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4ZF7

Crystal structure of ferret interleukin-2

Functional Information from GO Data
ChainGOidnamespacecontents
A0002250biological_processadaptive immune response
A0002366biological_processleukocyte activation involved in immune response
A0002639biological_processpositive regulation of immunoglobulin production
A0002903biological_processnegative regulation of B cell apoptotic process
A0005125molecular_functioncytokine activity
A0005134molecular_functioninterleukin-2 receptor binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006366biological_processtranscription by RNA polymerase II
A0006955biological_processimmune response
A0008083molecular_functiongrowth factor activity
A0010467biological_processgene expression
A0030890biological_processpositive regulation of B cell proliferation
A0032729biological_processpositive regulation of type II interferon production
A0032740biological_processpositive regulation of interleukin-17 production
A0038110biological_processinterleukin-2-mediated signaling pathway
A0042098biological_processT cell proliferation
A0042102biological_processpositive regulation of T cell proliferation
A0042104biological_processpositive regulation of activated T cell proliferation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046013biological_processregulation of T cell homeostatic proliferation
A0046651biological_processlymphocyte proliferation
A0048304biological_processpositive regulation of isotype switching to IgG isotypes
A0050672biological_processnegative regulation of lymphocyte proliferation
A0050728biological_processnegative regulation of inflammatory response
A0050798biological_processactivated T cell proliferation
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0097696biological_processcell surface receptor signaling pathway via STAT
A1900100biological_processpositive regulation of plasma cell differentiation
A2000320biological_processnegative regulation of T-helper 17 cell differentiation
A2000561biological_processregulation of CD4-positive, alpha-beta T cell proliferation
B0002250biological_processadaptive immune response
B0002366biological_processleukocyte activation involved in immune response
B0002639biological_processpositive regulation of immunoglobulin production
B0002903biological_processnegative regulation of B cell apoptotic process
B0005125molecular_functioncytokine activity
B0005134molecular_functioninterleukin-2 receptor binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006366biological_processtranscription by RNA polymerase II
B0006955biological_processimmune response
B0008083molecular_functiongrowth factor activity
B0010467biological_processgene expression
B0030890biological_processpositive regulation of B cell proliferation
B0032729biological_processpositive regulation of type II interferon production
B0032740biological_processpositive regulation of interleukin-17 production
B0038110biological_processinterleukin-2-mediated signaling pathway
B0042098biological_processT cell proliferation
B0042102biological_processpositive regulation of T cell proliferation
B0042104biological_processpositive regulation of activated T cell proliferation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046013biological_processregulation of T cell homeostatic proliferation
B0046651biological_processlymphocyte proliferation
B0048304biological_processpositive regulation of isotype switching to IgG isotypes
B0050672biological_processnegative regulation of lymphocyte proliferation
B0050728biological_processnegative regulation of inflammatory response
B0050798biological_processactivated T cell proliferation
B0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
B0097696biological_processcell surface receptor signaling pathway via STAT
B1900100biological_processpositive regulation of plasma cell differentiation
B2000320biological_processnegative regulation of T-helper 17 cell differentiation
B2000561biological_processregulation of CD4-positive, alpha-beta T cell proliferation
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue SO4 A 201
ChainResidue
AGLY97
ASER98
APEG204
AHOH302
AHOH325
BLYS30

site_idAC2
Number of Residues6
Detailsbinding site for residue PG4 A 202
ChainResidue
AVAL111
ALYS119
AHOH301
AASP107
AGLU109
ATHR110

site_idAC3
Number of Residues10
Detailsbinding site for residue PG4 A 203
ChainResidue
AGLU65
AGLU66
ATYR69
ALYS82
AMET85
ASER86
AASN89
AHOH316
AHOH339
AHOH384

site_idAC4
Number of Residues8
Detailsbinding site for residue PEG A 204
ChainResidue
ALEU95
ALYS96
AGLY97
ASER98
ASO4201
BLYS30
BTYR32
BTHR114

site_idAC5
Number of Residues7
Detailsbinding site for residue SO4 B 201
ChainResidue
ALYS94
AHOH377
BPRO35
BARG36
BHOH308
BHOH320
BHOH333

site_idAC6
Number of Residues6
Detailsbinding site for residue 1PE B 202
ChainResidue
BGLU65
BLYS82
BMET85
BSER86
BHOH312
BHOH317

Functional Information from PROSITE/UniProt
site_idPS00424
Number of Residues13
DetailsINTERLEUKIN_2 Interleukin-2 signature. TELthLqCLaeEL
ChainResidueDetails
ATHR49-LEU61

223790

PDB entries from 2024-08-14

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