4ZR5

Soluble rabbit neprilysin in complex with phosphoramidon

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001822	biological_process	kidney development
A	0004222	molecular_function	metalloendopeptidase activity
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0005903	cellular_component	brush border
A	0006508	biological_process	proteolysis
A	0006518	biological_process	peptide metabolic process
A	0008021	cellular_component	synaptic vesicle
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0010814	biological_process	substance P catabolic process
A	0010815	biological_process	bradykinin catabolic process
A	0016485	biological_process	protein processing
A	0016787	molecular_function	hydrolase activity
A	0019233	biological_process	sensory perception of pain
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0042277	molecular_function	peptide binding
A	0042447	biological_process	hormone catabolic process
A	0044306	cellular_component	neuron projection terminus
A	0045202	cellular_component	synapse
A	0046449	biological_process	creatinine metabolic process
A	0046872	molecular_function	metal ion binding
A	0050435	biological_process	amyloid-beta metabolic process
A	0071345	biological_process	cellular response to cytokine stimulus
A	0071492	biological_process	cellular response to UV-A
A	0071493	biological_process	cellular response to UV-B
A	0090399	biological_process	replicative senescence
A	0097242	biological_process	amyloid-beta clearance
B	0001822	biological_process	kidney development
B	0004222	molecular_function	metalloendopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0005903	cellular_component	brush border
B	0006508	biological_process	proteolysis
B	0006518	biological_process	peptide metabolic process
B	0008021	cellular_component	synaptic vesicle
B	0008233	molecular_function	peptidase activity
B	0008237	molecular_function	metallopeptidase activity
B	0008270	molecular_function	zinc ion binding
B	0010814	biological_process	substance P catabolic process
B	0010815	biological_process	bradykinin catabolic process
B	0016485	biological_process	protein processing
B	0016787	molecular_function	hydrolase activity
B	0019233	biological_process	sensory perception of pain
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0042277	molecular_function	peptide binding
B	0042447	biological_process	hormone catabolic process
B	0044306	cellular_component	neuron projection terminus
B	0045202	cellular_component	synapse
B	0046449	biological_process	creatinine metabolic process
B	0046872	molecular_function	metal ion binding
B	0050435	biological_process	amyloid-beta metabolic process
B	0071345	biological_process	cellular response to cytokine stimulus
B	0071492	biological_process	cellular response to UV-A
B	0071493	biological_process	cellular response to UV-B
B	0090399	biological_process	replicative senescence
B	0097242	biological_process	amyloid-beta clearance

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIGHEITHGF

Chain	Residue	Details
A	VAL581-PHE590

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1388
Details	Domain: {"description":"Peptidase M13","evidences":[{"source":"PROSITE-ProRule","id":"PRU01233","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01233","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01233","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P07861","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01233","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"3162886","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01233","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"UniProtKB","id":"P08473","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"}

Chain

Residue

Details

---