4ZKF
Crystal structure of human phosphodiesterase 12
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 701 |
| Chain | Residue |
| A | GLU351 |
| A | HOH823 |
| A | HOH865 |
| A | HOH881 |
| A | HOH892 |
| A | HOH1145 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 702 |
| Chain | Residue |
| A | HOH865 |
| A | HIS456 |
| A | ASP496 |
| A | ASN498 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 11 |
| Details | Compositional bias: {"description":"Low complexity","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"Q96LI5","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26055709","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2015","submissionDatabase":"PDB data bank","title":"Crystal structure of human phosphodiesterase.","authors":["Kim S.Y.","Kohno T.","Mori T.","Kitano K.","Hakoshima T."]}},{"source":"PDB","id":"4Z0V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZKF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2015","submissionDatabase":"PDB data bank","title":"Crystal structure of human phosphodiesterase.","authors":["Kim S.Y.","Kohno T.","Mori T.","Kitano K.","Hakoshima T."]}},{"source":"PDB","id":"4ZKF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
