4ZFJ
Ergothioneine-biosynthetic Ntn hydrolase EgtC, apo form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| A | 0052699 | biological_process | ergothioneine biosynthetic process |
| A | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| B | 0052699 | biological_process | ergothioneine biosynthetic process |
| B | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| C | 0052699 | biological_process | ergothioneine biosynthetic process |
| C | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| D | 0052699 | biological_process | ergothioneine biosynthetic process |
| D | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| E | 0052699 | biological_process | ergothioneine biosynthetic process |
| E | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| F | 0052699 | biological_process | ergothioneine biosynthetic process |
| F | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| G | 0052699 | biological_process | ergothioneine biosynthetic process |
| G | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| H | 0052699 | biological_process | ergothioneine biosynthetic process |
| H | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
| I | 0016787 | molecular_function | hydrolase activity |
| I | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| I | 0052699 | biological_process | ergothioneine biosynthetic process |
| I | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
| J | 0016787 | molecular_function | hydrolase activity |
| J | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| J | 0052699 | biological_process | ergothioneine biosynthetic process |
| J | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
| K | 0016787 | molecular_function | hydrolase activity |
| K | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| K | 0052699 | biological_process | ergothioneine biosynthetic process |
| K | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
| L | 0016787 | molecular_function | hydrolase activity |
| L | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| L | 0052699 | biological_process | ergothioneine biosynthetic process |
| L | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue MES A 301 |
| Chain | Residue |
| A | LEU39 |
| A | MSE40 |
| A | SER89 |
| A | HOH505 |
| A | HOH547 |
| A | HOH577 |
| C | TYR30 |
| C | TRP66 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue MES A 302 |
| Chain | Residue |
| C | MSE40 |
| C | SER89 |
| A | TYR30 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue MES B 301 |
| Chain | Residue |
| B | LEU39 |
| B | MSE40 |
| B | SER89 |
| B | HOH407 |
| B | HOH492 |
| B | HOH566 |
| D | TYR30 |
| D | TRP66 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue XPE B 302 |
| Chain | Residue |
| A | MSE94 |
| A | SER95 |
| A | HOH475 |
| A | HOH548 |
| B | ALA56 |
| B | ARG58 |
| B | ARG60 |
| B | SER105 |
| B | GLY107 |
| B | HOH482 |
| C | ALA69 |
| C | SER70 |
| C | SER73 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | binding site for residue XPE C 301 |
| Chain | Residue |
| B | TRP66 |
| B | GLY67 |
| B | ALA69 |
| B | SER70 |
| C | ALA56 |
| C | ARG58 |
| C | ARG60 |
| C | SER99 |
| C | HOH466 |
| C | HOH554 |
| D | GLY93 |
| D | MSE94 |
| D | SER95 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue MES D 301 |
| Chain | Residue |
| B | TYR30 |
| B | TRP66 |
| D | LEU39 |
| D | MSE40 |
| D | SER89 |
| D | ILE92 |
| D | HOH469 |
| D | HOH538 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | binding site for residue XPE D 302 |
| Chain | Residue |
| A | ALA56 |
| A | ARG58 |
| A | ARG60 |
| A | PRO98 |
| A | HOH512 |
| B | GLY93 |
| B | MSE94 |
| B | SER95 |
| B | HOH526 |
| D | TRP66 |
| D | GLY67 |
| D | ALA69 |
| D | SER70 |
| D | HOH495 |
| D | HOH505 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | binding site for residue XPE D 303 |
| Chain | Residue |
| A | TRP66 |
| A | GLY67 |
| A | ALA69 |
| A | SER70 |
| A | ALA72 |
| A | HOH473 |
| C | MSE94 |
| D | ALA56 |
| D | ARG58 |
| D | ARG60 |
| D | HOH501 |
| D | HOH549 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue MES E 301 |
| Chain | Residue |
| E | LEU39 |
| E | MSE40 |
| E | SER89 |
| E | HOH445 |
| K | TYR30 |
| K | TRP66 |
| site_id | AD1 |
| Number of Residues | 17 |
| Details | binding site for residue XPE E 302 |
| Chain | Residue |
| J | SER70 |
| J | SER73 |
| J | HOH414 |
| J | HOH474 |
| E | ALA56 |
| E | ARG58 |
| E | ARG60 |
| E | PRO98 |
| E | HOH414 |
| H | GLY93 |
| H | MSE94 |
| H | SER95 |
| H | HOH430 |
| H | HOH556 |
| J | TRP66 |
| J | GLY67 |
| J | ALA69 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue MES F 301 |
| Chain | Residue |
| F | MSE40 |
| F | SER89 |
| L | TYR30 |
| L | TRP66 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue MES G 301 |
| Chain | Residue |
| G | MSE40 |
| G | SER89 |
| G | HOH404 |
| I | TYR30 |
| I | TRP66 |
| site_id | AD4 |
| Number of Residues | 13 |
| Details | binding site for residue XPE G 302 |
| Chain | Residue |
| F | GLY93 |
| F | MSE94 |
| F | SER95 |
| G | ALA56 |
| G | ARG58 |
| G | ARG60 |
| G | SER105 |
| G | HOH531 |
| L | GLY67 |
| L | ALA69 |
| L | SER70 |
| L | SER73 |
| L | HOH438 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue MES H 301 |
| Chain | Residue |
| H | LEU39 |
| H | MSE40 |
| H | SER89 |
| H | HOH479 |
| J | TRP66 |
| site_id | AD6 |
| Number of Residues | 13 |
| Details | binding site for residue XPE H 302 |
| Chain | Residue |
| E | MSE94 |
| E | HOH504 |
| H | ALA56 |
| H | ARG58 |
| H | ARG60 |
| H | SER105 |
| H | HOH581 |
| K | GLY67 |
| K | ALA69 |
| K | SER70 |
| K | SER73 |
| K | HOH430 |
| K | HOH489 |
| site_id | AD7 |
| Number of Residues | 9 |
| Details | binding site for residue MES I 301 |
| Chain | Residue |
| G | TYR30 |
| G | TRP66 |
| I | GLY38 |
| I | LEU39 |
| I | MSE40 |
| I | SER89 |
| I | ILE92 |
| I | HOH524 |
| I | HOH550 |
| site_id | AD8 |
| Number of Residues | 13 |
| Details | binding site for residue XPE I 302 |
| Chain | Residue |
| F | TRP66 |
| F | GLY67 |
| F | ALA69 |
| F | SER70 |
| F | ALA72 |
| I | ALA56 |
| I | ARG58 |
| I | ARG60 |
| I | PRO98 |
| I | HOH441 |
| I | HOH595 |
| L | MSE94 |
| L | HOH505 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue MES J 301 |
| Chain | Residue |
| H | TRP66 |
| J | LEU39 |
| J | MSE40 |
| J | SER89 |
| J | HOH513 |
| site_id | AE1 |
| Number of Residues | 10 |
| Details | binding site for residue XPE J 302 |
| Chain | Residue |
| E | TRP66 |
| E | GLY67 |
| E | ALA69 |
| E | SER70 |
| E | SER73 |
| E | HOH428 |
| J | ARG58 |
| J | ARG60 |
| J | HOH551 |
| K | MSE94 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue MES K 301 |
| Chain | Residue |
| E | TYR30 |
| E | TRP66 |
| K | LEU39 |
| K | MSE40 |
| K | SER89 |
| K | HOH425 |
| site_id | AE3 |
| Number of Residues | 13 |
| Details | binding site for residue XPE K 302 |
| Chain | Residue |
| H | TRP66 |
| H | GLY67 |
| H | ALA69 |
| H | SER70 |
| H | ALA72 |
| H | HOH437 |
| J | MSE94 |
| K | ARG58 |
| K | ARG60 |
| K | PRO98 |
| K | HOH508 |
| K | HOH529 |
| K | HOH540 |
| site_id | AE4 |
| Number of Residues | 8 |
| Details | binding site for residue MES L 301 |
| Chain | Residue |
| F | TYR30 |
| F | TRP66 |
| L | LEU39 |
| L | MSE40 |
| L | SER89 |
| L | HOH468 |
| L | HOH485 |
| L | HOH525 |
| site_id | AE5 |
| Number of Residues | 12 |
| Details | binding site for residue XPE L 302 |
| Chain | Residue |
| G | TRP66 |
| G | GLY67 |
| G | ALA69 |
| G | SER70 |
| I | MSE94 |
| I | SER95 |
| L | ALA56 |
| L | ARG58 |
| L | ARG60 |
| L | SER105 |
| L | HOH473 |
| L | HOH475 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU00609","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
