4ZO1

Crystal Structure of the T3-bound TR-beta Ligand-binding Domain in complex with RXR-alpha

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0003677	molecular_function	DNA binding
B	0003707	molecular_function	nuclear steroid receptor activity
B	0005634	cellular_component	nucleus
B	0006355	biological_process	regulation of DNA-templated transcription
B	0008270	molecular_function	zinc ion binding
X	0003677	molecular_function	DNA binding
X	0004879	molecular_function	nuclear receptor activity
X	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue T3 X 500

Chain	Residue
X	PHE272
X	GLY344
X	HIS435
X	PHE455
X	ILE276
X	ALA279
X	ARG282
X	ARG316
X	ARG320
X	THR329
X	LEU330
X	ASN331

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15466465","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Y0X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Motif: {"description":"LXXLL motif 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	20
Details	Region: {"description":"Required for nuclear export","evidences":[{"source":"PubMed","id":"15509776","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16107141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18800767","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19167885","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ACL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FC6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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