174
A	THR177
A	CNC501
A	HOH615
A	HOH659

---

site_id	AC7
Number of Residues	8
Details	binding site for residue GOL A 507

Chain	Residue
A	ARG41
A	LEU42
A	ALA96
A	PRO289
A	ASP290
A	CYS291
A	HOH604
A	HOH721

---

site_id	AC8
Number of Residues	5
Details	binding site for residue GOL A 508

Chain	Residue
A	GLN63
A	ARG102
A	HOH766
C	LEU78
C	ASP79

---

site_id	AC9
Number of Residues	32
Details	binding site for residue CNC B 501

Chain	Residue
B	HOH624
B	HOH629
B	HOH631
B	HOH633
B	HOH647
B	HOH661
B	HOH664
B	GLY85
B	GLN86
B	TYR137
B	GLN138
B	ASP176
B	ASN224
B	TYR226
B	SER227
B	MET270
B	GLN273
B	SER357
B	LEU358
B	SER359
B	GLY360
B	PRO361
B	TYR362
B	LEU363
B	PHE376
B	TRP377
B	GLN378
B	LEU379
B	LEU387
B	LEU388
B	GLY390
B	TRP409

---

site_id	AD1
Number of Residues	5
Details	binding site for residue GOL B 502

Chain	Residue
B	GLN63
B	ARG102
B	HOH683
D	LEU78
D	ASP79

---

site_id	AD2
Number of Residues	6
Details	binding site for residue CA C 201

Chain	Residue
C	TRP150
C	ASP153
C	HIS155
C	ASP157
C	ASP163
C	GLU164

---

site_id	AD3
Number of Residues	6
Details	binding site for residue CA C 202

Chain	Residue
C	TRP72
C	ASP75
C	ASP77
C	ASP79
C	ASP85
C	GLU86

---

site_id	AD4
Number of Residues	6
Details	binding site for residue CA D 201

Chain	Residue
D	TRP150
D	ASP153
D	HIS155
D	ASP157
D	ASP163
D	GLU164

---

site_id	AD5
Number of Residues	6
Details	binding site for residue CA D 202

Chain	Residue
D	TRP72
D	ASP75
D	ASP77
D	ASP79
D	ASP85
D	GLU86

---

Functional Information from PROSITE/UniProt

site_id	PS00468
Number of Residues	14
Details	COBALAMIN_BINDING Eukaryotic cobalamin-binding proteins signature. SVDTAAMAgLAFTC

Chain	Residue	Details
A	SER174-CYS187

---

site_id	PS01209
Number of Residues	23
Details	LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CVpltwr.CDrdlDCsdgsDEEe....C

Chain	Residue	Details
C	CYS67-CYS89
C	CYS145-CYS167

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:27411955, ECO:0007744|PDB:4ZRP

Chain	Residue	Details
C	TRP72
C	ASP157
C	ASP163
C	GLU164
D	TRP72
D	ASP75
D	ASP77
D	ASP79
D	ASP85
D	GLU86
D	TRP150
C	ASP75
D	ASP153
D	HIS155
D	ASP157
D	ASP163
D	GLU164
C	ASP77
C	ASP79
C	ASP85
C	GLU86
C	TRP150
C	ASP153
C	HIS155

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
C	ASN126
D	ASN126
A	TRP377
B	THR134
B	ASN224
B	TRP377

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: axial binding residue

Chain	Residue	Details
A	HIS172
B	HIS172

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:16537422

Chain	Residue	Details
A	GLN273
B	GLN273

---