4ZI0

Endonuclease inhibitor bound to influenza strain H1N1 polymerase acidic subunit N-terminal region without a chelation to the metal ions in the active site

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 A 301

Chain	Residue
A	ARG124
A	ARG179
A	TRP188
A	ARG192

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MN A 302

Chain	Residue
A	HOH524
A	HIS41
A	ASP108
A	GLU119
A	ILE120
A	HOH508

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MN A 303

Chain	Residue
A	GLU80
A	ASP108
A	HOH435
A	HOH481
A	HOH524
A	HOH537

---

site_id	AC4
Number of Residues	10
Details	binding site for residue 4P9 A 304

Chain	Residue
A	GLU31
A	LYS34
A	ALA37
A	THR123
A	ARG124
A	PHE150
A	PHE191
A	SER194
A	GLU195
A	HOH411

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	Motif: {"description":"Nuclear localization signal 1 (NLS1)","evidences":[{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8113737","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26252962","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27088785","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YYL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZI0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZQQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27088785","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YYL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZI0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZQQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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