4ZR0
Full length scs7p (only hydroxylase domain visible)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000038 | biological_process | very long-chain fatty acid metabolic process |
| A | 0000170 | molecular_function | sphingosine hydroxylase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0006673 | biological_process | inositol phosphoceramide metabolic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008610 | biological_process | lipid biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0020037 | molecular_function | heme binding |
| A | 0044255 | biological_process | cellular lipid metabolic process |
| A | 0046513 | biological_process | ceramide biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0080132 | molecular_function | fatty acid alpha-hydroxylase activity |
| A | 0102771 | molecular_function | dihydroceramide fatty acyl 2-hydroxylase activity |
| B | 0000038 | biological_process | very long-chain fatty acid metabolic process |
| B | 0000170 | molecular_function | sphingosine hydroxylase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0006673 | biological_process | inositol phosphoceramide metabolic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0008610 | biological_process | lipid biosynthetic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0020037 | molecular_function | heme binding |
| B | 0044255 | biological_process | cellular lipid metabolic process |
| B | 0046513 | biological_process | ceramide biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0080132 | molecular_function | fatty acid alpha-hydroxylase activity |
| B | 0102771 | molecular_function | dihydroceramide fatty acyl 2-hydroxylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | HIS271 |
| A | HIS326 |
| A | HIS330 |
| A | HIS345 |
| A | HIS349 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 402 |
| Chain | Residue |
| A | HIS348 |
| A | HIS244 |
| A | HIS249 |
| A | HIS268 |
| A | HIS272 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 401 |
| Chain | Residue |
| B | HIS271 |
| B | HIS326 |
| B | HIS330 |
| B | HIS345 |
| B | HIS349 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 402 |
| Chain | Residue |
| B | HIS244 |
| B | HIS249 |
| B | HIS268 |
| B | HIS272 |
| B | HIS348 |
Functional Information from PROSITE/UniProt
| site_id | PS00191 |
| Number of Residues | 8 |
| Details | CYTOCHROME_B5_1 Cytochrome b5 family, heme-binding domain signature. FLSEHPGG |
| Chain | Residue | Details |
| A | PHE41-GLY48 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 576 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-ALA197 | |
| A | LEU247-PRO284 | |
| A | LEU329-GLU384 | |
| B | MET1-ALA197 | |
| B | LEU247-PRO284 | |
| B | LEU329-GLU384 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | TRANSMEM: Helical; Name=TM1 => ECO:0000269|PubMed:26515067 |
| Chain | Residue | Details |
| A | TRP198-ALA216 | |
| B | TRP198-ALA216 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | TOPO_DOM: Lumenal => ECO:0000305 |
| Chain | Residue | Details |
| A | LEU217-ASN221 | |
| A | LEU303-PRO304 | |
| B | LEU217-ASN221 | |
| B | LEU303-PRO304 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 48 |
| Details | TRANSMEM: Helical; Name=TM2 => ECO:0000269|PubMed:26515067 |
| Chain | Residue | Details |
| A | GLN222-PHE246 | |
| B | GLN222-PHE246 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 34 |
| Details | TRANSMEM: Helical; Name=TM3 => ECO:0000269|PubMed:26515067 |
| Chain | Residue | Details |
| A | PRO285-LEU302 | |
| B | PRO285-LEU302 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=TM4 => ECO:0000269|PubMed:26515067 |
| Chain | Residue | Details |
| A | LEU305-PHE328 | |
| B | LEU305-PHE328 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | BINDING: axial binding residue => ECO:0000255|PROSITE-ProRule:PRU00279 |
| Chain | Residue | Details |
| A | HIS45 | |
| A | HIS72 | |
| B | HIS45 | |
| B | HIS72 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26515067 |
| Chain | Residue | Details |
| A | HIS244 | |
| A | HIS349 | |
| B | HIS244 | |
| B | HIS249 | |
| B | HIS268 | |
| B | HIS271 | |
| B | HIS272 | |
| B | HIS326 | |
| B | HIS330 | |
| B | HIS345 | |
| B | HIS348 | |
| A | HIS249 | |
| B | HIS349 | |
| A | HIS268 | |
| A | HIS271 | |
| A | HIS272 | |
| A | HIS326 | |
| A | HIS330 | |
| A | HIS345 | |
| A | HIS348 |
