4ZFK
Ergothioneine-biosynthetic Ntn hydrolase EgtC with glutamine
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006541 | biological_process | glutamine metabolic process |
A | 0016787 | molecular_function | hydrolase activity |
A | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
A | 0052699 | biological_process | ergothioneine biosynthetic process |
A | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
B | 0006541 | biological_process | glutamine metabolic process |
B | 0016787 | molecular_function | hydrolase activity |
B | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
B | 0052699 | biological_process | ergothioneine biosynthetic process |
B | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
C | 0006541 | biological_process | glutamine metabolic process |
C | 0016787 | molecular_function | hydrolase activity |
C | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
C | 0052699 | biological_process | ergothioneine biosynthetic process |
C | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
D | 0006541 | biological_process | glutamine metabolic process |
D | 0016787 | molecular_function | hydrolase activity |
D | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
D | 0052699 | biological_process | ergothioneine biosynthetic process |
D | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | binding site for residue EDO A 301 |
Chain | Residue |
A | LEU19 |
A | ASP20 |
A | PRO21 |
A | VAL27 |
A | HOH406 |
A | HOH509 |
site_id | AC2 |
Number of Residues | 8 |
Details | binding site for residue EDO A 302 |
Chain | Residue |
A | ASP211 |
A | HOH448 |
A | HOH452 |
A | HOH492 |
A | HOH521 |
A | GLY181 |
A | ASP182 |
A | THR183 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue EDO A 303 |
Chain | Residue |
A | ARG58 |
A | ARG60 |
A | EDO304 |
A | HOH414 |
A | HOH562 |
B | SER70 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue EDO A 304 |
Chain | Residue |
A | ARG58 |
A | EDO303 |
A | HOH407 |
B | SER73 |
site_id | AC5 |
Number of Residues | 14 |
Details | binding site for residue GLN A 305 |
Chain | Residue |
A | CYS2 |
A | ARG88 |
A | SER89 |
A | ALA90 |
A | THR91 |
A | ASN114 |
A | GLY115 |
A | VAL132 |
A | ASP133 |
A | SER134 |
A | HOH445 |
A | HOH486 |
A | HOH489 |
A | HOH581 |
site_id | AC6 |
Number of Residues | 7 |
Details | binding site for residue EDO B 301 |
Chain | Residue |
B | GLY38 |
B | SER89 |
B | THR91 |
B | GLN311 |
B | HOH464 |
B | HOH472 |
B | HOH493 |
site_id | AC7 |
Number of Residues | 7 |
Details | binding site for residue EDO B 302 |
Chain | Residue |
B | LEU19 |
B | ASP20 |
B | PRO21 |
B | VAL27 |
B | HOH416 |
B | HOH480 |
B | HOH562 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue EDO B 303 |
Chain | Residue |
B | MET40 |
B | HOH409 |
B | HOH439 |
D | TRP66 |
site_id | AC9 |
Number of Residues | 6 |
Details | binding site for residue EDO B 304 |
Chain | Residue |
A | ALA69 |
A | SER70 |
B | ARG58 |
B | ARG60 |
B | HOH402 |
B | HOH506 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue EDO B 305 |
Chain | Residue |
B | TRP66 |
B | GLY67 |
B | ALA72 |
B | HOH444 |
B | HOH575 |
B | HOH619 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue EDO B 306 |
Chain | Residue |
B | PHE50 |
B | ASP51 |
B | ARG81 |
B | GLY172 |
B | HOH504 |
site_id | AD3 |
Number of Residues | 5 |
Details | binding site for residue EDO B 307 |
Chain | Residue |
B | ALA151 |
B | LEU228 |
B | HIS230 |
B | HOH433 |
B | HOH551 |
site_id | AD4 |
Number of Residues | 8 |
Details | binding site for residue EDO B 308 |
Chain | Residue |
B | GLY181 |
B | ASP182 |
B | THR183 |
B | ASP211 |
B | HOH422 |
B | HOH431 |
B | HOH435 |
B | HOH518 |
site_id | AD5 |
Number of Residues | 6 |
Details | binding site for residue EDO B 309 |
Chain | Residue |
B | TRP109 |
B | GLY145 |
B | LEU146 |
B | ASP147 |
B | HOH414 |
B | HOH463 |
site_id | AD6 |
Number of Residues | 5 |
Details | binding site for residue EDO B 310 |
Chain | Residue |
B | ARG34 |
B | TRP206 |
B | SER207 |
B | ASP208 |
B | HOH516 |
site_id | AD7 |
Number of Residues | 13 |
Details | binding site for residue GLN B 311 |
Chain | Residue |
B | SER89 |
B | THR91 |
B | ASN114 |
B | GLY115 |
B | VAL132 |
B | ASP133 |
B | SER134 |
B | EDO301 |
B | HOH451 |
B | HOH492 |
B | HOH493 |
B | CYS2 |
B | ARG88 |
site_id | AD8 |
Number of Residues | 6 |
Details | binding site for residue EDO C 301 |
Chain | Residue |
C | ARG58 |
C | ARG60 |
C | HOH407 |
C | HOH413 |
D | ALA69 |
D | SER70 |
site_id | AD9 |
Number of Residues | 6 |
Details | binding site for residue EDO C 302 |
Chain | Residue |
C | HIS37 |
C | SER89 |
C | THR91 |
C | GLN309 |
C | HOH533 |
C | HOH559 |
site_id | AE1 |
Number of Residues | 5 |
Details | binding site for residue EDO C 303 |
Chain | Residue |
C | LEU8 |
C | VAL217 |
C | ARG218 |
C | ASP219 |
C | ALA220 |
site_id | AE2 |
Number of Residues | 5 |
Details | binding site for residue EDO C 304 |
Chain | Residue |
C | LEU19 |
C | ASP20 |
C | PRO21 |
C | VAL27 |
C | HOH415 |
site_id | AE3 |
Number of Residues | 3 |
Details | binding site for residue EDO C 305 |
Chain | Residue |
C | ARG33 |
C | ARG34 |
C | HOH405 |
site_id | AE4 |
Number of Residues | 4 |
Details | binding site for residue EDO C 306 |
Chain | Residue |
C | ALA56 |
C | ARG58 |
C | SER105 |
C | HOH418 |
site_id | AE5 |
Number of Residues | 4 |
Details | binding site for residue EDO C 307 |
Chain | Residue |
C | ARG144 |
C | GLU155 |
C | LEU159 |
C | HOH409 |
site_id | AE6 |
Number of Residues | 5 |
Details | binding site for residue EDO C 308 |
Chain | Residue |
C | ASP182 |
C | ASP211 |
C | HOH433 |
C | HOH487 |
C | HOH497 |
site_id | AE7 |
Number of Residues | 13 |
Details | binding site for residue GLN C 309 |
Chain | Residue |
C | CYS2 |
C | ARG88 |
C | SER89 |
C | THR91 |
C | ASN114 |
C | GLY115 |
C | VAL132 |
C | ASP133 |
C | SER134 |
C | EDO302 |
C | HOH475 |
C | HOH510 |
C | HOH533 |
site_id | AE8 |
Number of Residues | 3 |
Details | binding site for residue EDO D 301 |
Chain | Residue |
D | LEU19 |
D | VAL27 |
D | HOH421 |
site_id | AE9 |
Number of Residues | 5 |
Details | binding site for residue EDO D 302 |
Chain | Residue |
C | ALA69 |
C | SER70 |
D | ARG58 |
D | ARG60 |
D | HOH404 |
site_id | AF1 |
Number of Residues | 4 |
Details | binding site for residue EDO D 303 |
Chain | Residue |
D | VAL117 |
D | ASP118 |
D | ARG119 |
D | HOH475 |
site_id | AF2 |
Number of Residues | 6 |
Details | binding site for residue EDO D 304 |
Chain | Residue |
D | TRP109 |
D | GLY145 |
D | LEU146 |
D | ASP147 |
D | HOH411 |
D | HOH483 |
site_id | AF3 |
Number of Residues | 5 |
Details | binding site for residue EDO D 305 |
Chain | Residue |
C | ALA77 |
D | ALA77 |
D | LEU78 |
D | ARG79 |
D | HOH423 |
site_id | AF4 |
Number of Residues | 12 |
Details | binding site for residue GLN D 306 |
Chain | Residue |
D | CYS2 |
D | ARG88 |
D | SER89 |
D | THR91 |
D | ASN114 |
D | GLY115 |
D | VAL132 |
D | ASP133 |
D | SER134 |
D | HOH453 |
D | HOH479 |
D | HOH513 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU00609 |
Chain | Residue | Details |
A | CYS2 | |
B | CYS2 | |
C | CYS2 | |
D | CYS2 |