4ZFK
Ergothioneine-biosynthetic Ntn hydrolase EgtC with glutamine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| A | 0052699 | biological_process | ergothioneine biosynthetic process |
| A | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| B | 0052699 | biological_process | ergothioneine biosynthetic process |
| B | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| C | 0052699 | biological_process | ergothioneine biosynthetic process |
| C | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| D | 0052699 | biological_process | ergothioneine biosynthetic process |
| D | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 301 |
| Chain | Residue |
| A | LEU19 |
| A | ASP20 |
| A | PRO21 |
| A | VAL27 |
| A | HOH406 |
| A | HOH509 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 302 |
| Chain | Residue |
| A | ASP211 |
| A | HOH448 |
| A | HOH452 |
| A | HOH492 |
| A | HOH521 |
| A | GLY181 |
| A | ASP182 |
| A | THR183 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 303 |
| Chain | Residue |
| A | ARG58 |
| A | ARG60 |
| A | EDO304 |
| A | HOH414 |
| A | HOH562 |
| B | SER70 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 304 |
| Chain | Residue |
| A | ARG58 |
| A | EDO303 |
| A | HOH407 |
| B | SER73 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | binding site for residue GLN A 305 |
| Chain | Residue |
| A | CYS2 |
| A | ARG88 |
| A | SER89 |
| A | ALA90 |
| A | THR91 |
| A | ASN114 |
| A | GLY115 |
| A | VAL132 |
| A | ASP133 |
| A | SER134 |
| A | HOH445 |
| A | HOH486 |
| A | HOH489 |
| A | HOH581 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 301 |
| Chain | Residue |
| B | GLY38 |
| B | SER89 |
| B | THR91 |
| B | GLN311 |
| B | HOH464 |
| B | HOH472 |
| B | HOH493 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 302 |
| Chain | Residue |
| B | LEU19 |
| B | ASP20 |
| B | PRO21 |
| B | VAL27 |
| B | HOH416 |
| B | HOH480 |
| B | HOH562 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 303 |
| Chain | Residue |
| B | MET40 |
| B | HOH409 |
| B | HOH439 |
| D | TRP66 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 304 |
| Chain | Residue |
| A | ALA69 |
| A | SER70 |
| B | ARG58 |
| B | ARG60 |
| B | HOH402 |
| B | HOH506 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 305 |
| Chain | Residue |
| B | TRP66 |
| B | GLY67 |
| B | ALA72 |
| B | HOH444 |
| B | HOH575 |
| B | HOH619 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 306 |
| Chain | Residue |
| B | PHE50 |
| B | ASP51 |
| B | ARG81 |
| B | GLY172 |
| B | HOH504 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 307 |
| Chain | Residue |
| B | ALA151 |
| B | LEU228 |
| B | HIS230 |
| B | HOH433 |
| B | HOH551 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 308 |
| Chain | Residue |
| B | GLY181 |
| B | ASP182 |
| B | THR183 |
| B | ASP211 |
| B | HOH422 |
| B | HOH431 |
| B | HOH435 |
| B | HOH518 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 309 |
| Chain | Residue |
| B | TRP109 |
| B | GLY145 |
| B | LEU146 |
| B | ASP147 |
| B | HOH414 |
| B | HOH463 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 310 |
| Chain | Residue |
| B | ARG34 |
| B | TRP206 |
| B | SER207 |
| B | ASP208 |
| B | HOH516 |
| site_id | AD7 |
| Number of Residues | 13 |
| Details | binding site for residue GLN B 311 |
| Chain | Residue |
| B | SER89 |
| B | THR91 |
| B | ASN114 |
| B | GLY115 |
| B | VAL132 |
| B | ASP133 |
| B | SER134 |
| B | EDO301 |
| B | HOH451 |
| B | HOH492 |
| B | HOH493 |
| B | CYS2 |
| B | ARG88 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 301 |
| Chain | Residue |
| C | ARG58 |
| C | ARG60 |
| C | HOH407 |
| C | HOH413 |
| D | ALA69 |
| D | SER70 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 302 |
| Chain | Residue |
| C | HIS37 |
| C | SER89 |
| C | THR91 |
| C | GLN309 |
| C | HOH533 |
| C | HOH559 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 303 |
| Chain | Residue |
| C | LEU8 |
| C | VAL217 |
| C | ARG218 |
| C | ASP219 |
| C | ALA220 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 304 |
| Chain | Residue |
| C | LEU19 |
| C | ASP20 |
| C | PRO21 |
| C | VAL27 |
| C | HOH415 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 305 |
| Chain | Residue |
| C | ARG33 |
| C | ARG34 |
| C | HOH405 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 306 |
| Chain | Residue |
| C | ALA56 |
| C | ARG58 |
| C | SER105 |
| C | HOH418 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 307 |
| Chain | Residue |
| C | ARG144 |
| C | GLU155 |
| C | LEU159 |
| C | HOH409 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 308 |
| Chain | Residue |
| C | ASP182 |
| C | ASP211 |
| C | HOH433 |
| C | HOH487 |
| C | HOH497 |
| site_id | AE7 |
| Number of Residues | 13 |
| Details | binding site for residue GLN C 309 |
| Chain | Residue |
| C | CYS2 |
| C | ARG88 |
| C | SER89 |
| C | THR91 |
| C | ASN114 |
| C | GLY115 |
| C | VAL132 |
| C | ASP133 |
| C | SER134 |
| C | EDO302 |
| C | HOH475 |
| C | HOH510 |
| C | HOH533 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 301 |
| Chain | Residue |
| D | LEU19 |
| D | VAL27 |
| D | HOH421 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 302 |
| Chain | Residue |
| C | ALA69 |
| C | SER70 |
| D | ARG58 |
| D | ARG60 |
| D | HOH404 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 303 |
| Chain | Residue |
| D | VAL117 |
| D | ASP118 |
| D | ARG119 |
| D | HOH475 |
| site_id | AF2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 304 |
| Chain | Residue |
| D | TRP109 |
| D | GLY145 |
| D | LEU146 |
| D | ASP147 |
| D | HOH411 |
| D | HOH483 |
| site_id | AF3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 305 |
| Chain | Residue |
| C | ALA77 |
| D | ALA77 |
| D | LEU78 |
| D | ARG79 |
| D | HOH423 |
| site_id | AF4 |
| Number of Residues | 12 |
| Details | binding site for residue GLN D 306 |
| Chain | Residue |
| D | CYS2 |
| D | ARG88 |
| D | SER89 |
| D | THR91 |
| D | ASN114 |
| D | GLY115 |
| D | VAL132 |
| D | ASP133 |
| D | SER134 |
| D | HOH453 |
| D | HOH479 |
| D | HOH513 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 900 |
| Details | Domain: {"description":"Glutamine amidotransferase type-2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00609","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU00609","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
