4ZI7
CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-HTI286 COMPLEX
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000226 | biological_process | microtubule cytoskeleton organization |
A | 0000278 | biological_process | mitotic cell cycle |
A | 0003924 | molecular_function | GTPase activity |
A | 0005200 | molecular_function | structural constituent of cytoskeleton |
A | 0005525 | molecular_function | GTP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005856 | cellular_component | cytoskeleton |
A | 0005874 | cellular_component | microtubule |
A | 0007017 | biological_process | microtubule-based process |
A | 0015630 | cellular_component | microtubule cytoskeleton |
A | 0016787 | molecular_function | hydrolase activity |
A | 0046872 | molecular_function | metal ion binding |
B | 0000226 | biological_process | microtubule cytoskeleton organization |
B | 0000278 | biological_process | mitotic cell cycle |
B | 0003924 | molecular_function | GTPase activity |
B | 0005200 | molecular_function | structural constituent of cytoskeleton |
B | 0005515 | molecular_function | protein binding |
B | 0005525 | molecular_function | GTP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005856 | cellular_component | cytoskeleton |
B | 0005874 | cellular_component | microtubule |
B | 0007017 | biological_process | microtubule-based process |
B | 0046872 | molecular_function | metal ion binding |
C | 0000226 | biological_process | microtubule cytoskeleton organization |
C | 0000278 | biological_process | mitotic cell cycle |
C | 0003924 | molecular_function | GTPase activity |
C | 0005200 | molecular_function | structural constituent of cytoskeleton |
C | 0005525 | molecular_function | GTP binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0005856 | cellular_component | cytoskeleton |
C | 0005874 | cellular_component | microtubule |
C | 0007017 | biological_process | microtubule-based process |
C | 0015630 | cellular_component | microtubule cytoskeleton |
C | 0016787 | molecular_function | hydrolase activity |
C | 0046872 | molecular_function | metal ion binding |
D | 0000226 | biological_process | microtubule cytoskeleton organization |
D | 0000278 | biological_process | mitotic cell cycle |
D | 0003924 | molecular_function | GTPase activity |
D | 0005200 | molecular_function | structural constituent of cytoskeleton |
D | 0005515 | molecular_function | protein binding |
D | 0005525 | molecular_function | GTP binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0005856 | cellular_component | cytoskeleton |
D | 0005874 | cellular_component | microtubule |
D | 0007017 | biological_process | microtubule-based process |
D | 0046872 | molecular_function | metal ion binding |
E | 0031110 | biological_process | regulation of microtubule polymerization or depolymerization |
F | 0036211 | biological_process | protein modification process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 27 |
Details | binding site for residue GTP A 501 |
Chain | Residue |
A | GLY10 |
A | GLY144 |
A | THR145 |
A | GLY146 |
A | VAL177 |
A | GLU183 |
A | ASN206 |
A | TYR224 |
A | ASN228 |
A | ILE231 |
A | MG502 |
A | GLN11 |
A | HOH603 |
A | HOH608 |
A | HOH619 |
A | HOH625 |
A | HOH628 |
A | HOH629 |
A | HOH637 |
B | LYS254 |
A | ALA12 |
A | GLN15 |
A | ASP98 |
A | ALA99 |
A | ASN101 |
A | SER140 |
A | GLY143 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue MG A 502 |
Chain | Residue |
A | GTP501 |
A | HOH603 |
A | HOH625 |
A | HOH628 |
A | HOH629 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue CA A 503 |
Chain | Residue |
A | ASP39 |
A | THR41 |
A | GLY44 |
A | GLU55 |
site_id | AC4 |
Number of Residues | 7 |
Details | binding site for residue GOL A 504 |
Chain | Residue |
A | SER158 |
A | GLY162 |
A | LYS164 |
A | LYS166 |
A | GLU196 |
A | HOH601 |
A | HOH602 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue GOL A 505 |
Chain | Residue |
A | ASN216 |
A | VAL275 |
A | ALA294 |
A | ASN300 |
A | HOH634 |
site_id | AC6 |
Number of Residues | 2 |
Details | binding site for residue GOL A 506 |
Chain | Residue |
A | ARG221 |
A | TYR224 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue GOL A 507 |
Chain | Residue |
A | ARG105 |
A | GLY410 |
A | GLU411 |
B | MES504 |
E | ARG61 |
site_id | AC8 |
Number of Residues | 24 |
Details | binding site for residue GDP B 501 |
Chain | Residue |
B | GLY10 |
B | GLN11 |
B | CYS12 |
B | GLN15 |
B | SER140 |
B | GLY143 |
B | GLY144 |
B | THR145 |
B | GLY146 |
B | PRO173 |
B | VAL177 |
B | GLU183 |
B | ASN206 |
B | TYR224 |
B | ASN228 |
B | MG502 |
B | HOH601 |
B | HOH602 |
B | HOH608 |
B | HOH611 |
B | HOH620 |
B | HOH623 |
B | HOH624 |
B | HOH632 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue MG B 502 |
Chain | Residue |
B | GLN11 |
B | GLU71 |
B | GDP501 |
B | HOH602 |
B | HOH608 |
site_id | AD1 |
Number of Residues | 1 |
Details | binding site for residue CA B 503 |
Chain | Residue |
B | GLU113 |
site_id | AD2 |
Number of Residues | 6 |
Details | binding site for residue MES B 504 |
Chain | Residue |
A | GOL507 |
B | ARG158 |
B | ARG164 |
B | ASN197 |
B | ASP199 |
B | ARG253 |
site_id | AD3 |
Number of Residues | 9 |
Details | binding site for residue MES B 505 |
Chain | Residue |
B | HOH609 |
B | PHE296 |
B | ASP297 |
B | ALA298 |
B | PRO307 |
B | ARG308 |
B | VAL335 |
B | ASN339 |
B | TYR342 |
site_id | AD4 |
Number of Residues | 3 |
Details | binding site for residue GOL B 506 |
Chain | Residue |
B | ARG401 |
C | GLU434 |
C | GOL506 |
site_id | AD5 |
Number of Residues | 15 |
Details | binding site for residue 4SL B 507 |
Chain | Residue |
B | PRO175 |
B | VAL177 |
B | ASP179 |
B | PRO222 |
B | THR223 |
B | TYR224 |
B | HOH604 |
B | HOH610 |
B | HOH613 |
B | HOH647 |
C | PRO325 |
C | ASN329 |
C | ILE332 |
C | PHE351 |
C | VAL353 |
site_id | AD6 |
Number of Residues | 2 |
Details | binding site for residue CA C 501 |
Chain | Residue |
B | ASP120 |
C | ASP218 |
site_id | AD7 |
Number of Residues | 26 |
Details | binding site for residue GTP C 502 |
Chain | Residue |
C | GLY10 |
C | GLN11 |
C | ALA12 |
C | GLN15 |
C | ASP98 |
C | ALA99 |
C | ASN101 |
C | SER140 |
C | GLY143 |
C | GLY144 |
C | THR145 |
C | GLY146 |
C | VAL177 |
C | GLU183 |
C | ASN206 |
C | TYR224 |
C | ASN228 |
C | ILE231 |
C | MG503 |
C | HOH605 |
C | HOH616 |
C | HOH617 |
C | HOH621 |
C | HOH629 |
C | HOH659 |
D | LYS254 |
site_id | AD8 |
Number of Residues | 5 |
Details | binding site for residue MG C 503 |
Chain | Residue |
C | GTP502 |
C | HOH605 |
C | HOH616 |
C | HOH621 |
C | HOH629 |
site_id | AD9 |
Number of Residues | 5 |
Details | binding site for residue CA C 504 |
Chain | Residue |
C | ASP39 |
C | THR41 |
C | GLY44 |
C | GLU55 |
C | HOH604 |
site_id | AE1 |
Number of Residues | 5 |
Details | binding site for residue GOL C 505 |
Chain | Residue |
C | ASP205 |
C | GLU207 |
C | LYS304 |
C | ARG390 |
C | HOH614 |
site_id | AE2 |
Number of Residues | 4 |
Details | binding site for residue GOL C 506 |
Chain | Residue |
B | GOL506 |
C | ASP431 |
C | VAL435 |
C | HOH609 |
site_id | AE3 |
Number of Residues | 21 |
Details | binding site for residue GDP D 501 |
Chain | Residue |
D | GLY10 |
D | GLN11 |
D | CYS12 |
D | GLN15 |
D | SER140 |
D | GLY143 |
D | GLY144 |
D | THR145 |
D | GLY146 |
D | VAL177 |
D | SER178 |
D | GLU183 |
D | ASN206 |
D | TYR224 |
D | ASN228 |
D | MG502 |
D | HOH601 |
D | HOH602 |
D | HOH603 |
D | HOH605 |
D | HOH608 |
site_id | AE4 |
Number of Residues | 5 |
Details | binding site for residue MG D 502 |
Chain | Residue |
D | GDP501 |
D | HOH602 |
D | HOH603 |
D | HOH605 |
D | HOH610 |
site_id | AE5 |
Number of Residues | 15 |
Details | binding site for residue ACP F 401 |
Chain | Residue |
F | LYS74 |
F | ILE148 |
F | GLN183 |
F | LYS184 |
F | TYR185 |
F | LEU186 |
F | LYS198 |
F | ASP200 |
F | ARG202 |
F | ARG222 |
F | THR241 |
F | ASN242 |
F | ASP318 |
F | GLU331 |
F | ASN333 |
site_id | AE6 |
Number of Residues | 6 |
Details | binding site for residue GOL F 402 |
Chain | Residue |
F | TYR211 |
F | ARG292 |
F | MET296 |
F | LEU378 |
F | HIS379 |
F | HIS380 |
Functional Information from PROSITE/UniProt
site_id | PS00227 |
Number of Residues | 7 |
Details | TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG |
Chain | Residue | Details |
B | GLY142-GLY148 | |
A | GLY142-GLY148 |
site_id | PS00228 |
Number of Residues | 4 |
Details | TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI |
Chain | Residue | Details |
B | MET1-ILE4 |
site_id | PS00563 |
Number of Residues | 10 |
Details | STATHMIN_1 Stathmin family signature 1. PRRRDpSLEE |
Chain | Residue | Details |
E | PRO40-GLU49 |
site_id | PS01041 |
Number of Residues | 10 |
Details | STATHMIN_2 Stathmin family signature 2. AEKREHEREV |
Chain | Residue | Details |
E | ALA73-VAL82 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903 |
Chain | Residue | Details |
E | SER46 | |
D | GLY144 | |
D | THR145 | |
D | GLY146 | |
D | ASN206 | |
D | ASN228 | |
B | SER140 | |
B | GLY144 | |
B | THR145 | |
B | GLY146 | |
B | ASN206 | |
B | ASN228 | |
D | GLN11 | |
D | SER140 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P68363 |
Chain | Residue | Details |
B | GLU71 | |
C | GLU71 | |
C | SER140 | |
C | GLY144 | |
C | THR145 | |
C | THR179 | |
C | ASN206 | |
C | ASN228 | |
D | GLU71 | |
A | SER140 | |
A | GLY144 | |
A | THR145 | |
A | THR179 | |
A | ASN206 | |
A | ASN228 | |
C | GLN11 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P99024 |
Chain | Residue | Details |
B | SER40 | |
D | SER40 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P99024 |
Chain | Residue | Details |
B | LYS60 | |
D | LYS60 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by CDK1 => ECO:0000250|UniProtKB:Q13885 |
Chain | Residue | Details |
B | SER174 | |
D | SER174 | |
C | SER48 | |
C | SER232 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P07437 |
Chain | Residue | Details |
B | THR287 | |
B | THR292 | |
D | THR287 | |
D | THR292 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:P07437 |
Chain | Residue | Details |
B | ARG320 | |
D | ARG320 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:Q2T9S0 |
Chain | Residue | Details |
B | GLU448 | |
D | GLU448 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P07437 |
Chain | Residue | Details |
B | LYS60 | |
D | LYS60 |
site_id | SWS_FT_FI10 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P07437 |
Chain | Residue | Details |
A | GLU445 | |
B | LYS326 | |
D | LYS326 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:Q71U36 |
Chain | Residue | Details |
A | TYR451 | |
C | TYR451 |
site_id | SWS_FT_FI12 |
Number of Residues | 6 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P68363 |
Chain | Residue | Details |
A | LYS326 | |
A | LYS370 | |
C | LYS326 | |
C | LYS370 |