4ZLT

Crystal structure of viral chemokine binding protein R17 in complex with CCL3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
B	0005515	molecular_function	protein binding
F	0001649	biological_process	osteoblast differentiation
F	0001775	biological_process	cell activation
F	0002548	biological_process	monocyte chemotaxis
F	0004672	molecular_function	protein kinase activity
F	0005125	molecular_function	cytokine activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006468	biological_process	protein phosphorylation
F	0006816	biological_process	calcium ion transport
F	0006874	biological_process	intracellular calcium ion homeostasis
F	0006887	biological_process	exocytosis
F	0006935	biological_process	chemotaxis
F	0006954	biological_process	inflammatory response
F	0006955	biological_process	immune response
F	0007010	biological_process	cytoskeleton organization
F	0007186	biological_process	G protein-coupled receptor signaling pathway
F	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
F	0007267	biological_process	cell-cell signaling
F	0008009	molecular_function	chemokine activity
F	0008360	biological_process	regulation of cell shape
F	0009410	biological_process	response to xenobiotic stimulus
F	0009636	biological_process	response to toxic substance
F	0010628	biological_process	positive regulation of gene expression
F	0010629	biological_process	negative regulation of gene expression
F	0010818	biological_process	T cell chemotaxis
F	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F	0016004	molecular_function	phospholipase activator activity
F	0016301	molecular_function	kinase activity
F	0019722	biological_process	calcium-mediated signaling
F	0023052	biological_process	signaling
F	0030335	biological_process	positive regulation of cell migration
F	0030593	biological_process	neutrophil chemotaxis
F	0030595	biological_process	leukocyte chemotaxis
F	0032731	biological_process	positive regulation of interleukin-1 beta production
F	0032760	biological_process	positive regulation of tumor necrosis factor production
F	0042056	molecular_function	chemoattractant activity
F	0043067	biological_process	regulation of programmed cell death
F	0043308	biological_process	eosinophil degranulation
F	0043525	biological_process	positive regulation of neuron apoptotic process
F	0043615	biological_process	astrocyte cell migration
F	0043922	biological_process	negative regulation by host of viral transcription
F	0045671	biological_process	negative regulation of osteoclast differentiation
F	0045672	biological_process	positive regulation of osteoclast differentiation
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0048020	molecular_function	CCR chemokine receptor binding
F	0048245	biological_process	eosinophil chemotaxis
F	0048246	biological_process	macrophage chemotaxis
F	0048247	biological_process	lymphocyte chemotaxis
F	0050729	biological_process	positive regulation of inflammatory response
F	0050850	biological_process	positive regulation of calcium-mediated signaling
F	0050918	biological_process	positive chemotaxis
F	0051928	biological_process	positive regulation of calcium ion transport
F	0051930	biological_process	regulation of sensory perception of pain
F	0070098	biological_process	chemokine-mediated signaling pathway
F	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
F	0070723	biological_process	response to cholesterol
F	0071346	biological_process	cellular response to type II interferon
F	0071347	biological_process	cellular response to interleukin-1
F	0071356	biological_process	cellular response to tumor necrosis factor
F	0071621	biological_process	granulocyte chemotaxis
F	2000503	biological_process	positive regulation of natural killer cell chemotaxis
L	0001649	biological_process	osteoblast differentiation
L	0001775	biological_process	cell activation
L	0002548	biological_process	monocyte chemotaxis
L	0004672	molecular_function	protein kinase activity
L	0005125	molecular_function	cytokine activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006468	biological_process	protein phosphorylation
L	0006816	biological_process	calcium ion transport
L	0006874	biological_process	intracellular calcium ion homeostasis
L	0006887	biological_process	exocytosis
L	0006935	biological_process	chemotaxis
L	0006954	biological_process	inflammatory response
L	0006955	biological_process	immune response
L	0007010	biological_process	cytoskeleton organization
L	0007186	biological_process	G protein-coupled receptor signaling pathway
L	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
L	0007267	biological_process	cell-cell signaling
L	0008009	molecular_function	chemokine activity
L	0008360	biological_process	regulation of cell shape
L	0009410	biological_process	response to xenobiotic stimulus
L	0009636	biological_process	response to toxic substance
L	0010628	biological_process	positive regulation of gene expression
L	0010629	biological_process	negative regulation of gene expression
L	0010818	biological_process	T cell chemotaxis
L	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
L	0016004	molecular_function	phospholipase activator activity
L	0016301	molecular_function	kinase activity
L	0019722	biological_process	calcium-mediated signaling
L	0023052	biological_process	signaling
L	0030335	biological_process	positive regulation of cell migration
L	0030593	biological_process	neutrophil chemotaxis
L	0030595	biological_process	leukocyte chemotaxis
L	0032731	biological_process	positive regulation of interleukin-1 beta production
L	0032760	biological_process	positive regulation of tumor necrosis factor production
L	0042056	molecular_function	chemoattractant activity
L	0043067	biological_process	regulation of programmed cell death
L	0043308	biological_process	eosinophil degranulation
L	0043525	biological_process	positive regulation of neuron apoptotic process
L	0043615	biological_process	astrocyte cell migration
L	0043922	biological_process	negative regulation by host of viral transcription
L	0045671	biological_process	negative regulation of osteoclast differentiation
L	0045672	biological_process	positive regulation of osteoclast differentiation
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0048020	molecular_function	CCR chemokine receptor binding
L	0048245	biological_process	eosinophil chemotaxis
L	0048246	biological_process	macrophage chemotaxis
L	0048247	biological_process	lymphocyte chemotaxis
L	0050729	biological_process	positive regulation of inflammatory response
L	0050850	biological_process	positive regulation of calcium-mediated signaling
L	0050918	biological_process	positive chemotaxis
L	0051928	biological_process	positive regulation of calcium ion transport
L	0051930	biological_process	regulation of sensory perception of pain
L	0070098	biological_process	chemokine-mediated signaling pathway
L	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
L	0070723	biological_process	response to cholesterol
L	0071346	biological_process	cellular response to type II interferon
L	0071347	biological_process	cellular response to interleukin-1
L	0071356	biological_process	cellular response to tumor necrosis factor
L	0071621	biological_process	granulocyte chemotaxis
L	2000503	biological_process	positive regulation of natural killer cell chemotaxis

Functional Information from PROSITE/UniProt

site_id	PS00472
Number of Residues	41
Details	SMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCFsysrk...IprqfIvaYfetssl..Csqp.GVIFltkrnrqi.CA

Chain	Residue	Details
F	CYS11-ALA51

---