4ZKA

High Resolution Crystal Structure of Fox1 RRM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0007399	biological_process	nervous system development
B	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
B	0003676	molecular_function	nucleic acid binding
B	0003723	molecular_function	RNA binding
B	0007399	biological_process	nervous system development
C	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
C	0003676	molecular_function	nucleic acid binding
C	0003723	molecular_function	RNA binding
C	0007399	biological_process	nervous system development
D	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
D	0003676	molecular_function	nucleic acid binding
D	0003723	molecular_function	RNA binding
D	0007399	biological_process	nervous system development
E	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
E	0003676	molecular_function	nucleic acid binding
E	0003723	molecular_function	RNA binding
E	0007399	biological_process	nervous system development
F	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
F	0003676	molecular_function	nucleic acid binding
F	0003723	molecular_function	RNA binding
F	0007399	biological_process	nervous system development

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue SO4 A 201

Chain	Residue
A	PHE18
A	ARG21
A	GLY46
A	SER47
A	HOH303
B	ARG63
B	GLU66
B	LYS67

---

site_id	AC2
Number of Residues	9
Details	binding site for residue MES A 202

Chain	Residue
A	GLY75
A	ARG76
B	GLY30
B	GLN31
B	PHE32
B	ASP60
B	SO4201
B	HOH361
A	GLU74

---

site_id	AC3
Number of Residues	9
Details	binding site for residue SO4 B 201

Chain	Residue
A	PRO17
A	PHE18
A	ARG19
A	ARG76
A	MES202
A	HOH322
B	ARG63
B	HOH325
B	HOH334

---

site_id	AC4
Number of Residues	9
Details	binding site for residue SO4 B 202

Chain	Residue
B	PHE18
B	ARG19
B	ARG21
B	GLY46
B	SER47
B	HOH301
B	HOH311
C	GLU74
C	GLY75

---

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 B 203

Chain	Residue
B	ARG45
B	HOH303
D	LYS34
D	GLU56

---

site_id	AC6
Number of Residues	5
Details	binding site for residue MES C 201

Chain	Residue
B	LYS5
C	LYS9
C	ASP62
C	ASN82
C	HOH301

---

site_id	AC7
Number of Residues	8
Details	binding site for residue SO4 D 201

Chain	Residue
D	PHE18
D	ARG21
D	GLY46
D	SER47
D	HOH306
E	ARG63
E	GLU66
E	LYS67

---

site_id	AC8
Number of Residues	8
Details	binding site for residue PG4 D 202

Chain	Residue
D	ASN15
D	GLY75
D	ARG76
E	GLN31
E	PHE32
E	ASP60
E	SO4201
E	HOH347

---

site_id	AC9
Number of Residues	10
Details	binding site for residue SO4 E 201

Chain	Residue
D	PRO17
D	PHE18
D	ARG19
D	ARG76
D	PG4202
D	HOH305
D	HOH319
E	ARG63
E	HOH324
E	HOH333

---

site_id	AD1
Number of Residues	4
Details	binding site for residue MES E 202

Chain	Residue
E	PRO17
E	PHE18
E	ARG19
E	ARG76

---

site_id	AD2
Number of Residues	6
Details	binding site for residue SO4 F 201

Chain	Residue
F	PRO17
F	PHE18
F	ARG76
F	HOH306
F	HOH308
F	HOH319

---

site_id	AD3
Number of Residues	8
Details	binding site for residue MES F 202

Chain	Residue
E	HOH353
F	PHE18
F	ARG45
F	HOH301
F	HOH310
F	HOH311
F	HOH314
F	HOH341

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	SITE: Interaction with RNA

Chain	Residue	Details
A	ARG10
B	PHE18
B	ARG19
B	ASN43
B	LYS48
B	PHE52
B	ARG76
B	ARG86
C	ARG10
C	PHE18
C	ARG19
A	PHE18
C	ASN43
C	LYS48
C	PHE52
C	ARG76
C	ARG86
D	ARG10
D	PHE18
D	ARG19
D	ASN43
D	LYS48
A	ARG19
D	PHE52
D	ARG76
D	ARG86
E	ARG10
E	PHE18
E	ARG19
E	ASN43
E	LYS48
E	PHE52
E	ARG76
A	ASN43
E	ARG86
F	ARG10
F	PHE18
F	ARG19
F	ASN43
F	LYS48
F	PHE52
F	ARG76
F	ARG86
A	LYS48
A	PHE52
A	ARG76
A	ARG86
B	ARG10

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