Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4ZIC

Crystal Structure of Aspartate Semialdehyde Dehydrogenase with NADP from Trichophyton rubrum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004073	molecular_function	aspartate-semialdehyde dehydrogenase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006520	biological_process	amino acid metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0009086	biological_process	methionine biosynthetic process
A	0009088	biological_process	threonine biosynthetic process
A	0009089	biological_process	lysine biosynthetic process via diaminopimelate
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0046983	molecular_function	protein dimerization activity
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
A	0071266	biological_process	'de novo' L-methionine biosynthetic process
B	0004073	molecular_function	aspartate-semialdehyde dehydrogenase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006520	biological_process	amino acid metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0009086	biological_process	methionine biosynthetic process
B	0009088	biological_process	threonine biosynthetic process
B	0009089	biological_process	lysine biosynthetic process via diaminopimelate
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0046983	molecular_function	protein dimerization activity
B	0050661	molecular_function	NADP binding
B	0051287	molecular_function	NAD binding
B	0071266	biological_process	'de novo' L-methionine biosynthetic process
C	0004073	molecular_function	aspartate-semialdehyde dehydrogenase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006520	biological_process	amino acid metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0009086	biological_process	methionine biosynthetic process
C	0009088	biological_process	threonine biosynthetic process
C	0009089	biological_process	lysine biosynthetic process via diaminopimelate
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0046983	molecular_function	protein dimerization activity
C	0050661	molecular_function	NADP binding
C	0051287	molecular_function	NAD binding
C	0071266	biological_process	'de novo' L-methionine biosynthetic process
D	0004073	molecular_function	aspartate-semialdehyde dehydrogenase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006520	biological_process	amino acid metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0009086	biological_process	methionine biosynthetic process
D	0009088	biological_process	threonine biosynthetic process
D	0009089	biological_process	lysine biosynthetic process via diaminopimelate
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0046983	molecular_function	protein dimerization activity
D	0050661	molecular_function	NADP binding
D	0051287	molecular_function	NAD binding
D	0071266	biological_process	'de novo' L-methionine biosynthetic process
E	0004073	molecular_function	aspartate-semialdehyde dehydrogenase activity
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006520	biological_process	amino acid metabolic process
E	0008652	biological_process	amino acid biosynthetic process
E	0009086	biological_process	methionine biosynthetic process
E	0009088	biological_process	threonine biosynthetic process
E	0009089	biological_process	lysine biosynthetic process via diaminopimelate
E	0016491	molecular_function	oxidoreductase activity
E	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E	0046983	molecular_function	protein dimerization activity
E	0050661	molecular_function	NADP binding
E	0051287	molecular_function	NAD binding
E	0071266	biological_process	'de novo' L-methionine biosynthetic process
F	0004073	molecular_function	aspartate-semialdehyde dehydrogenase activity
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006520	biological_process	amino acid metabolic process
F	0008652	biological_process	amino acid biosynthetic process
F	0009086	biological_process	methionine biosynthetic process
F	0009088	biological_process	threonine biosynthetic process
F	0009089	biological_process	lysine biosynthetic process via diaminopimelate
F	0016491	molecular_function	oxidoreductase activity
F	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F	0046983	molecular_function	protein dimerization activity
F	0050661	molecular_function	NADP binding
F	0051287	molecular_function	NAD binding
F	0071266	biological_process	'de novo' L-methionine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SO4 D 401

Chain	Residue
D	ARG114
D	ASN153
D	CYS154
D	LYS211
D	HOH541
D	HOH550
D	HOH556

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 C 401

Chain	Residue
C	CYS154
C	LYS211
C	NAP402
C	ARG114
C	ASN153

site_id	AC3
Number of Residues	18
Details	binding site for residue NAP C 402

Chain	Residue
C	THR15
C	GLY16
C	ALA17
C	VAL18
C	SER40
C	LEU87
C	ASP88
C	PRO89
C	ALA91
C	ASN109
C	ALA110
C	CYS154
C	GLY186
C	GLY188
C	ASN340
C	GLY344
C	ALA345
C	SO4401

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 401

Chain	Residue
A	ARG114
A	ASN153
A	CYS154
A	LYS211
A	NAP402

site_id	AC5
Number of Residues	30
Details	binding site for residue NAP A 402

Chain	Residue
A	GLY13
A	THR15
A	GLY16
A	ALA17
A	VAL18
A	ALA39
A	SER40
A	ARG53
A	ASP88
A	PRO89
A	ALA91
A	ASN109
A	ARG114
A	CYS154
A	VAL184
A	SER185
A	GLY186
A	ALA187
A	GLY188
A	TYR189
A	PRO190
A	GLY191
A	ASN340
A	GLY344
A	SO4401
A	HOH532
A	HOH558
A	HOH571
C	SER193
C	MET195

site_id	AC6
Number of Residues	5
Details	binding site for residue SO4 B 401

Chain	Residue
B	ARG114
B	ASN153
B	CYS154
B	LYS211
B	HOH543

site_id	AC7
Number of Residues	4
Details	binding site for residue SO4 E 401

Chain	Residue
E	ARG114
E	ASN153
E	CYS154
E	LYS211

site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 F 401

Chain	Residue
F	ARG114
F	ASN153
F	CYS154
F	LYS211
F	HOH520

site_id	AC9
Number of Residues	10
Details	binding site for Ligand ASN C 151 bound to ASN C 109

Chain	Residue
C	SER108
C	ASN109
C	ARG114
C	LEU121
C	VAL122
C	CYS150
C	SER152
C	ALA345
C	SER349
C	HOH511

Functional Information from PROSITE/UniProt

site_id	PS01103
Number of Residues	15
Details	ASD Aspartate-semialdehyde dehydrogenase signature. ISvaCnRVpvldGHT

Chain	Residue	Details
D	ILE238-THR252

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Acyl-thioester intermediate => ECO:0000255\|PIRSR:PIRSR000148-1

Chain	Residue	Details
D	CYS154
C	CYS154
A	CYS154
B	CYS154
E	CYS154
F	CYS154

site_id	SWS_FT_FI2
Number of Residues	6
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PIRSR:PIRSR000148-1

Chain	Residue	Details
D	HIS251
C	HIS251
A	HIS251
B	HIS251
E	HIS251
F	HIS251

site_id	SWS_FT_FI3
Number of Residues	30
Details	BINDING: BINDING => ECO:0000269\|PubMed:26869335, ECO:0007744\|PDB:4ZIC

Chain	Residue	Details
D	THR15
C	GLY186
A	THR15
A	SER40
A	LEU87
A	ASP88
A	GLY186
B	THR15
B	SER40
B	LEU87
B	ASP88
D	SER40
B	GLY186
E	THR15
E	SER40
E	LEU87
E	ASP88
E	GLY186
F	THR15
F	SER40
F	LEU87
F	ASP88
D	LEU87
F	GLY186
D	ASP88
D	GLY186
C	THR15
C	SER40
C	LEU87
C	ASP88

site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q5ALM0

Chain	Residue	Details
D	GLY16
E	SER43
F	GLY16
F	SER43
D	SER43
C	GLY16
C	SER43
A	GLY16
A	SER43
B	GLY16
B	SER43
E	GLY16

site_id	SWS_FT_FI5
Number of Residues	18
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:A0A179UL48

Chain	Residue	Details
D	ALA17
B	ALA17
B	VAL18
B	ASN340
E	ALA17
E	VAL18
E	ASN340
F	ALA17
F	VAL18
F	ASN340
D	VAL18
D	ASN340
C	ALA17
C	VAL18
C	ASN340
A	ALA17
A	VAL18
A	ASN340

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)