Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016311 | biological_process | dephosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue DVG A 501 |
| Chain | Residue |
| A | CYS403 |
| A | GLN450 |
| A | HOH628 |
| A | HOH663 |
| A | ARG404 |
| A | ALA405 |
| A | GLY406 |
| A | VAL407 |
| A | GLY408 |
| A | ARG409 |
| A | GLN446 |
| A | LYS447 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue VO4 A 502 |
| Chain | Residue |
| A | ARG278 |
| A | LYS342 |
| A | SER388 |
| A | SER389 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 503 |
| Chain | Residue |
| A | THR343 |
| A | MET382 |
| A | HOH654 |
| A | HOH686 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | MET317 |
| A | THR318 |
| A | GLN319 |
| A | ASP330 |
| A | MET331 |
| A | TYR332 |
Functional Information from PROSITE/UniProt
| site_id | PS00383 |
| Number of Residues | 11 |
| Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCraGvgRTA |
| Chain | Residue | Details |
| A | ILE401-ALA411 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Phosphocysteine intermediate |
| Chain | Residue | Details |
| A | CYS403 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 47 |
| Chain | Residue | Details |
| A | GLU290 | steric role |
| A | TYR354 | steric role |
| A | ASP356 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | HIS402 | electrostatic stabiliser, hydrogen bond donor |
| A | CYS403 | nucleofuge, nucleophile |
| A | ARG409 | electrostatic stabiliser, hydrogen bond donor |
| A | THR410 | electrostatic stabiliser, hydrogen bond donor |
