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4ZLO

Serine/threonine-protein kinase PAK1 complexed with a dibenzodiazepine: identification of an allosteric site on PAK1

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue 4PV A 601
ChainResidue
AGLU315
ATHR406
AGOL602
AVAL318
AMET319
AASN322
AILE327
AVAL328
AASN383
AHIS387
ALEU405

site_idAC2
Number of Residues7
Detailsbinding site for residue GOL A 602
ChainResidue
AMET319
AVAL328
AMET344
ATHR406
AASP407
APHE408
A4PV601

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGQGASGTVYtAmdvatgqe..........VAIK
ChainResidueDetails
AILE276-LYS299

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDIKsdNILL
ChainResidueDetails
AVAL385-LEU397

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000269|PubMed:22153498
ChainResidueDetails
AASP389
BASP389

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:22153498
ChainResidueDetails
AILE276
ALYS299
AGLU345
BILE276
BLYS299
BGLU345

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by JAK2 => ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089
ChainResidueDetails
ATYR285
BTYR285

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by autocatalysis, BRSK2 and PDPK1 => ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:10995762, ECO:0000269|PubMed:22153498, ECO:0000269|PubMed:22669945
ChainResidueDetails
ATPO423
BTPO423

218853

PDB entries from 2024-04-24

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